In vitro and in vivo postprandial hypoglycemic effects and comprehensive metabolite profiling of Dangjo chili pepper (Capsicum annuum L. cv. Dangjo)

Cho, 2020, Development of a database of capsaicinoid contents in foods commonly consumed in Korea, Food Sciences and Nutrition, 8, 4611 Ding, 2010, Inhibition of AP-1 and MAPK signaling and activation of Nrf2/ARE pathway by quercitrin, International Journal of Oncology, 36, 59 Dobón-Suárez, 2021, Influence of the phenological stage and harvest date on the bioactive compounds content of green pepper fruit, Molecules, 26, 10.3390/molecules26113099 Galicia-Garcia, 2020, Pathophysiology of type 2 diabetes mellitus, International Journal of Molecular Sciences, 21, 10.3390/ijms21176275 Gong, 2020, Inhibitors of α‐amylase and α‐glucosidase: Potential linkage for whole cereal foods on prevention of hyperglycemia, Food Sciences and Nutrition, 8, 6320 Honden, 2017, Inhibitory effects on increase in postprandial blood glucose level by intake of new variety of functional pepper (Capsicum annuum cv. Dangjo), Journal of New Remedies & Clinics, 66, 243 Kim, 2017, Metabolite profiling of peppers of various colors reveals relationships between tocopherol, carotenoid, and phytosterol content, Journal of Food Science, 82, 2885, 10.1111/1750-3841.13968 Kim, 2020, Metabolomics approach to identify the active substances influencing the antidiabetic activity of Lagerstroemia species, Journal of Functional Foods, 64, 10.1016/j.jff.2019.103684 Kumar, 2011, alpha-glucosidase inhibitors from plants: A natural approach to treat diabetes, Pharmacy Review, 5, 19, 10.4103/0973-7847.79096 Kwon, 2008, Effect of fructose or sucrose feeding with different levels on oral glucose tolerance test in normal and type 2 diabetic rats, Nutrition research and practice, 2, 252, 10.4162/nrp.2008.2.4.252 Lee, 2017, Anti-oxidative and anti-proliferative effect of 70% ethanol extracts from green pepper (Capsicum annuum L. Cv. Dangzo), The Korean journal of food and nutrition, 30, 1127 Lee, 2019, Inhibition of starch degrading enzyme activity and quality characteristics of noodle pasta with DangZo pepper (Capsicum annuum L. Cv. Dangzo), Journal of the Korean Society of Food Science and Nutrition, 48, 987, 10.3746/jkfn.2019.48.9.987 Malunga, 2016, Inhibition of intestinal alpha-glucosidase and glucose absorption by feruloylated arabinoxylan mono- and oligosaccharides from corn bran and wheat aleurone, J Nutr Metab, 10.1155/2016/1932532 Materska, 2005, Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L), Journal of Agricultural and Food Chemistry, 53, 1750, 10.1021/jf035331k Mei, 2021, Sulfation of quercitrin, epicatechin and rutin by human cytosolic sulfotransferases (SULTs): Differential effects of SULT genetic polymorphisms, Planta Medica, 87, 498, 10.1055/a-1351-0618 Nair, 2013, In vitro studies on alpha amylase and alpha glucosidase inhibitory activities of selected plant extracts, European Journal of Experimental Biology, 3, 128 Oki, 2000, Evaluation of α-glucosidase inhibition by using an immobilized assay system, Biological and Pharmaceutical Bulletin, 23, 1084, 10.1248/bpb.23.1084 Oki, 1999, Inhibitory effect of α-glucosidase inhibitors varies according to its origin, Journal of Agricultural and Food Chemistry, 47, 550, 10.1021/jf980788t Olatunji, 2018, The suitability of chili pepper (Capsicum annuum L.) for alleviating human micronutrient dietary deficiencies: A review, Food Sciences and Nutrition, 6, 2239 Park, 2017, Improvement and distribution of vegetables expended functional content, Horticultural Science and Technology, 35 Park, 2022, Effect of mori ramulus on the postprandial blood glucose levels and inflammatory responses of healthy subjects subjected to an oral high-fat/sucrose challenge: A double-blind, randomized, crossover clinical trial, Biomedicine & Pharmacotherapy, 146, 10.1016/j.biopha.2021.112552 Park, 2016, In vitro and in vivo α-glucosidase and α-amylase inhibitory effects of the water extract of leaves of pepper (Capcicum annuum L. cultivar Dangjo) and the active constituent Luteolin 7-o-glucoside, Journal of Food Biochemistry, 40, 696, 10.1111/jfbc.12252 Poovitha, 2016, In vitro and in vivo alpha-amylase and alpha-glucosidase inhibiting activities of the protein extracts from two varieties of bitter gourd (Momordica charantia L.), BMC Complementary and Alternative Medicine, 16, 185, 10.1186/s12906-016-1085-1 Shin, 2019, Optimization of in vitro carbohydrate digestion by mammalian mucosal α-glucosidases and its applications to hydrolyze the various sources of starches, Food Hydrocolloids, 87, 470, 10.1016/j.foodhyd.2018.08.033 Sun, 2020, Dietary polyphenols as antidiabetic agents: Advances and opportunities, Food Frontiers, 1, 18, 10.1002/fft2.15 Trinh, 2022, Quercetin and quercitrin from agrimonia pilosa ledeb inhibit the migration and invasion of colon cancer cells through the JNK signaling pathway, Pharmaceuticals, 15, 10.3390/ph15030364 Tundis, 2011, Comparative study on the chemical composition, antioxidant properties and hypoglycaemic activities of two Capsicum annuum L. cultivars (Acuminatum small and Cerasiferum), Plant Foods for Human Nutrition, 66, 261, 10.1007/s11130-011-0248-y Westphal, 2003, Insulin and oral hypoglycemic agents should not be used in combination in the treatment of type 2 diabetes, Archives of Internal Medicine, 163, 1783, 10.1001/archinte.163.15.1783 Yi, 2019, Comparison of metabolite levels and antioxidant activity among pepper cultivars, Korean Journal of Breeding Science, 51, 326, 10.9787/KJBS.2019.51.4.326 Yu, 2011, Novel peptides derived from egg white protein inhibiting alpha-glucosidase, Food Chemistry, 129, 1376, 10.1016/j.foodchem.2011.05.067 Zhang, 2022, Antidiabetic potential of Catechu via assays for alpha-glucosidase, alpha-amylase, and glucose uptake in adipocytes, Journal of Ethnopharmacology, 291, 10.1016/j.jep.2022.115118 Zhang, 2020, Molecular mechanisms underlying the absorption of aglycone and glycosidic flavonoids in a Caco-2 BBe1 cell model, ACS Omega, 5, 10782, 10.1021/acsomega.0c00379 Zheng, 2021, Biological activities of some new secondary metabolites isolated from endophytic fungi: A review study, International Journal of Molecular Sciences, 22, 10.3390/ijms22020959 Zhu, 2015