In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine

Food and Chemical Toxicology - Tập 75 - Trang 39-49 - 2015
M. Gajewska1,2, A. Paini1, J.V. Sala Benito1, J. Burton1, A. Worth1, C. Urani3, H. Briesen4, K.-W. Schramm2,5
1Systems Toxicology Unit, EURL ECVAM, Institute for Health and Consumer Protection, European Commission, Joint Research Centre, Ispra, VA 21027, Italy
2Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Department für Biowissenschaften, TUM, Weihenstephaner Steig 23, Freising 85350, Germany
3Department of Earth and Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, Milano, Italy
4Wissenschaftszentrum Weihenstephan für Ernährung, Landnutzung und Umwelt, Lehrstuhl für Systemverfahrenstechnik, TUM, Weihenstephaner Steig 23, Freising 85350, Germany
5Molecular EXposomics (MEX), Helmholtz Zentrum München – German Research Center for Environmental Health (GmbH), Ingolstädter Landstr.1, Neuherberg D-85764, Germany

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