In vitro biological properties and health benefits of a novel sulfated polysaccharide isolated from Cymodocea nodosa

Lipids in Health and Disease - Tập 16 - Trang 1-11 - 2017
Rihab Ben Abdallah Kolsi1, Bochra Gargouri2, Sameh Sassi3, Donyez Frikha4, Saloua Lassoued2, Karima Belghith1
1Laboratory of Plant Biotechnology Applied to the Improvement of Cultures, Faculty of Sciences of Sfax, Sfax, Tunisia
2Biotechnology Unit and Pathologies, Superior Institute of Biotechnology of Sfax, Sfax, Tunisia
3Unité de Biodiversité et Valorisation des Bioressources en zones arides, Faculté des Sciences de Gabes, Gabes, Tunisia
4Biodiversity Unit and aquatic ecosystems, Faculty of Sciences of Sfax, Sfax, Tunisia

Tóm tắt

During the last few decades, there has been a growing interest in the search for novel bioactive compounds from marine origins. The present study is the first to determine the molecular characterization which it was deposited in the genebank database, to investigate and evaluate the biological properties of sulfated polysaccharide from Cymodocea nodosa (CNSP) seagrass. The results revealed that CNSP had high activity in total antioxidant assay (59.03 mg ascorbic acid equivalents/g extract), reducing power (OD = 0.3), DPPH radical scavenging (IC50 = 1.22 mg/ml) and ABTS radical scavenging (IC50 = 1.14 mg/ml). It was also noted to exhibit antimicrobial activity against a wide range of microorganisms, with important inhibition zones. The results revealed that CNSP was able to inhibit the proliferation of Hela cell lines with a dose-dependent manner. Overall, the results presented in this study demonstrate that CNSP has several attractive antioxidant, antimicrobial and antiproliferative properties with potential benefits towards health.

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