Tác động của sự biến thiên trong việc định hình giữa các độc giả lên radiomics kết cấu của di căn gan do ung thư đại trực tràng
Tóm tắt
Radiomics được kỳ vọng sẽ cải thiện quản lý di căn ung thư đại trực tràng (CRC). Chúng tôi nhằm đánh giá tác động của việc định hìnhlesion ở gan như một nguồn biến thiên lên các đặc trưng radiomic (RF).
Sau khi được sự phê duyệt của Ủy ban Đạo đức, 70 di căn gan ở 17 bệnh nhân CRC đã được phân đoạn trên các hình ảnh chụp cắt lớp vi tính có tăng cường bởi thuốc tương phản do hai bác sĩ nội trú và được kiểm tra bởi các bác sĩ chẩn đoán hình ảnh có kinh nghiệm. Các RF từ ma trận đồng xuất cấp xám và ma trận độ dài chạy đã được trích xuất từ các vùng quan tâm ba chiều (3D) và hai chiều (2D) lớn nhất. Biến thiên giữa các độc giả được đánh giá bằng hệ số Dice và khoảng cách Hausdorff, trong khi tác động của nó đối với các RF được đánh giá bằng sự thay đổi tương đối trung bình (MRC) và hệ số tương đồng trong nhóm (ICC). Đối với tổn thương chính của mỗi bệnh nhân, một độc giả cũng phân đoạn một ROI tròn trên cùng một hình ảnh được sử dụng cho ROI 2D.
Sự đồng thuận định hình giữa các độc giả tốt nhất được quan sát thấy đối với ROI 2D theo cả hệ số Dice (trung vị 0.85, khoảng giữa 0.78–0.89) và khoảng cách Hausdorff (0.21 mm, 0.14–0.31 mm). So sánh các giá trị RF, MRC dao động trong khoảng 0–752% đối với 2D và 0–1567% đối với 3D. Đối với 24/32 RFs (75%), MRC thấp hơn đối với 2D so với 3D. Một ICC > 0.90 đã được quan sát thấy cho nhiều RF hơn đối với 2D (53%) so với 3D (34%). Chỉ có 2/32 RFs (6%) cho thấy sự biến thiên giữa ROI 2D và ROI tròn cao hơn sự biến thiên giữa các độc giả.
Từ khóa
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