Impact of Cranberries on Gut Microbiota and Cardiometabolic Health: Proceedings of the Cranberry Health Research Conference 2015

US Department of Health and Human Services; US Department of Agriculture, 2015, Scientific report of the 2015 Dietary Guidelines Advisory Committee [Internet], US Department of Health and Human Services Blumberg, 2013, Cranberries and their bioactive constituents in human health, Adv Nutr, 4, 618, 10.3945/an.113.004473 Kaspar, 2015, A randomized, double-blind, placebo-controlled trial to assess the bacterial anti-adhesion effects of cranberry extract beverages, Food Funct, 6, 1212, 10.1039/C4FO01018C Shmuely, 2007, Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor, Mol Nutr Food Res, 51, 746, 10.1002/mnfr.200600281 Zhang, 2005, Efficacy of cranberry juice on Helicobacter pylori infection: a double-blind, randomized placebo-controlled trial, Helicobacter, 10, 139, 10.1111/j.1523-5378.2005.00301.x Shmuely, 2012, Cranberry components for the therapy of infectious disease, Curr Opin Biotechnol, 23, 148, 10.1016/j.copbio.2011.10.009 Bodet, 2008, Potential oral health benefits of cranberry, Crit Rev Food Sci Nutr, 48, 672, 10.1080/10408390701636211 Feldman, 2012, Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages: Synergy between proanthocyanidins and licochalcone A, J Appl Microbiol, 113, 438, 10.1111/j.1365-2672.2012.05329.x LaPlante, 2012, Effects of cranberry extracts on growth and biofilm production of Escherichia coli and Staphylococcus species, Phytother Res, 26, 1371, 10.1002/ptr.4592 Ulrey, 2014, Cranberry proanthocyanidins have anti-biofilm properties against Pseudomonas aeruginosa, BMC Complement Altern Med, 14, 499, 10.1186/1472-6882-14-499 Weiss, 2005, Cranberry juice constituents affect influenza virus adhesion and infectivity, Antiviral Res, 66, 9, 10.1016/j.antiviral.2004.12.011 Patel, 2011, Proanthocyanidin-rich extracts from cranberry fruit (Vaccinium macrocarpon Ait.) aelectively inhibit the growth of human pathogenic fungi Candida spp. and Cryptococcus neoformans, J Agric Food Chem, 59, 12864, 10.1021/jf2035466 Rane, 2014, Cranberry-derived proanthocyanidins prevent formation of Candida albicans biofilms in artificial urine through biofilm- and adherence-specific mechanisms, J Antimicrob Chemother, 69, 428, 10.1093/jac/dkt398 Feliciano, 2015, Methods to determine effects of cranberry proanthocyanidins on extraintestinal infections: relevance for urinary tract health, Mol Nutr Food Res, 59, 1292, 10.1002/mnfr.201500108 Feliciano, 2014, Ratio of “A-type” to “B-type” proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells, J Agric Food Chem, 62, 3919, 10.1021/jf403839a Sánchez-Patán, 2015, Comparative in vitro fermentations of cranberry and grape seed polyphenols with colonic microbiota, Food Chem, 183, 273, 10.1016/j.foodchem.2015.03.061 Ou, 2014, Microbial catabolism of procyanidins by human gut microbiota, Mol Nutr Food Res, 58, 2196, 10.1002/mnfr.201400243 Polak, 2013, Protective potential of non-dialyzable material fraction of cranberry juice on the virulence of P. gingivalisF. nucleatum mixed infection, J Periodontol, 84, 1019, 10.1902/jop.2012.120331 Kim, 2015, Cranberry flavonoids modulate cariogenic properties of mixed-species biofilm through exopolysaccharides-matrix disruption, PLOS ONE, 10, 10.1371/journal.pone.0145844 Pinzón-Arango, 2011, Impact of cranberry juice and proanthocyanidins on the ability of Escherichia coli to form biofilms, Food Sci Biotechnol, 20, 1315, 10.1007/s10068-011-0181-8 Sun, 2015, Cranberry (Vaccinium macrocarpon) oligosaccharides decrease biofilm formation by uropathogenic Escherichia coli, J Funct Foods, 17, 235, 10.1016/j.jff.2015.05.016 Hotchkiss, 2015, Cranberry xyloglucan structure and inhibition