Imaging-Based Assessment of Steatosis, Inflammation and Fibrosis in NAFLD
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• Middleton MS, Heba ER, Hooker CA, Bashir MR, Fowler KJ, Sandrasegaran K, et al. Agreement between magnetic resonance imaging proton density fat fraction measurements and pathologist-assigned steatosis grades of liver biopsies from adults with nonalcoholic steatohepatitis. Gastroenterology. 2017.Paper uses data from the FLINT study and shows the utility of MRI-PDFF for longitudinal assessment of steatosis.
Mansour D, McPherson S. Editorial: further evidence for the use of advanced magnetic resonance imaging techniques to monitor NAFLD. Aliment Pharmacol Ther. 2017;45(9):1269–70.
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• Koehler EM, Plompen EP, Schouten JN, Hansen BE, Darwish Murad S, Taimr P, et al. Presence of diabetes mellitus and steatosis is associated with liver stiffness in a general population: the Rotterdam study. Hepatology. 2016;63(1):138–47. Demonstrates the clinical utility of TE in a population-based setting.
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• Petta S, Maida M, Macaluso FS, Di Marco V, Camma C, Cabibi D, et al. The severity of steatosis influences liver stiffness measurement in patients with nonalcoholic fatty liver disease. Hepatology. 2015;62(4):1101–10. Excellent study demonstrating that inaccurate TE measurements may be mitigated by CAP.
Petta S, Wong VW, Camma C, Hiriart JB, Wong GL, Marra F, et al. Improved noninvasive prediction of liver fibrosis by liver stiffness measurement in patients with nonalcoholic fatty liver disease accounting for controlled attenuation parameter values. Hepatology. 2017;65(4):1145–55.
•• Cassinotto C, Boursier J, de Ledinghen V, Lebigot J, Lapuyade B, Cales P, et al. Liver stiffness in nonalcoholic fatty liver disease: a comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy. Hepatology. 2016;63(6):1817–27. Landmark study comparing the clinical utility of several liver stiffness modalities for the detection of fibrosis in NAFLD patients.
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• de Ledinghen V, Wong VW, Vergniol J, Wong GL, Foucher J, Chu SH, et al. Diagnosis of liver fibrosis and cirrhosis using liver stiffness measurement: comparison between M and XL probe of FibroScan(R). J Hepatol. 2012;56(4):833–9. Well conducted study showing unreliable results using the M probe are mitigated by use of XL probe.
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