Impact of the extracellular matrix on plasticity in juvenile and adult brains
Tóm tắt
In the higher vertebrate brain, the delicate balance between structural stabilization and remodeling of synaptic networks changes over the life span. The juvenile brain is characterized by high structural plasticity. A critical step in brain maturation is the occurrence of the extracellular matrix (ECM) that structurally stabilizes neuronal tissue restricting the potential for neuronal remodeling and regeneration. Current research has only begun to understand how this putative limitation of adult neuronal plasticity might impact on learning-related plasticity, lifelong memory reformation and higher cognitive functions. In this review, we summarize recent evidence that recognizes the ECM and its activity-dependent modulation as a key regulator of learning-related plasticity in the adult brain. Experimental modulation of the ECM in local neuronal circuits further opens short-term windows of activity-dependent reorganization, promoting complex forms of cognitive flexible adaptation of valuable behavioral options. This further bears implications for guided neuroplasticity with regenerative and therapeutic potential.
Tài liệu tham khảo
Gundelfinger ED, Frischknecht R, Choquet D, Heine M (2010) Converting juvenile into adult plasticity: a role for the brain’s extracellular matrix. Eur J Neurosci 31:2156–2165
Pizzorusso T, Medini P, Berardi N, Chierzi S, Fawcett JW, Maffei L (2002) Reactivation of ocular dominance plasticity in the adult visual cortex. Science 298:1248–1251
Gogolla N, Caroni P, Lüthi A, Herry C (2009) Perineuronal nets protect fear memories from erasure. Science 325:1258–1261
Dityatev A, Schachner M, Sonderegger P (2010) The dual role of the extracellular matrix in synaptic plasticity and homeostasis. Nat Rev Neurosci 11:735–746
Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED (2009) Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nat Neurosci 12:897–904
Valenzuela JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, Frischknecht R (2014) Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. Philos Trans R Soc Lond B Biol Sci 369(1654):20130606
Huntley GW (2012) Synaptic circuit remodelling by matrix metalloproteinases in health and disease. Nat Rev Neurosci 13(11):743–757
Dityatev A, Wehrle-Haller B, Pitkänen A (2014) Brain extracellular matrix in health and disease. Prog Brain Res 214:xiii–xvii
Happel MFK, Niekisch H, Castiblanco Rivera LL, Ohl FW, Deliano M, Frischknecht R (2014) Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. Proc Natl Acad Sci USA 111:2800–2805
Romberg C, Yang S, Melani R, Andrews MR, Horner AE, Spillantini MG, Bussey TJ, Fawcett JW, Pizzorusso T, Saksida LM (2013) Depletion of perineuronal nets enhances recognition memory and long-term depression in the perirhinal cortex. J Neurosci 33:7057–7065