Incidence and lifetime risk of motor neuron disease in the United Kingdom: a population‐based study

European Journal of Neurology - Tập 16 Số 6 - Trang 745-751 - 2009
Álvaro Alonso1, Giancarlo Logroscino2, Susan S. Jick3, Miguel A. Hernán4
1Division of Epidemiology and Community Health, University of Minnesota, 1300 S. 2nd St., Suite 300, Minneapolis, MN, 55454, USA.
2Department of Neurological Sciences, University of Bari, Bari, Italy
3Boston Collaborative Drug Surveillance Program, Boston University, Lexington, MA
4Department of Epidemiology, Harvard School of Public Health, and Harvard‐MIT Division of Health Sciences and Technology, Boston, MA, USA

Tóm tắt

Background and purpose:  To estimate the incidence and lifetime risk of motor neuron disease (MND) in a population‐based sample in the United Kingdom.Methods:  We identified new cases of MND during the period 1990–2005 in the General Practice Research Database, which includes clinical information from more than 3 million Britons enrolled with selected general practitioners. Individuals with a first medical diagnosis of MND recorded in the database were considered incident cases of the disease. The positive predictive value of the computer‐based diagnosis was estimated through review of a sample of medical records from potential MND cases.Results:  In the period 1990–2005, 830 new cases of MND were identified. Age‐standardized incidence of MND was 2.6 per 100 000 persons per year in women (95% CI: 2.3, 2.8) and 3.9 in men (95% CI: 3.6, 4.3). Incidence for both sexes peaked between 75 and 79 years. The rate of MND in men was 54% higher than in women (95% CI: 33%, 77%). The lifetime risk of MND, adjusting for competing causes of death, was 1 in 472 (2.1 per 1000) in women and 1 in 350 (2.9 per 1000) in men. No increase in MND incidence over time was apparent.Conclusion:  In this population‐based database, we found that MND incidence is higher in men than women, peaking in both sexes between 75 and 79 years.

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Thông tin
Thông tin xuất bản

European Journal of Neurology

Tập 16 Số 6

745-751

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