INSECT P450 ENZYMES

Annual Review of Entomology - Tập 44 Số 1 - Trang 507-533 - 1999
René Feyereisen1
1Department of Entomology, University of Arizona, Tucson, Arizona 85721

Tóm tắt

▪ Abstract  The P450 enzymes (mixed function oxidases, cytochrome P450 monooxygenases), a diverse class of enzymes found in virtually all insect tissues, fulfill many important tasks, from the synthesis and degradation of ecdysteroids and juvenile hormones to the metabolism of foreign chemicals of natural or synthetic origin. This diversity in function is achieved by a diversity in structure, as insect genomes probably carry about 100 P450 genes, sometimes arranged in clusters, and each coding for a different P450 enzyme. Both microsomal and mitochondrial P450s are present in insects and are best studied by heterologous expression of their cDNA and reconstitution of purified enzymes. P450 genes are under complex regulation, with induction playing a central role in the adaptation to plant chemicals and regulatory mutations playing a central role in insecticide resistance. Polymorphisms in induction or constitutive expression allow insects to scan their P450 gene repertoire for the appropriate response to chemical insults, and these evolutionary pressures in turn maintain P450 diversity.

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Tài liệu tham khảo

Agosin M. 1985. Role of microsomal oxidations in insecticide degradation. See Ref.87A, 12:647–712

10.1002/arch.940060206

Amichot M, Brun A, Cuany A, Helvig C, Salaun JP, et al. 1994. Expression study of CYP genes inDrosophilastrains resistant or sensitive to insecticides. See Ref.91A, pp. 689–92

10.1016/0965-1748(95)00010-S

10.1021/bi00174a025

10.1021/tx9601162

10.1016/0048-3575(86)90015-5

10.1016/S0303-7207(97)00093-2

Berenbaum MR, Cohen MB, Schuler MA. 1990. Cytochrome P450 in plant-insect interactions: inductions and deductions. See Ref.65A, pp. 257–62

10.1086/285907

10.1098/rstb.1998.0321

10.1080/15287399309531712

10.2307/1941237

10.1093/aesa/53.3.360

10.1006/pest.1994.1064

10.1038/268660a0

10.1126/science.986685

10.1073/pnas.88.10.4558

10.3109/03602537908993900

10.1126/science.196.4296.1349

10.1016/S0965-1748(96)00036-7

10.1021/bk-1992-0505.ch003

10.1016/0965-1748(94)90034-5

10.1089/dna.1995.14.73

10.1016/0378-1119(94)90304-2

10.1073/pnas.89.22.10920

10.1096/fasebj.10.4.8647341

10.1016/0048-3575(90)90136-P

10.1016/S0965-1748(97)00035-0

10.1073/pnas.94.20.10797

10.1006/bbrc.1997.7739

10.1006/abio.1995.1382

Deleted in proof

10.1089/dna.1997.16.1345

10.1007/s004380050169

Ellis-Pratt G. 1983.The mode of action of pro-allatocidins.InNatural Products for Innovative Pest Management, ed. D Whitehead, WS Bowers, pp. 323–55. Oxford, UK: Pergamon

10.1096/fasebj.10.2.8641552

10.1002/arch.940290303

Feyereisen R, 1977, CR Acad. Sci. Paris, 284, 1831

10.1016/0048-3575(83)90054-8

10.1111/j.1432-1033.1978.tb12420.x

10.1016/0303-7207(80)90079-9

10.1016/0020-1790(85)90104-0

10.1021/bk-1985-0276.ch018

10.1016/0022-1910(81)90087-1

Feyereisen R, Koener JF, Carino FA, Daggett AS. 1990. Biochemistry and molecular biology of insect cytochrome P450. See Ref.65A, pp. 263–72

10.1073/pnas.86.5.1465

10.1016/0020-1790(84)90079-9

10.1111/j.1432-1033.1981.tb06391.x

10.1007/978-1-4899-1751-5_2

10.1073/pnas.89.24.11998

10.1089/dna.1994.13.663

10.1016/0006-2952(94)90317-4

10.1089/dna.1992.11.397

10.1101/SQB.1987.052.01.098

10.1097/00008571-199302000-00006

10.1016/0168-9525(90)90174-5

Gotoh O. 1993. Evolution and differentiation of P-450 genes. See Ref.112, pp. 255–72

10.1111/j.1365-2311.1984.tb00695.x

10.1002/em.2860060206

10.1016/0965-1748(93)90077-6

10.1016/0048-3575(86)90095-7

10.1007/BF00993727

10.1074/jbc.271.43.26637

10.1006/abbi.1998.0901

10.1007/978-1-4899-3668-4

10.1016/0009-2797(85)90004-3

10.1016/0024-3205(75)90479-8

10.1016/0048-3575(78)90062-7

Hammock BD, 1981, Progr. Pestic. Biochem., 1, 1

10.1016/0024-3205(83)90395-8

10.1039/c39930001497

Hodgson E. 1985. Microsomal mono-oxygenases. See Ref.87A, 11:225–321

10.1139/g88-136

10.1016/S0378-1119(96)00851-7

10.1016/S0965-1748(97)00009-X

10.1111/j.1365-2583.1995.tb00020.x

10.1073/pnas.93.22.12200

10.1016/0965-1748(94)00038-J

10.1007/BF01013904

10.1128/MCB.13.11.7101

Nelson DR. http://drnelson.utmem.edu/nelsonhomepage.html

Feyereisen R. http://ag.arizona.edu/p450/insectp450.html

10.1042/bj1680513

10.1016/0020-1790(86)90074-0

10.1016/0022-4731(88)90330-5

10.1111/j.1432-1033.1997.00707.x

Keeley LL, Bradfield JY, Sowa SM, Lee YH, Lu KH. 1994.Physiological actions of hypertrehalosemic hormones in cockroaches.InPerspectives in Comparative Endocrinology, ed. KG Davey, pp. 475–85. Ottawa, Can: Natl. Sci. Eng. Res. Council

