Improved one-pot synthesis of N, N-diisopropyl-3-(2-Hydroxy-5-methylphenyl)-3-phenyl propanamide; a key intermediate for the preparation of racemic Tolterodine

Sustainable Chemical Processes - Tập 2 - Trang 1-6 - 2014
Garaga Srinivas1,2, Ambati V Raghava Reddy1, Koilpillai Joseph Prabahar1, Korrapati venkata vara Prasada Rao1, Paul Douglas Sanasi2, Raghubabu Korupolu2
1Chemical Research and Development Department, Aurobindo Pharma Ltd, Hyderabad, India
2Engineering Chemistry Department, AU college of Engineering, Andhra University, Visakhapatnam, India

Tóm tắt

An improved, cost effective process for the synthesis of N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamide; a key intermediate for the preparation of Tolterodine and its related substances were described. The process features one pot synthesis employing inexpensive reagents.

Tài liệu tham khảo

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