Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment

Deutsche Zeitschrift für Nervenheilkunde - Tập 255 - Trang 828-830 - 2008
M. C. J. Hanse1, M. B. van’t Veer2, K. van Lom2, M. J. van den Bent1
1Dept. of Neuro-Oncology, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
2Dept. of Hematology, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

Tóm tắt

Leptomeningeal involvement in patients with CLL is relatively rare and the prognosis is usually considered to be poor. The authors reviewed all CLL patients treated in a tertiary referral center to assess the incidence and outcome of leptomeningeal involvement (LI) in CLL. They found an incidence of 1–2% of LI. Most of the patients with LI had a longterm survival, despite failure to clear the cerebrospinal fluid from tumor cells.

Tài liệu tham khảo

Barcos M, Lane W, Gomez GA, et al. (1987) An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer 60:827–837 Knop S, Herrlinger U, Ernemann U, et al. (2005) Fludarabine may induce durable remission in patients with leptomeningeal involvement of chronic lymphocytic leukemia. Leuk Lymphoma 46:1593–1598 Paolini R, Ramazzina E, Zennaro R, et al. (1995) Remission of leukemic meningitis after fludarabine. Lancet 346:972 Elliott MA, Letendre L, Li CY, Hoyer JD, Hammack JE (1999) Chronic lymphocytic leukaemia with symptomatic diffuse central nervous system infiltration responding to therapy with systemic fludarabine. Br J Haematol 104:689–694 Cramer SC, Glaspy JA, Efird JT, Louis DN (1996) Chronic lymphocytic leukemia and the central nervous system: A clinical and pathological study. Neurology 46:19–25 Montillo M, Hamblin T, Hallek M, Montserrat E, Morra E (2005) Chronic lymphocytic leukaemia: novel prognostic factors and their relevance for riskadapted therapeutic strategies. Haematologica 90:391–399 Weizsaecker M, Koelmer HW (1979) Meningeal involvement in leukemias and malignant lymphomas of adults: Incidence, course of disease and treatment for prevention. Acta Neurol Scand 60:363–370