In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

Barrow, 1991, Solution structures of β peptide and its constituent fragments: relation to amyloid deposition, Science, 253, 179, 10.1126/science.1853202

Brewer, 1989, Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen, Brain Research, 494, 65, 10.1016/0006-8993(89)90144-3

Burdick, D., Soreghan, B., Kosmoski, J., Knauer, M., Henschen, A., Yates, J., Cotman, C. and Glabe, C., Assembly and aggregation properties of synthetic Alzheimer's A4/ß amyloid peptide analogs, submitted.

Cotman, 1991, The role of misdirected plasticity in plaque biogenesis and Alzheimer's disease pathology, 222

Esch, 1990, Cleavage of amyloid β peptide during constitutive processing of its precursor, Science, 248, 1122, 10.1126/science.2111583

Geddes, 1986, Senile plaques as aberrant sprout-stimulating structures, Exp. Neurol., 94, 767, 10.1016/0014-4886(86)90254-2

Glabe, 1990, Semiautomatic synthesis of large peptides with a continuous flow instrument using Fmoc-amino acid chemistry, Technique, 2, 138

Hilbich, 1991, Aggregation and secondary structure of synthetic amyloid ßA4 peptides of Alzheimer's disease, J. Mol. Biol., 218, 149, 10.1016/0022-2836(91)90881-6

Ishiura, 1991, Proteolytic cleavage of the Alzheimer's disease amyloid A4 precursor protein, J. Neurochem., 56, 363, 10.1111/j.1471-4159.1991.tb08160.x

Joachim, 1991, Antibodies to non-beta regions of the beta-amyloid precursor protein detect a subset of senile plaques, Am. J. Pathol., 138, 373

Koh, 1990, ß-Amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage, Brain Research, 533, 315, 10.1016/0006-8993(90)91355-K

Masters, 1985, Amyloid plaque core protein in Alzheimer disease and Down syndrome, 82, 4245

Pike, C.J., Walencewicz, A.J., Glabe, C.G. and Cotman, C.W., Aggregation-related toxicity of synthetic ß-amyloid protein in hippocampal cultures, Eur. J. Pharmacol., in press.

Roher, 1991, ß-Amyloid from Alzheimer disease brain inhibits sprouting and survival of sympathetic neurons, Biochem. Biophys. Res. Commun., 174, 572, 10.1016/0006-291X(91)91455-L

Sisodia, 1990, Evidence that ß-amyloid protein in Alzheimer's disease is not derived by normal processing, Science, 248, 492, 10.1126/science.1691865

Tate-Ostroff, 1989, Identification of cellular and extracellular sites of amyloid precursor protein extracytoplasmic domain in normal and Alzheimer disease brains, 86, 745

Whitson, 1990, ß-Amyloid protein promotes neuritic branching in hippocampal cultures, Neurosci. Lett., 110, 319, 10.1016/0304-3940(90)90867-9

Whitson, 1989, Amyloid β protein enhances the survival of hippocampal neurons in vitro, Science, 243, 1488, 10.1126/science.2928783

Yankner, 1990, Nerve growth factor potentiates the neurotoxicity of β amyloid, 87, 9020

Yankner, 1989, Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease, Science, 245, 417, 10.1126/science.2474201

Yankner, 1990, Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides, Science, 250, 279, 10.1126/science.2218531