Khám phá sự phụ thuộc vào môi trường vi mô trong ung thư bạch cầu cấp tính ở chuột thông qua sàng lọc CRISPR toàn bộ bộ gen tại chỗ

Papaemmanuil, 2016, Genomic classification and prognosis in acute myeloid leukemia, N Engl J Med., 374, 2209, 10.1056/NEJMoa1516192 Tyner, 2018, Functional genomic landscape of acute myeloid leukaemia, Nature., 562, 526, 10.1038/s41586-018-0623-z Ley, 2013, Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia, N Engl J Med., 368, 2059, 10.1056/NEJMoa1301689 Shih, 2015, Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia, Cancer Cell., 27, 502, 10.1016/j.ccell.2015.03.009 Perl, 2019, Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML, N Engl J Med., 381, 1728, 10.1056/NEJMoa1902688 Stone, 2017, Midostaurin plus chemotherapy for acute myeloid leukemia with a FLT3 mutation, N Engl J Med., 377, 454, 10.1056/NEJMoa1614359 Borella, 2021, Targeting the plasticity of mesenchymal stromal cells to reroute the course of acute myeloid leukemia, Blood., 138, 557 Barbier, 2020, Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance, Nat Commun., 11, 2042, 10.1038/s41467-020-15817-5 Kokkaliaris, 2020, Cell interactions in the bone marrow microenvironment affecting myeloid malignancies, Blood Adv., 4, 3795, 10.1182/bloodadvances.2020002127 van Gastel, 2020, Induction of a timed metabolic collapse to overcome cancer chemoresistance, Cell Metab., 32, 391, 10.1016/j.cmet.2020.07.009 Forte, 2020, Bone marrow mesenchymal stem cells support acute myeloid leukemia bioenergetics and enhance antioxidant defense and escape from chemotherapy, Cell Metab., 32, 829, 10.1016/j.cmet.2020.09.001 Ye, 2016, Leukemic stem cells evade chemotherapy by metabolic adaptation to an adipose tissue niche, Cell Stem Cell., 19, 23, 10.1016/j.stem.2016.06.001 Majeti, 2009, CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells, Cell., 138, 286, 10.1016/j.cell.2009.05.045 Herbrich, 2021, Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML, J Immunother Cancer., 9, 1, 10.1136/jitc-2021-002968 Xu, 2021, Regulatory T cells promote the stemness of leukemia stem cells through IL10 cytokine-related signaling pathway, Leukemia., 36, 403, 10.1038/s41375-021-01375-2 Ramdas, 2020, Driver mutations in leukemia promote disease pathogenesis through a combination of cell-autonomous and niche modulation, Stem Cell Reports., 15, 95, 10.1016/j.stemcr.2020.05.002 Duarte, 2018, Inhibition of endosteal vascular niche remodeling rescues hematopoietic stem cell loss in AML, Cell Stem Cell., 22, 64, 10.1016/j.stem.2017.11.006 Basheer, 2019, Genome-scale drop-out screens to identify cancer cell vulnerabilities in AML, Curr Opin Genet Dev., 54, 83, 10.1016/j.gde.2019.04.004 Barbieri, 2017, Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control, Nature., 552, 126, 10.1038/nature24678 Yamauchi, 2018, Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by DCPS, Cancer Cell., 33, 386, 10.1016/j.ccell.2018.01.012 Cao, 2021, ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency, Mol Cell., 81, 3604, 10.1016/j.molcel.2021.07.018 Zhang, 2020, Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen, eLife., 9, 1, 10.7554/eLife.57858 Seneviratne, 2019, The mitochondrial transacylase, tafazzin, regulates for AML stemness by modulating intracellular levels of phospholipids, Cell Stem Cell., 24, 621, 10.1016/j.stem.2019.02.020 Khan, 2020, Mitochondrial carrier homolog 2 is necessary for AML survival, Blood., 136, 81, 10.1182/blood.2019000106 Chen, 2020, Vitamin B6 addiction in acute myeloid leukemia, Cancer Cell., 37, 71, 10.1016/j.ccell.2019.12.002 Dai, 2021, In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy, Nat Commun., 12, 3055, 10.1038/s41467-021-23316-4 Ramakrishnan, 2020, CXCR4 signaling has a CXCL12-independent essential role in murine MLL-AF9-driven acute myeloid leukemia, Cell Rep., 31, 107684, 10.1016/j.celrep.2020.107684 Lin, 2022, An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML, Cancer Discov, 12, 432, 10.1158/2159-8290.CD-20-1851 Platt, 2014, CRISPR-Cas9 knockin mice for genome editing and cancer modeling, Cell., 159, 440, 10.1016/j.cell.2014.09.014 Krivtsov, 2006, Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9, Nature., 442, 818, 10.1038/nature04980 Kroon, 1998, Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b, EMBO J., 17, 3714, 10.1093/emboj/17.13.3714 Naviaux, 1996, The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses, J Virol., 70, 5701, 10.1128/jvi.70.8.5701-5705.1996 