of Escherichia coli adhesion to epithelial cells, J Agric Food Chem, 63, 5622, 10.1021/acs.jafc.5b00730 Zafriri, 1989, Inhibitory activity of cranberry juice on adherence of type 1 and type P fimbriated Escherichia coli to eucaryotic cells, Antimicrob Agents Chemother, 33, 92, 10.1128/AAC.33.1.92 Pinzón-Arango, 2009, Role of cranberry on bacterial adhesion forces and implications for Escherichia coli–uroepithelial cell attachment, J Med Food, 12, 259, 10.1089/jmf.2008.0196 Signoretto, 2012, Functional foods and strategies contrasting bacterial adhesion, Curr Opin Biotechnol, 23, 160, 10.1016/j.copbio.2011.08.006 Liu, 2006, Role of cranberry juice on molecular-scale surface characteristics and adhesion behavior of Escherichia coli, Biotechnol Bioeng, 93, 297, 10.1002/bit.20675 de Llano, 2015, Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures, Int J Mol Sci, 16, 12119, 10.3390/ijms160612119 Pastorelli, 2013, Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics, Front Immunol [Internet], 10.3389/fimmu.2013.00280 Wong, 2016, Deleterious effect of p-Cresol on human colonic epithelial cells prevented by proanthocyanidin-containing polyphenol extracts from fruits and proanthocyanidin bacterial metabolites, J Agric Food Chem, 64, 3574, 10.1021/acs.jafc.6b00656 Johansson, 2011, Composition and functional role of the mucus layers in the intestine, Cell Mol Life Sci, 68, 3635, 10.1007/s00018-011-0822-3 Yusuf, 2004, Quantitative changes in gastric mucosal glycoproteins: effect of cholinergic agonist and vagal nerve stimulation in the rat, Neurogastroenterol Motil, 16, 613, 10.1111/j.1365-2982.2004.00580.x Fallon, 2002, IL-4 induces characteristic Th2 responses even in the combined absence of IL-5, IL-9, and IL-13, Immunity, 17, 7, 10.1016/S1074-7613(02)00332-1 Finkelman, 1997, Cytokine regulation of host defense against parasitic gastrointestinal nematodes: lessons from studies with rodent models, Annu Rev Immunol, 15, 505, 10.1146/annurev.immunol.15.1.505 McKenzie, 1998, A distinct role for interleukin-13 in Th2-cell-mediated immune responses, Curr Biol, 8, 339, 10.1016/S0960-9822(98)70134-4 Birchenough, 2015, New developments in goblet cell mucus secretion and function, Mucosal Immunol, 8, 712, 10.1038/mi.2015.32 Pendyala, 2012, A high-fat diet is associated with endotoxemia that originates from the gut, Gastroenterology, 142, 1100, 10.1053/j.gastro.2012.01.034 Martinez-Medina, 2014, Western diet induces dysbiosis with increased E coli in CEABAC10 mice, alters host barrier function favouring AIEC colonisation, Gut, 63, 116, 10.1136/gutjnl-2012-304119 Piya, 2013, Metabolic endotoxaemia: is it more than just a gut feeling?, Curr Opin Lipidol, 24, 78, 10.1097/MOL.0b013e32835b4431 Cani, 2008, Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice, Diabetes, 57, 1470, 10.2337/db07-1403 Martinez-Medina, 2014, Escherichia coli in chronic inflammatory bowel diseases: an update on adherent invasive Escherichia coli pathogenicity, World J Gastrointest Pathophysiol, 5, 213, 10.4291/wjgp.v5.i3.213 Anhê, 2015, A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice, Gut, 64, 872, 10.1136/gutjnl-2014-307142 Denis, 2015, Prevention of oxidative stress, inflammation and mitochondrial dysfunction in the intestine by different cranberry phenolic fractions, Clin Sci, 128, 197, 10.1042/CS20140210 Pierre, 2014, Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition, JPEN J Parenter Enteral Nutr, 38, 107, 10.1177/0148607112473654 Pierre, 2013, Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition, JPEN Parenter Enteral Nutr, 37, 401, 10.1177/0148607112463076 Hermsen, 2009, Parenteral feeding depletes pulmonary lymphocyte populations, JPEN Parenter Enteral Nutr, 33, 535, 10.1177/0148607109332909 