In vitro calibration of a system for measurement of in vivo convective heat transfer coefficient in animals

Springer Science and Business Media LLC - Tập 5 - Trang 1-11 - 2006
Chanchana Tangwongsan1, Louay Chachati2, John G Webster3, Patrick V Farrell4
1Department of Electrical Engineering, Chulalongkorn University, Bangkok, Thailand
2Department of Electrical and Electronic Engineering, University of Aleppo, Aleppo, Syria
3Department of Biomedical Engineering, University of Wisconsin — Madison, USA
4Department of Mechanical Engineering, University of Wisconsin, Madison, USA

Tóm tắt

We need a sensor to measure the convective heat transfer coefficient during ablation of the heart or liver. We built a minimally invasive instrument to measure the in vivo convective heat transfer coefficient, h in animals, using a Wheatstone-bridge circuit, similar to a hot-wire anemometer circuit. One arm is connected to a steerable catheter sensor whose tip is a 1.9 mm × 3.2 mm thin film resistive temperature detector (RTD) sensor. We used a circulation system to simulate different flow rates at 39°C for in vitro experiments using distilled water, tap water and saline. We heated the sensor approximately 5°C above the fluid temperature. We measured the power consumed by the sensor and the resistance of the sensor during the experiments and analyzed these data to determine the value of the convective heat transfer coefficient at various flow rates. From 0 to 5 L/min, experimental values of h in W/(m2·K) were for distilled water 5100 to 13000, for tap water 5500 to 12300, and for saline 5400 to 13600. Theoretical values were 1900 to 10700. We believe this system is the smallest, most accurate method of minimally invasive measurement of in vivo h in animals and provides the least disturbance of flow.

Tài liệu tham khảo

Chen SA, Chiang CE, Tai CT, Lee H, Chang MS: Future ablation concepts of tachyarrhythmias. J Cardiovasc Electrophysiol 1995, 6: 852–862. Haissaguerre M, Jais PD, Shah DC, Gencel L, Pradeau V, Garrigues S, Chouairi S, Hocini M, Le Metayer P, Roudaut R, Clementy J: Right and left atrial radiofrequency catheter therapy of paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol 1996, 7: 1132–1144. Lau CP, Tai YT, Lee PWH: The effects of radiofrequency ablation versus medical therapy on the quality-of-life and exercise capacity in patients with accessory pathway-medical supraventricular tachycardia: a treatment comparison study. PACE 1995, 18: 424–432. Mirotznik MS, Demazumder DT, Jones JR, Schwartzman DS: Heating distribution of multipolar radiofrequency ablation catheters. Proc 19th Int Conf IEEE Eng Med Biol Soc 1997, 1: 157–160. Stuart TP, Nicholson IA, Nunn GR, Rees A, Trieu L, Daly MPJ, Wallace EM, Ross DL: Effect of atrial radiofrequency ablation designed to cure atrial fibrillation on atrial mechanical function. J Cardiovasc Electrophysiol 2000, 11: 77–82. Haines DE: The biophysics of radiofrequency catheter ablation in the heart: the importance of temperature monitoring. PACE 1993, 16: 586–591. Tungjitkusolmun S, Vorperian VR, Bhavaraju N, Cao HJ, Tsai JZ, Webster JG: Guidelines for predicting lesion size at common endocardial locations during radio-frequency ablation. IEEE Trans Biomed Eng 2001, 48: 194–201. Nerem RM, Seed WA, Wood NB: An experimental study of the velocity distribution and transition to turbulence in the aorta. J Fluid Mech 1972, 52: 137–160. Paulsen PK, Nissen T: Patient safety unit for a hot-film anemometer, used for blood-velocity determination in humans. Med Biol Eng Comput 1982, 20: 625–627. Yamaguchi T, Kikkawa S, Yoshikawa T, Tanishita K, Sugawara M: Measurement of turbulence intensity in the center of the canine ascending aorta with a hot-film anemometer. J Biomed Eng 1983, 105: 177–187. Paulsen PK, Hasenkam JM, Nygaard H, Gormsen J: Analysis of the dynamic properties of a hot-film anemometer system for blood velocity measurements in humans. Med Biol Eng Comput 1987, 25: 195–200. Cao H, Speidel MA, Tsai JZ, Van Lysel MS, Vorperian VR, Webster JG: FEM analysis of predicting electrode-myocardium contact from RF cardiac catheter ablation system impedance. IEEE Trans Biomed Eng 2002, 49: 520–526. Jain MK, Wolf PD: Finite element analysis predicts dose-response relationship for constant power and temperature controlled radiofrequency ablation. Proc 19th Int Conf-IEEE Eng Med Biol Soc 1997, 1: 165–168. Bhavaraju NC: Heat transfer modeling during cardiac ablation in swine myocardium. PhD thesis. University of Texas at Austin, Department of Biomedical Engineering; 1999. Tungjitkusolmun S, Woo EJ, Cao H, Tsai JZ, Vorperian VR, Webster JG: Thermal-electric finite element modeling for radio frequency cardiac ablation: effects of changes in myocardial properties. Med Biol Eng Comput 2000, 38: 562–568. Tangwongsan C, Will JA, Webster JG, Meredith KL Jr, Mahvi DM: In vivo measurement of swine endocardial convective heat transfer coefficient. IEEE Trans Biomed Eng 2004, 51: 1478–1486. Bronzino JD: The Biomedical Engineering Handbook. Volume I. 1st edition. New York, CRC Press; 1995. Hayt WH Jr: Engineering electromagnetics. 5th edition. New York, McGraw-Hill international edition; 1989. Lide DR: Handbook of Chemistry and Physics. 81st edition. New York, CRC Press; 2000–2001. Lenntech TDS and electrical conductivity [http://www.lenntech.com/tds-ec_engels.htm] Freire RCS, Deep GS, Oliveira A: Effect of operational amplifier parameters on the performance of feedback structures with thermoresistive sensors. IEEE Instrum Meas Technol Conf 1997, 898–903. Holman JP: Heat Transfer. 6th edition. New York, McGraw-Hill; 1986. RTD table for DIN EN60751 for class A and class B In Handbook and Encyclopedia: Temperature. MM, omega.com; 2000:z-251-z-255.