Immune dysfunction in patients with unexplained repeated abortions

International Journal of Gynecology & Obstetrics - Tập 45 - Trang 221-226 - 1994
S. Konidaris1, K. Papadias1, O. Gregoriou1, A. Gargaropoulos1, A. Dalamaga1, T. Mantzavinos1
12nd Department of Obstetrics and Gynaecology, Areteion Hospital, University of Athens, Athens, Greece

Tóm tắt

AbstractOBJECTIVES: To examine the immunological profiles by antiphospholipid antibodies IgG, IgM, IgA immunoglobulins ACA, as well as C3, C4 complement component levels. METHODS: A group of 44 women with a history of three or more consecutive pregnancy losses was compared with 34 normal women. RESULTS: Our results showed lower levels of IgG immunoglobulins for the patient group (P < 0.001) while the C3, C4 complement component levels remained unaltered. Anticardiolipin antibodies were positive in ten patients for IgG or IgM isotypes or for both presenting a prevalence of 22.7% while none of the control subjects had ACA positive titers. The lupus anticoagulant was not detected in either group. Ten patients (22.7%) presented positive autoantibody tests as compared with only 3 (8.8%) of the control group. No statistical differences were found between the two groups when the frequency of each autoantibody's positive tests were examined separately. CONCLUSIONS: An inconsistent immune derangement seems to be present in recurrent aborters with the presence of anticardiolipin antibodies as the stronger representative marker of immune alteration.

Tài liệu tham khảo

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Thông tin xuất bản

International Journal of Gynecology & Obstetrics

Tập 45

221-226

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