Kudsk, 2007, Enteral feeding of a chemically defined diet preserves pulmonary immunity but not intestinal immunity: the role of lymphotoxin beta receptor, JPEN J Parenter Enteral Nutr, 31, 477, 10.1177/0148607107031006477 Mosenthal, 2002, Elemental and intravenous total parenteral nutrition diet-induced gut barrier failure is intestinal site specific and can be prevented by feeding nonfermentable fiber, Crit Care Med, 30, 396, 10.1097/00003246-200202000-00022 Wu, 1999, Route and type of nutrition influence IgA-mediating intestinal cytokines, Ann Surg, 229, 662, 10.1097/00000658-199905000-00008 Nantz, 2013, Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study, Nutr J, 12, 161, 10.1186/1475-2891-12-161 Diard, 2010, Pathogenicity-associated islands in extraintestinal pathogenic Escherichia coli are fitness elements involved in intestinal colonization, J Bacteriol, 192, 4885, 10.1128/JB.00804-10 Johnson, 2005, Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli, Int J Med Microbiol, 295, 383, 10.1016/j.ijmm.2005.07.005 Foxman, 2010, The epidemiology of urinary tract infection, Nat Rev Urol, 7, 653, 10.1038/nrurol.2010.190 Pitout, 2012, Extraintestinal pathogenic Escherichia coli: a combination of virulence with antibiotic resistance, Front Microbiol [Internet], 10.3389/fmicb.2012.00009 Mathison, 2014, Consumption of cranberry beverage improved endogenous antioxidant status and protected against bacteria adhesion in healthy humans: a randomized controlled trial, Nutr Res, 34, 420, 10.1016/j.nutres.2014.03.006 Takahashi, 2013, A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infection, J Infect Chemother, 19, 112, 10.1007/s10156-012-0467-7 Foxman, 2015, Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trial, Am J Obstet Gynecol, 213, 194.e1, 10.1016/j.ajog.2015.04.003 Krueger, 2013, Quantifying and characterizing proanthocyanidins in cranberries in relation to urinary tract health, Anal Bioanal Chem, 405, 4385, 10.1007/s00216-013-6750-3 Rodriguez-Mateos, 2014, Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update, Arch Toxicol, 88, 1803, 10.1007/s00204-014-1330-7 Lee, 2008, Effect of cranberry extracts on lipid profiles in subjects with type 2 diabetes, Diabet Med, 25, 1473, 10.1111/j.1464-5491.2008.02588.x Shidfar, 2012, The effects of cranberry juice on serum glucose, apoB, apoA-I, Lp(a), and Paraoxonase-1 activity in type 2 diabetic male patients, J Res Med Sci, 17, 355 Novotny, 2015, Cranberry juice consumption lowers markers of cardiometabolic risk, including blood pressure and circulating C-reactive protein, triglyceride, and glucose concentrations in adults, J Nutr, 145, 1185, 10.3945/jn.114.203190 Basu, 2011, Low-energy cranberry juice decreases lipid oxidation and increases plasma antioxidant capacity in women with metabolic syndrome, Nutr Res, 31, 190, 10.1016/j.nutres.2011.02.003 Dohadwala, 2011, Effects of cranberry juice consumption on vascular function in patients with coronary artery disease, Am J Clin Nutr, 93, 934, 10.3945/ajcn.110.004242 Flammer, 2013, Polyphenol-rich cranberry juice has a neutral effect on endothelial function but decreases the fraction of osteocalcin-expressing endothelial progenitor cells, Eur J Nutr, 52, 289, 10.1007/s00394-012-0334-4 Ruel, 2013, Evidence that cranberry juice may improve augmentation index in overweight men, Nutr Res, 33, 41, 10.1016/j.nutres.2012.11.002 Ruel, 2006, Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men, Br J Nutr, 96, 357, 10.1079/BJN20061814 Ruel, 2008, Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men, Br J Nutr, 99, 352, 10.1017/S0007114507811986 Ruel, 2009, Plasma matrix metalloproteinase (MMP)-9 levels are reduced following low-calorie cranberry juice supplementation in men, J Am Coll Nutr, 