Incidence of Amyotrophic Lateral Sclerosis and of the Parkinsonism-Dementia Complex of Guam, 1950–1989

Neuroepidemiology - Tập 23 Số 4 - Trang 192-200 - 2004
Stephen C. Waring1, Cony Esteban-Santillan2, Dwayne Reed3, Ulla-Katrina Craig4, Darwin R. Labarthe5, Ronald C. Petersen6, Leonard T. Kurland7
1Epidemiology Discipline, University of Texas School of Public Health, Houston, Tex.,
2Department of Neurology, Case Western Reserve University, Cleveland, Ohio
3Sonoma, Calif.,
4School of Nursing and Allied Health Sciences, University of Guam, Mangilao, Guam,
5Center for Disease Control and Prevention, Atlanta, GA
6Department of Neurology
7Emeritus Staff, Mayo Clinic and Foundation, Rochester, Minn., USA

Tóm tắt

Studies representing the accumulated information from the first 30 years of research effort on Guam (1950–1979) have demonstrated a varying degree of decline in the incidence of amyotrophic lateral sclerosis (ALS) and the parkinsonism-dementia complex (PDC) of Guam. Analysis with more complete information for the period 1980–1989 provides more valid estimates of the later patterns in the incidence of ALS and PDC and affords a more extensive assessment of trends over a 40-year period. The annual age-adjusted incidence of ALS was 7/100,000 and the annual age-adjusted incidence of PDC was 22/100,000 in 1989. The incidence was much higher for the period 1980–1989 than suggested in previous reports. These findings provide compelling evidence that this spectrum of neurodegenerative diseases continues to have a significant impact on the health of the Chamorro people of Guam.

Từ khóa


Tài liệu tham khảo

10.1093/aje/kwf175

10.1016/S0022-510X(01)00630-X

Thông tin
Thông tin xuất bản

Neuroepidemiology

Tập 23 Số 4

192-200

Thông tin tác giả