Identification of a novel redox switch between metabolism and cardiac function using HyPer power

Amponsah-Offeh M, Diaba-Nuhoho P, Speier S, Morawietz H (2023) Oxidative stress, antioxidants and hypertension. Antioxidants (Basel) 12:281. https://doi.org/10.3390/antiox12020281 Brandes RP, Rezende F, Schroder K (2018) Redox regulation beyond ROS: why ROS should not be measured as often. Circ Res 123:326–328. https://doi.org/10.1161/CIRCRESAHA.118.313146 Heusch G (2021) Myocardial stunning and hibernation revisited. Nat Rev Cardiol 18:522–536. https://doi.org/10.1038/s41569-021-00506-7 Langbein H, Brunssen C, Hofmann A, Cimalla P, Brux M, Bornstein SR, Deussen A, Koch E, Morawietz H (2016) NADPH oxidase 4 protects against development of endothelial dysfunction and atherosclerosis in LDL receptor deficient mice. Eur Heart J 37:1753–1761. https://doi.org/10.1093/eurheartj/ehv564 Morawietz H (2018) Cardiovascular protection by Nox4. Cardiovasc Res 114:353–355. https://doi.org/10.1093/cvr/cvx252 Nanadikar MS, Vergel Leon AM, Guo J, van Belle GJ, Jatho A, Philip ES, Brandner AF, Bockmann RA, Shi R, Zieseniss A, Siemssen CM, Dettmer K, Brodesser S, Schmidtendorf M, Lee J, Wu H, Furdui CM, Brandenburg S, Burgoyne JR, Bogeski I, Riemer J, Chowdhury A, Rehling P, Bruegmann T, Belousov VV, Katschinski DM (2023) IDH3gamma functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart. Nat Commun 14:2123. https://doi.org/10.1038/s41467-023-37744-x Schroder K (2020) NADPH oxidases: current aspects and tools. Redox Biol 34:101512. https://doi.org/10.1016/j.redox.2020.101512 Schurmann C, Rezende F, Kruse C, Yasar Y, Lowe O, Fork C, van de Sluis B, Bremer R, Weissmann N, Shah AM, Jo H, Brandes RP, Schroder K (2015) The NADPH oxidase Nox4 has anti-atherosclerotic functions. Eur Heart J 36:3447–3456. https://doi.org/10.1093/eurheartj/ehv460 Swain L, Nanadikar MS, Borowik S, Zieseniss A, Katschinski DM (2018) Transgenic organisms meet redox bioimaging: one step closer to physiology. Antioxid Redox Signal 29:603–612. https://doi.org/10.1089/ars.2017.7469 Zhao QD, Viswanadhapalli S, Williams P, Shi Q, Tan C, Yi X, Bhandari B, Abboud HE (2015) NADPH oxidase 4 induces cardiac fibrosis and hypertrophy through activating Akt/mTOR and NFkappaB signaling pathways. Circulation 131:643–655. https://doi.org/10.1161/CIRCULATIONAHA.114.011079