Identification of Herpesvirus-Like DNA Sequences in AIDS-Sssociated Kaposi's Sarcoma

American Association for the Advancement of Science (AAAS) - Tập 266 Số 5192 - Trang 1865-1869 - 1994
Yuan Chang1, Ethel Cesarman1, Melissa S. Pessin1, Frank Lee2, Janice Culpepper2, Daniel M. Knowles1, Patrick S. Moore3
1Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
2DNAX Research Institute, Department of Molecular Biology, Palo Alto, CA 94304-1104, USA.
3Disease Intervention Commission, New York City Department of Health, New York, NY 10013 and Division of Epidemiology, School of Public Health, Columbia University, New York, NY 10013, USA.

Tóm tắt

Representational difference analysis was used to isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus.

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American Association for the Advancement of Science (AAAS)

Tập 266 Số 5192

1865-1869

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