Sykes, 2016, Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia, Cell., 167, 171, 10.1016/j.cell.2016.08.057 Sanjana, 2014, Improved vectors and genome-wide libraries for CRISPR screening, Nat Methods., 11, 783, 10.1038/nmeth.3047 Griffith, 2013, DGIdb: mining the druggable genome, Nat Methods., 10, 1209, 10.1038/nmeth.2689 Tzelepis, 2016, A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia, Cell Rep., 17, 1193, 10.1016/j.celrep.2016.09.079 Li, 2014, MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens, Genome Biol., 15, 554, 10.1186/s13059-014-0554-4 Margolin, 2006, ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context, BMC Bioinformatics., 7, S7, 10.1186/1471-2105-7-S1-S7 Alvarez, 2016, Functional characterization of somatic mutations in cancer using network-based inference of protein activity, Nat Genet., 48, 838, 10.1038/ng.3593 Ng, 2016, A 17-gene stemness score for rapid determination of risk in acute leukaemia, Nature., 540, 433, 10.1038/nature20598 Bolouri, 2018, The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions, Nat Med., 24, 103, 10.1038/nm.4439 Muntean, 2012, The pathogenesis of mixed-lineage leukemia, Annu Rev Pathol., 7, 283, 10.1146/annurev-pathol-011811-132434 Golub, 1999, Molecular classification of cancer: class discovery and class prediction by gene expression monitoring, 286, 531 Collins, 2016, Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets, Oncogene., 35, 1090, 10.1038/onc.2015.174 Miller, 2013, In vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling, Cancer Cell., 24, 45, 10.1016/j.ccr.2013.05.004 Wang, 2017, Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras, Cell., 168, 890, 10.1016/j.cell.2017.01.013 Bernt, 2011, MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L, Cancer Cell., 20, 66, 10.1016/j.ccr.2011.06.010 Chen, 2006, The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression, Proc Natl Acad Sci USA., 103, 1018, 10.1073/pnas.0510347103 Pillinger, 2016, Targeting PI3Kδ and PI3Kγ signalling disrupts human AML survival and bone marrow stromal cell mediated protection, Oncotarget., 7, 39784, 10.18632/oncotarget.9289 Miwa, 2009, Complement-dependent T-cell lymphopenia caused by thymocyte deletion of the membrane complement regulator Crry, Blood., 113, 2684, 10.1182/blood-2008-05-157966 Giannini, 2020, β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis, Nat Commun., 11, 356, 10.1038/s41467-019-14178-y Jan, 2012, Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia, Sci Transl Med., 4, 149ra118, 10.1126/scitranslmed.3004315 Corces-Zimmerman, 2014, Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission, Proc Natl Acad Sci USA., 111, 2548, 10.1073/pnas.1324297111 Bowman, 2018, Clonal hematopoiesis and evolution to hematopoietic malignancies, Cell Stem Cell., 22, 157, 10.1016/j.stem.2018.01.011 Eriksson, 2015, Epigenetic aberrations in acute myeloid leukemia: early key events during leukemogenesis, Exp Hematol., 43, 609, 10.1016/j.exphem.2015.05.009 Krönke, 2013, Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia, Blood., 122, 100, 10.1182/blood-2013-01-479188 Miwa, 2002, Crry, but not CD59 and DAF, is indispensable for murine erythrocyte protection in vivo from spontaneous complement attack, Blood., 99, 3707, 10.1182/blood.V99.10.3707 Laverdière, 2016, Complement cascade gene expression defines novel prognostic subgroups of acute myeloid leukemia, Exp Hematol., 44, 1039, 10.1016/j.exphem.2016.07.012 Sugahara, 2012, Large-scale identification of target proteins of a glycosyltransferase isozyme by lectin-IGOT-LC/MS, an LC/MS-based glycoproteomic approach, Sci Rep., 2, 680, 10.1038/srep00680 Asano, 2003, Impaired selectin-ligand biosynthesis and reduced inflammatory responses in β-1,4-galactosyltransferase-I- deficient mice, Blood., 102, 1678, 10.1182/blood-2003-03-0836 Pang, 2018, Multiple roles of glycans in hematological malignancies, Front Oncol., 8, 364, 10.3389/fonc.2018.00364 Wilkinson, 2013, RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction, Cell Rep., 3, 116, 10.1016/j.celrep.2012.12.016 Docking, 2021, A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia, Nat Commun., 12, 2474, 10.1038/s41467-021-22625-y Bromberger, 2018, Direct Rap1/Talin1 interaction regulates platelet and neutrophil integrin activity in mice, Blood., 132, 2754, 10.1182/blood-2018-04-846766 Kuijpers, 2009, LAD-1/variant syndrome is caused by mutations in FERMT3, Blood., 113, 4740, 10.1182/blood-2008-10-182154