Implant‐induced intraperitoneal inflammatory angiogenesis is attenuated by fluvastatin
Tóm tắt
1. Statins, 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase (HMG‐CoA) inhibitors, exert anti‐inflammatory, anti‐oxidant and anti‐angiogenic effects. These effects are associated with downregulation of pro‐inflammatory/pro‐angiogenic molecules and upregulation of endothelial nitric oxide synthase (e‐NOS) expression/nitric oxide (NO) production.
2. Using the murine sponge model to induce chronic intraperitoneal inflammatory response, we evaluated the inflammatory components, angiogenic and NO production of the fibrovascular tissue, and their modulation by fluvastatin.
3. Our results showed that fluvastatin (0.6 and 6 mg/kg per day) inhibited haemoglobin (Hb) content 4.9 ± 0.4 (
4. The inhibitory function of fluvastatin on key components of intraperitoneal inflammatory angiogenesis shown in the present study is clearly associated with the modulatory effects of this statin on vascular endothelial growth factor, TNF‐α and NO production.
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Tài liệu tham khảo
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