28, 694, 10.1080/07315724.2009.10719803 Ruel, 2005, Changes in plasma antioxidant capacity and oxidized low-density lipoprotein levels in men after short-term cranberry juice consumption, Metabolism, 54, 856, 10.1016/j.metabol.2005.01.031 Wilson, 2008, Favorable glycemic response of type 2 diabetics to low-calorie cranberry juice, J Food Sci, 73, H241, 10.1111/j.1750-3841.2008.00964.x Wilson, 2010, Glycemic responses to sweetened dried and raw cranberries in humans with type 2 diabetes, J Food Sci, 75, H218, 10.1111/j.1750-3841.2010.01800.x Simão, 2013, Reduced-energy cranberry juice increases folic acid and adiponectin and reduces homocysteine and oxidative stress in patients with the metabolic syndrome, Br J Nutr, 110, 1885, 10.1017/S0007114513001207 Rodriguez-Mateos, 2014, Berry (poly)phenols and cardiovascular health, J Agric Food Chem, 62, 3842, 10.1021/jf403757g Kim, 2011, Effects of freeze-dried cranberry powder on serum lipids and inflammatory markers in lipopolysaccharide treated rats fed an atherogenic diet, Nutr Res Pract, 5, 404, 10.4162/nrp.2011.5.5.404 Kim, 2013, Effects of cranberry powder on biomarkers of oxidative stress and glucose control in db/db mice, Nutr Res Pract, 7, 430, 10.4162/nrp.2013.7.6.430 Kim, 2014, Antioxidant effects of cranberry powder in lipopolysaccharide treated hypercholesterolemic rats, Prev Nutr Food Sci, 19, 75, 10.3746/pnf.2014.19.2.075 Corretti, 2002, Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force, J Am Coll Cardiol, 39, 257, 10.1016/S0735-1097(01)01746-6 Feliciano RP, Boeres A, Massaccesi L, Istas G, Ventura R, Nunes dos Santos C, Heiss C, Rodriguez-Mateos A. Identification and quantification of novel cranberry-derived plasma and urinary (poly)phenols. Arch Biochem Biophys. In press. Rodriguez-Mateos, 2016, Cranberry (poly)phenol metabolites correlate with improvements in vascular function: A double-blind, randomized, controlled, dose-response, crossover study, Mol Nutr Food Res, 10.1002/mnfr.201600250 Vlachopoulos, 2010, Prediction of cardiovascular events and all-cause mortality with arterial stiffness, J Am Coll Cardiol, 55, 1318, 10.1016/j.jacc.2009.10.061 Laurent, 2006, Expert consensus document on arterial stiffness: methodological issues and clinical applications, Eur Heart J, 27, 2588, 10.1093/eurheartj/ehl254 Nürnberger, 2002, Augmentation index is associated with cardiovascular risk, J Hypertens, 20, 2407, 10.1097/00004872-200212000-00020 McDougall, 2008, Current developments on the inhibitory effects of berry polyphenols on digestive enzymes, Biofactors, 34, 73, 10.1002/biof.5520340108 Hanhineva, 2010, Impact of dietary polyphenols on carbohydrate metabolism, Int J Mol Sci, 11, 1365, 10.3390/ijms11041365 Pinto, 2010, Potential of cranberry powder for management of hyperglycemia using in vitro models, J Med Food, 13, 1036, 10.1089/jmf.2009.0225 Bozzetto, 2015, Polyphenol-rich diets improve glucose metabolism in people at high cardiometabolic risk: a controlled randomised intervention trial, Diabetologia, 58, 1551, 10.1007/s00125-015-3592-x Dragan, 2015, Polyphenols-rich natural products for treatment of diabetes, Curr Med Chem, 22, 14, 10.2174/0929867321666140826115422 Hartstra, 2015, Insights into the role of the microbiome in obesity and type 2 diabetes, Diabetes Care, 38, 159, 10.2337/dc14-0769 Chambers, 2003, Can cranberry supplementation benefit adults with type 2 diabetes?, Diabetes Care, 26, 2695, 10.2337/diacare.26.9.2695-a Törrönen, 2010, Berries modify the postprandial plasma glucose response to sucrose in healthy subjects, Br J Nutr, 103, 1094, 10.1017/S0007114509992868 Basu, 2012, Strawberries, blueberries, and cranberries in the metabolic syndrome: clinical perspectives, J Agric Food Chem, 60, 5687, 10.1021/jf203488k