Immunological and morphological effects of vasectomy in the rabbit

Wiley - Tập 188 Số 3 - Trang 339-350 - 1977
Nancy J. Alexander1,2, Kenneth S. K. Tung1,2
1Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, 87131
2Reproductive Physiology, Oregon Regional Primate Research Center 505 N.W. 185th Avenue, Beaverton, Oregon 97005

Tóm tắt

AbstractHalf of the rabbits developed antisperm antibodies (measured by either indirect immunofluorescence or sperm immobilization tests) after either a unilateral or bilateral vasectomy. The raised antibody levels, particularly six months or longer after vasectomy, often accompanied patchy orchitis. Seminiferous tubules from such animals exhibited sloughed, multinucleated, and immature germinal cells which were engulfed by phagocytic cells. Mononuclear infiltrates were occasionally present. The basal lamina infolded and thickened by means of supernumerary layers and appeared to be endocytosed by cells of the seminiferous tubules. Four months after vasectomy, numerous phagocytic cells were seen to migrate through the intact epithelium of zone 1 in the caput epididymidis, and were particularly prevalent in animals that exhibited testicular damage. These macrophages may serve to present sperm antigens to lymphocytes.

Từ khóa


Tài liệu tham khảo

10.1530/jrf.0.0310399

10.1016/0010-7824(73)90121-2

10.1007/BF00307438

Alexander N. J., 1975, Immunologic and morphologic effects of vasectomy in the rhesus monkey, Fed. Proc., 34, 1692

10.1016/S0015-0282(16)40214-1

10.1016/S0015-0282(16)38520-X

10.1095/biolreprod14.2.118

10.1084/jem.143.2.382

10.1016/0090-1229(76)90024-6

10.1016/S0015-0282(16)40456-5

Davis J. E., 1975, Advances in understanding the effects of vasectomy, Mt. Sinai J. Med. N. Y., 42, 391

Derrick F. C., 1974, Histologic changes in the seminiferous tubules after vasectomy, Fertil. Steril., 25, 649, 10.1016/S0015-0282(16)40568-6

10.1093/biolreprod/3.3.308

10.1530/jrf.0.0420001

10.1002/ar.1091730304

10.1002/ar.1091740407

10.1095/biolreprod13.1.50

10.1095/biolreprod13.1.61

Glover T. D., 1969, Some aspects of function in the epididymis. Experimental occlusion of the epididymis in the rabbit, Int. J. Fertil., 14, 216

Grewel R. S., 1968, Changes in testicle after vasectomy. An experimental study, Int. Surg., 49, 460

Hansen K. B., 1971, Immunofluorescent studies on human spermatozoa. II. Characterization of spermatozoal antigens and their occurrence in spermatozoa from the male partners of infertile couples, Clin. Exp. Immunol., 9, 21

10.1016/0002-9378(68)90307-4

10.1530/jrf.0.0360199

Karnovsky M. J., 1971, Abst. 11th Ann. Mtg. Amer. Soc., 146

10.1530/jrf.0.0340433

Kothari L. K., 1973, Histochemical changes in the testis and epididymis after vasectomy, Int. J. Fertil., 18, 119

10.1016/S0015-0282(16)36854-6

10.1002/aja.1000340203

10.1016/S0065-2776(08)60253-9

10.1084/jem.131.1.1

10.1002/ar.1091640309

10.1530/jrf.0.0070001

10.1530/jrf.0.0210069

10.3181/00379727-131-33972

Tung K. S. K., 1975, Human sperm antigens and antisperm antibodies. I. Studies on vasectomy patients, Clin. Exp. Immunol., 20, 93

Tung K. S. K., 1976, Human sperm antigens and antisperm antibodies. III. Studies on acrosomal antigens, Clin. Exp. Immunol., 24, 292

Tung K. S. K., 1977, The Testis, 491

Tung K. S. K., 1971, Pathogenesis of experimental allergic orchitis. I. Transfer with immune lymph node cells, J. Immunol., 106, 1453, 10.4049/jimmunol.106.6.1453

10.1016/S0015-0282(16)39975-7

Waites G. M. H., 1969, The Gonads, 649

Thông tin
Thông tin xuất bản

Wiley

Tập 188 Số 3

339-350

Thông tin tác giả