Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome: A MAGNIMS multicentre study

Multiple Sclerosis Journal - Tập 25 Số 3 - Trang 352-360 - 2019
Marloes Hagens1, Jessica Burggraaff1, Iris D. Kilsdonk2, Serena Ruggieri3, Sara Collorone4, Rosa Cortese5,6, Niamh Cawley7, Emilia Sbardella8, Michaela Andělová9, Michael A�mann10, Johanna Lieb11, Patrizià Pantano12, Birgit I. Lissenberg‐Witte13, Joep Killestein1, Celia Oreja‐Guevara14, Jens Wuerfel15, Olga Ciccarelli7, Claudio Gasperini16, Carsten Lukas17, Àlex Rovira18, Frederik Barkhof19, Mike P. Wattjes20
1Department of Neurology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
2Department of Radiology and Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands/Department of Radiology and Nuclear Medicine, Onze Lieve Vrouwen Gasthuis, Amsterdam, The Netherlands
3Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy/Department of Neurosciences, San Camillo-Forlanini Hospital, Rome, Italy
4Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy/NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK
5Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy
6NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK; Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy
7NMR Research Unit, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, London, UK
8Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
9Department of Neurology, University Hospital Basel, Basel, Switzerland
10Department of Neurology, University Hospital Basel, Basel, Switzerland/Medical Image Analysis Center (MIAC), Basel, Switzerland/Division of Neuroradiology, Department of Radiology, University Hospital Basel, Basel, Switzerland
11Division of Neuroradiology/Department of Radiology, University Hospital Basel, Basel, Switzerland
12Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy/Istituto Neurologico Mediterraneo, Neuromed, Pozzilli, Italy
13Department of Epidemiology and Biostatistics, VU University Medical Centre, Amsterdam, The Netherlands
14Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain
15Medical Image Analysis Center (MIAC), Basel, Switzerland/NeuroCure, Charité – Berlin University of Medicine, Berlin, Germany/Department of Biomedical Engineering, University Hospital Basel, Basel, Switzerland
16Department of Neurosciences, San Camillo-Forlanini Hospital, Rome, Italy
17Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St. Josef Hospital, Ruhr University, Bochum, Germany
18Department of Radiology, Hospital Universitari Vall d’Hebron, Barcelona, Spain
19Department of Radiology and Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands/Institutes of Neurology and Healthcare Engineering, UCL Institute of Neurology, London, UK
20Department of Radiology and Nuclear Medicine, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands

Tóm tắt

Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3–6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T ( p = 0.005). For patients, this was 4.18 and 4.40, respectively ( p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training.

Từ khóa


Tài liệu tham khảo

10.1038/nrneurol.2015.157

10.1038/nrneurol.2015.106

10.1001/archopht.121.7.944

10.1093/brain/awm329

10.1001/archneur.61.2.217

10.1093/brain/awv105

10.1212/WNL.0b013e3181feb26f

10.1002/ana.22366

10.1007/s00234-009-0512-0

10.1016/j.nic.2012.02.010

10.1136/jnnp-2013-305246

10.1007/s00330-006-0195-4

10.1007/s00330-009-1705-y

Wattjes MP, 2006, AJNR Am J Neuroradiol, 27, 1794

10.1007/s00415-008-0861-3

10.1002/ana.22490

10.2307/2529310

10.1212/WNL.0b013e31827b1a67

10.1212/WNL.62.2.226

10.1016/j.nic.2008.09.005

10.1016/j.jns.2008.11.009

10.1007/s00330-006-0303-5

10.1016/S1474-4422(15)00393-2

10.1212/WNL.0000000000002975

10.1212/WNL.0000000000003144

10.1007/s00330-012-2619-7

10.1007/s00330-011-2242-z

10.1093/brain/aww037

10.1177/1352458511415305

10.1212/WNL.0b013e31820b7630

10.1007/s00330-013-3080-y

10.1186/s13167-015-0038-y

Thông tin
Thông tin xuất bản

Multiple Sclerosis Journal

Tập 25 Số 3

352-360

Thông tin tác giả