Duffey, 2013, Adult cranberry beverage consumers have healthier macronutrient intakes and measures of body composition compared to non-consumers: National Health and Nutrition Examination Survey (NHANES) 2005–2008, Nutrients, 5, 4938, 10.3390/nu5124938 Duffey, 2015, Adult consumers of cranberry juice cocktail have lower C-reactive protein levels compared with nonconsumers, Nutr Res, 35, 118, 10.1016/j.nutres.2014.11.005 Martín, 2015, Chemical characterization and chemo-protective activity of cranberry phenolic powders in a model cell culture: response of the antioxidant defenses and regulation of signaling pathways, Food Res Int, 71, 68, 10.1016/j.foodres.2015.02.022 US Highbush Blueberry Council, 2010 California Table Grape Commission, 2015 Jepson, 2012, Cranberries for preventing urinary tract infections, Cochrane Database Syst Rev [Internet], 10.1002/14651858.CD001321.pub5 Pappas, 2009, Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stability, Crit Rev Food Sci Nutr, 49, 741, 10.1080/10408390802145377 White, 2011, Impact of different stages of juice processing on the anthocyanin, flavonol, and procyanidin contents of cranberries, J Agric Food Chem, 59, 4692, 10.1021/jf200149a Grace, 2012, Comparison of health-relevant flavonoids in commonly consumed cranberry products, J Food Sci, 77, H176, 10.1111/j.1750-3841.2012.02788.x Grace, 2013, Stable binding of alternative protein-enriched food matrices with concentrated cranberry bioflavonoids for functional food applications, J Agric Food Chem, 61, 6856, 10.1021/jf401627m Ribnicky, 2014, Effects of a high fat meal matrix and protein complexation on the bioaccessibility of blueberry anthocyanins using the TNO gastrointestinal model (TIM-1), Food Chem, 142, 349, 10.1016/j.foodchem.2013.07.073 Feliciano, 2012, Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins, Food Chem, 135, 1485, 10.1016/j.foodchem.2012.05.102 Reed, 2005, MALDI-TOF mass spectrometry of oligomeric food polyphenols, Phytochemistry, 66, 2248, 10.1016/j.phytochem.2005.05.015 Krueger, 2016, Critical reevaluation of the 4-(dimethylamino)cinnamaldehyde assay: cranberry proanthocyanidin standard is superior to procyanidin A2 dimer for accurate quantification of proanthocyanidins in cranberry products, J Funct Foods, 22, 13, 10.1016/j.jff.2016.01.017 Prior, 2010, Multi-laboratory validation of a standard method for quantifying proanthocyanidins in cranberry powders, J Sci Food Agric, 90, 1473, 10.1002/jsfa.3966 Feliciano, 2012, Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(dimethylamino)cinnamaldehyde assay, J Agric Food Chem, 60, 4578, 10.1021/jf3007213 The Cranberry Institute, 2015 The Cranberry Institute, 2015 Zhang, 2004, GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice, J Agric Food Chem, 52, 222, 10.1021/jf035073r Milbury, 2010, Anthocyanins are bioavailable in humans following an acute dose of cranberry juice, J Nutr, 140, 1099, 10.3945/jn.109.117168 Iswaldi, 2013, Identification of polyphenols and their metabolites in human urine after cranberry-syrup consumption, Food Chem Toxicol, 55, 484, 10.1016/j.fct.2013.01.039 McKay, 2015, Flavonoids and phenolic acids from cranberry juice are bioavailable and bioactive in healthy older adults, Food Chem, 168, 233, 10.1016/j.foodchem.2014.07.062 Walsh, 2016, Liquid chromatography with tandem mass spectrometry quantification of urinary proanthocyanin A2 dimer and its potential use as a biomarker of cranberry intake: liquid chromatography, J Sep Sci, 39, 342, 10.1002/jssc.201500922 Liu, 2015, Profiling the metabolome changes caused by cranberry procyanidins in plasma of female rats using (1) H NMR and UHPLC-Q-Orbitrap-HRMS global metabolomics approaches, Mol Nutr Food Res, 59, 2107, 10.1002/mnfr.201500236