Immunologic tolerance maintained by CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Immunological Reviews - Tập 182 Số 1 - Trang 18-32 - 2001
Shimon Sakaguchi1, Noriko Sakaguchi1, Jun Shimizu2, Sayuri Yamazaki1, Toshiko Sakihama1, Masae Itoh3, Yuhshi Kuniyasu4, Takashi Nomura1, Ziaurahman Roeen5, Takeshi Takahashi1
1Dept. of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
2Department of Immunopathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
3Department of Dermatology, University of Tsukuba School of Medicine, Tsukuba, Japan
4Department of Medicine, Jikei Medical University, Tokyo, Japan.
5Department of Immunology, MieUniversity School of Medicine, Tsu, Japan

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Summary: There is accumulating evidence that T‐cell‐mediated dominant control of self‐reactive T‐cells contributes to the maintenance of immunologic self‐tolerance and its alteration can cause autoimmune disease. Efforts to delineate such a regulatory T‐cell population have revealed that CD25+ cells in the CD4+ population in normal naive animals bear the ability to prevent autoimmune disease in vivo and, upon antigenic stimulation, suppress the activation/proliferation of other T cells in vitro. The CD25+ CD4+ regulatory T cells, which are naturally anergic and suppressive, appear to be produced by the normal thymus as a functionally distinct subpopulation of T cells. They play critical roles not only in preventing autoimmunity but also in controlling tumor immunity and transplantation tolerance.

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Immunological Reviews

Tập 182 Số 1

18-32

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