In-vivo transfection of the proopiomelanocortin gene, precursor of endogenous endorphin, by use of radial shock waves alleviates neuropathic pain

Tetsuhiro Ishikawa, Masayuki Miyagi1, Masaomi Yamashita1, Hiroto Kamoda1, Yawara Eguchi1, Gen Arai1, Miyako Suzuki1, Yoshihiro Sakuma1, Yasuhiro Oikawa1, Sumihisa Orita1, Gen Inoue1, Tomoyuki Ozawa2, Yasuchika Aoki3, Tomoaki Toyone4, Kazuhisa Takahashi4, Atsushi Yamaguchi5, Seiji Ohtori6
1Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
2Department of Orthopaedic Surgery, Social Insurance Funabashi Central Hospital, Funabashi, Japan
3Department of Orthopaedic Surgery, Matsudo City Hospital, Matsudo, Japan
4Department of Orthopaedic Surgery, Teikyo University Chiba Medical Center, Chiba, Japan
5Department of Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan
6Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan

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