Immunological events in chronic spontaneous urticaria

Wiley - Tập 5 Số 1 - 2015
Marta Ferrer1
1Department of Allergy and Clinical Immunology, Clinica Universidad de Navarra, Pio XII, 36, 31008 Pamplona, Spain.

Tóm tắt

AbstractChronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35–40% of patients. Mast cells and basophils play an important role in this skin condition. Both cells in CSU patients have unique features that differentiate them from basophils and mast cells from healthy donors. In the case of basophils, basopenia is typically found in CSU patients. Basophils from CSU patients also tend to be hyporesponsive to stimuli that act through the IgE receptor, responsive to other stimuli as MCP‐1 or C5a, and hyperesponsive when incubated with sera. Eosinophils are also present in CSU skin biopsies, yet their exact role has not yet been defined. Likewise, endothelial cells also play a function, as indirectly demonstrated by an increase of vasoactive peptides in skin and plasma of CSU patients’ samples. All these facts orchestrate a systemic inflammation response producing a significant increase of several inflammatory markers. Unfortunately, we lack a unitary model that could explain the exact role of each of these players. In this review, we will describe the history and discover the pathway to the present knowledge on the immunological facts of this disease.

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Tài liệu tham khảo

10.1111/all.12313

10.1007/978-3-642-70313-3

Malmros H, 1946, Autoserumtest, Nordisk Med, 29, 150

10.1001/archderm.1983.01650320010007

10.1111/j.1365-2133.2005.06646.x

10.1067/mai.2003.1605

10.1111/j.1365-2133.1986.tb04065.x

10.1111/1523-1747.ep12462239

10.1111/j.1365-2222.1991.tb03198.x

10.1056/NEJM199306033282204

10.1111/1523-1747.ep12338544

10.1172/JCI118325

10.1172/JCI511

10.1016/S0091-6749(97)70071-X

10.1159/000235301

10.1016/S0091-6749(98)70176-9

10.1067/mai.2001.115484

10.1002/(SICI)1521-4141(199904)29:04<1139::AID-IMMU1139>3.0.CO;2-J

10.1096/fj.00-0890hyp

10.1016/S0091-6749(99)70129-6

10.1067/mai.2002.120954

10.1111/j.1365-2222.2009.03256.x

10.1016/j.jaci.2006.02.016

10.1067/mai.2000.104939

10.1159/000066772

10.1046/j.1365-2133.1999.02815.x

10.1111/j.1468-3083.2012.04573.x

10.1111/all.12056

10.1016/j.jaci.2012.01.043

10.1046/j.1365-2133.2000.03664.x

10.1016/j.anai.2011.08.013

10.1016/0140-6736(92)90666-Q

10.1046/j.1365-2133.1998.02033.x

10.1001/archderm.134.1.41

10.1016/0091-6749(83)90096-9

10.1016/S0091-6749(95)70055-2

10.1111/bjd.12991

10.1016/0091-6749(86)90377-5

10.1016/0091-6749(92)90297-F

10.1016/j.clim.2009.05.003

10.1111/j.1365-2222.2010.03582.x

10.1111/j.1398-9995.2011.02704.x

10.1111/cea.12348

10.1111/j.1398-9995.2009.02069.x

10.1046/j.1523-1747.2002.01733.x

10.1155/2015/578383

10.1111/j.1398-9995.1962.tb02937.x

10.1046/j.1365-2222.1997.1630972.x

10.1046/j.1365-2222.1997.1630972.x

10.1046/j.1365-2222.2003.01589.x

10.1038/jid.2008.55

10.1067/mai.2002.123236

10.1034/j.1600-0625.2003.00010.x

10.1111/j.1398-9995.2011.02570.x

10.1111/j.1365-2222.1974.tb01384.x

10.1172/JCI108405

10.1016/S0091-6749(98)70283-0

10.1111/j.1398-9995.1996.tb04545.x

10.1016/0006-2952(89)90031-2

10.1172/JCI115648

10.1111/j.1365-2222.2005.02212.x

10.1111/j.1365-2133.2008.08499.x

10.1034/j.1398-9995.2003.00195.x

10.1038/jid.2015.13

10.1111/j.1365-2222.2005.02380.x

10.1111/j.1365-2222.2011.03789.x

Kasperska‐Zajac A, 2013, Analysis of procalcitonin and CRP concentrations in serum of patients with chronic spontaneous urticaria, Inflamm Res Off J Eur Histamine Res Soc, 62, 309

Kay AB, 2014, Elevations in T‐helper‐2‐initiating cytokines (interleukin‐33, interleukin‐25 and thymic stromal lymphopoietin) in lesional skin from chronic spontaneous (‘idiopathic’) urticaria, Br J Dermatol

10.1016/j.jaut.2014.01.032

10.1016/j.jaci.2005.12.1343

10.1016/j.jaci.2006.08.043

10.1111/j.1398-9995.2007.01514.x

10.1016/j.jaci.2013.04.037

10.1111/j.1365-2133.2008.08880.x

10.1111/j.1398-9995.2008.01859.x

10.1152/physrev.00028.2003

10.1358/dnp.2008.21.7.1255294

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Tập 5 Số 1

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