Kerkut GA, 1985, Comprehensive Insect Physiology, Biochemistry, and Physiology.

10.1006/pest.1994.1031

10.1016/0965-1748(93)90051-S

10.1126/science.172.3983.579

10.1002/arch.940010106

Lechner MC, 1994, Cytochrome P450. 8th Int. Conf.

10.1016/0048-3575(88)90105-8

Lindroth RL. 1991. Differential toxicity of plant allelochemicals to insects: roles of enzymatic detoxication systems. InInsect-Plant Interactions, Vol. 3, ed. EA Bernays. Boca Raton, FL: CRC

10.1007/BF00553609

10.1006/abbi.1994.1175

10.1016/S0378-1119(96)00446-5

Mansuy D, Renaud JP. 1995. Heme-thiolate proteins different from cytochrome P450 catalyzing monooxygenations. See Ref.114, pp. 537–74

10.1007/BF02099942

10.1515/bchm2.1978.359.2.1247

Megias A, 1984, Comp. Biochem. Physiol., 77, 679, 10.1016/0300-9629(84)90184-1

10.1016/S0965-1748(98)00131-3

10.1021/bi970026b

Nahri LO, 1986, J. Biol. Chem., 261, 7160, 10.1016/S0021-9258(17)38369-2

10.1093/oxfordjournals.jbchem.a021260

10.1006/pest.1994.1056

10.1089/dna.1987.6.1

Nebert DW, Feyereisen R. 1994. Evolutionary argument for a connection between drug metabolism and signal transduction. See Ref.91A, pp. 3–13

10.1097/00008571-199602000-00002

Nelson DR, 1987, Mol. Biol. Evol., 4, 572

Neuman R, 1985, Insecticides, 2, 35

10.1073/pnas.94.14.7464

Omura T, 1993, Cytochrome P-450.

Omura T, 1964, J. Biol. Chem., 239, 2370, 10.1016/S0021-9258(20)82244-3

10.1126/science.132.3422.298

10.1007/978-1-4757-2391-5

10.1016/0048-3575(91)90085-Z

10.1016/S0965-1748(97)00025-8

10.1016/0048-3575(84)90089-0

Deleted in proof

10.1093/nar/22.15.3210

10.1016/0048-3575(90)90094-I

Prestwich GD. 1990.Proinsecticides: metabolically activated toxicants.InSafer Insecticides, Development and Use, ed. E Hodgson, RJ Kuhr, pp. 281–335. New York: Dekker

10.1002/(SICI)1520-6327(1997)34:1<99::AID-ARCH8>3.0.CO;2-R

10.1021/bi00049a038

10.1073/pnas.91.21.10000

Rees HH, 1995, Eur. J. Entomol., 92, 9

10.1073/pnas.86.4.1421

10.1016/0048-3575(88)90123-X

10.1111/j.1365-2311.1985.tb00744.x

10.1006/pest.1995.1018

10.1016/S0965-1748(97)00036-2

10.1002/(SICI)1098-2280(1996)27:1<46::AID-EM7>3.3.CO;2-Z

10.1007/978-3-642-77763-9

10.1006/bbrc.1994.2828

10.1002/(SICI)1520-6327(1996)31:3<313::AID-ARCH6>3.0.CO;2-Y

10.1007/BF00222792

10.1007/BF00980591

10.1016/S0076-6879(96)72036-0

10.1006/abbi.1995.1362

10.1016/0965-1748(94)90112-0

10.1006/bbrc.1997.6273

Deleted in proof

10.1016/0048-3575(89)90008-4

10.1073/pnas.95.22.12884

10.1093/oxfordjournals.molbev.a025633

10.1006/pest.1996.0029

10.1111/j.1365-2583.1995.tb00018.x

10.1016/0965-1748(94)00066-Q

10.1002/ps.2780430103

10.1007/BF00344520

Von Wachenfeldt C, Johnson EF. 1995. Structures of eukaryotic cytochrome P450 enzymes. See Ref.114, pp. 183–223

10.1016/0048-3575(88)90036-3

10.1073/pnas.89.11.4855

10.1016/0048-3575(90)90046-5

10.1016/0048-3575(79)90028-2

10.3109/03602537208993912

10.1074/jbc.272.13.8427

10.1016/0965-1748(95)00033-R

10.1007/978-1-4613-1865-1_4

10.1016/0048-3575(91)90216-9

10.1016/0048-3575(92)90011-N

10.1016/0022-1910(74)90097-3

10.1016/0305-0491(95)02028-4

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Annual Review of Entomology

Tập 44 Số 1

507-533

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