Inclusion Complexes of Lycopene and β-Cyclodextrin: Preparation, Characterization, Stability and Antioxidant Activity

Antioxidants - Tập 8 Số 8 - Trang 314
Haixiang Wang1,2, Shaofeng Wang2, Hua Zhu2, Suilou Wang2, Jiudong Xing3,4
1Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University (BTBU), Haidian District, Beijing 100048, China.
2Department of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, China.
3Department of Food Quality and Safety, School of Engineering, China Pharmaceutical University, Jiangning District, Nanjing 211198, China. [email protected].
4Pharmaceutical Experimental Training Center, School of Pharmacy, China Pharmaceutical University, Jiangning District, Nanjing 211198, China. [email protected].

Tóm tắt

In this study, the inclusion complexes of lycopene with β-cyclodextrin (β-CD) were prepared by the precipitation method. Then the inclusion complexes were characterized by the scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV), microscopic observation, liquid chromatography, differential scanning calorimetry (DSC) and phase-solubility study. Moreover, the stability and antioxidant activity were tested. The results showed that lycopene was embedded into the cavity of β-CD with a 1:1 stoichiometry. Moreover, the thermal and irradiant stabilities of lycopene were all significantly increased by the formation of lycopene/β-CD inclusion complexes. Antioxidant properties of lycopene and its inclusion complexes were evaluated on the basis of measuring the scavenging activity for 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydroxyl and superoxide anion radicals. The results showed that the scavenging activity of DPPH radicals was obviously increased by the formation of the inclusion complex with β-cyclodextrin at concentrations of 5–30 μg/mL, however, some significant positive effects on the scavenging activity of hydroxyl and superoxide anion radicals were not observed and the reasons are worth further study.

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