Đặc điểm định vị miễn dịch của các thụ thể estrogen ERα và ERβ trong buồng trứng của chuột gai (Acomys cahirinus) trong quá trình phát triển sau sinh

Journal of Molecular Histology - Tập 38 - Trang 25-32 - 2006
Monika Hułas-Stasiak1, Antoni Gawron1
1Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Lublin, Poland

Tóm tắt

Nghiên cứu này được thiết kế để xác định mô hình biểu hiện của các kiểu thụ thể estrogen (ER) trong các tế bào buồng trứng của Acomys cahirinus trong quá trình phát triển sau sinh. Các nghiên cứu miễn dịch mô học đã phát hiện sự hiện diện của ERα và ERβ trong các tế bào biểu mô sinh dục và mô kẽ. Cả hai kiểu thụ thể ER này cũng được phát hiện trong các tế bào granulosa và trứng của các nang đang phát triển, tuy nhiên, mức độ biểu hiện của ERβ cao hơn so với ERα. Ngược lại với ERβ, protein ERα cũng có mặt trong các tế bào theca. Sự biểu hiện của các thụ thể ER tăng lên theo độ tuổi của động vật, nhưng giảm trong quá trình trưởng thành nang. Hơn nữa, việc định vị miễn dịch các kiểu thụ thể ER trong tế bào hoàng thể cho thấy rằng không phải ERβ, mà là việc biểu hiện ERα được điều chỉnh tăng lên trong suốt quá trình phát triển của hoàng thể. Những nghiên cứu miễn dịch mô học này cho thấy, lần đầu tiên, rằng ERα cũng được biểu hiện trong các tế bào granulosa của chuột và nó có thể là một yếu tố trung gian cho tác động của estrogen trong sự phát triển và phân hóa của các tế bào granulosa.

Từ khóa

#Thụ thể estrogen #ERα #ERβ #buồng trứng #phát triển sau sinh #Acomys cahirinus

Tài liệu tham khảo

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