IL15 Tăng Cường Hoạt Động Chống Khối U Của Tế Bào CAR-T Bằng Cách Giảm Hoạt Động mTORC1 Và Bảo Tồn Đặc Điểm Nhớ Tế Bào Gốc Của Chúng
Tóm tắt
Từ khóa
Tài liệu tham khảo
Kawalekar, 2016, Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells, Immunity, 44, 712, 10.1016/j.immuni.2016.02.023
Xu, 2014, Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15, Blood, 123, 3750, 10.1182/blood-2014-01-552174
Zhang, 2007, 4–1BB is superior to CD28 costimulation for generating CD8+ cytotoxic lymphocytes for adoptive immunotherapy, J Immunol, 179, 4910, 10.4049/jimmunol.179.7.4910
Song, 2011, In vivo persistence, tumor localization, and antitumor activity of CAR-engineered T cells is enhanced by costimulatory signaling through CD137 (4-1BB), Cancer Res, 71, 4617, 10.1158/0008-5472.CAN-11-0422
Wang, 2018, Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity, JCI Insight, 3, 10.1172/jci.insight.99048
Rosenberg, 2014, IL-2: the first effective immunotherapy for human cancer., J Immunol, 192, 5451, 10.4049/jimmunol.1490019
Gattinoni, 2009, Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells, Nat Med, 15, 808, 10.1038/nm.1982
Wang, 2011, A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells, Blood, 118, 1255, 10.1182/blood-2011-02-337360
Berger, 2008, Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates, J Clin Invest, 118, 294, 10.1172/JCI32103
Gattinoni, 2005, Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells, J Clin Invest, 115, 1616, 10.1172/JCI24480
Gattinoni, 2011, A human memory T cell subset with stem cell-like properties, Nat Med, 17, 1290, 10.1038/nm.2446
Rochman, 2009, New insights into the regulation of T cells by gamma(c) family cytokines, Nat Rev Immunol, 9, 480, 10.1038/nri2580
Cieri, 2013, IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors, Blood, 121, 573, 10.1182/blood-2012-05-431718
Santegoets, 2013, IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells, J of Transl Med, 11, 37, 10.1186/1479-5876-11-37
Singh, 2011, Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies, Cancer Res, 71, 3516, 10.1158/0008-5472.CAN-10-3843
Sukumar, 2013, Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function, J Clin Invest, 123, 4479, 10.1172/JCI69589
Pearce, 2009, Enhancing CD8 T-cell memory by modulating fatty acid metabolism, Nature, 460, 103, 10.1038/nature08097
Sinclair, 2013, Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation, Nat Immunol, 14, 500, 10.1038/ni.2556
Li, 2011, A central role for mTOR kinase in homeostatic proliferation induced CD8+ T cell memory and tumor immunity, Immunity, 34, 541, 10.1016/j.immuni.2011.04.006
Araki, 2010, The role of mTOR in memory CD8 T-cell differentiation, Immunol Rev, 235, 234, 10.1111/j.0105-2896.2010.00898.x
Araki, 2009, mTOR regulates memory CD8 T-cell differentiation, Nature, 460, 108, 10.1038/nature08155
Brown, 2018, Optimization of IL13Ralpha2-targeted chimeric antigen receptor T cells for improved anti-tumor efficacy against glioblastoma, Mol Ther, 26, 31, 10.1016/j.ymthe.2017.10.002
Wang, 2016, Phase 1 studies of central memory-derived CD19 CAR T-cell therapy following autologous HSCT in patients with B-cell NHL, Blood, 127, 2980, 10.1182/blood-2015-12-686725
Robinson, 2010, edgeR: a Bioconductor package for differential expression analysis of digital gene expression data, Bioinformatics, 26, 139, 10.1093/bioinformatics/btp616
Boyman, 2012, The role of interleukin-2 during homeostasis and activation of the immune system, Nat Rev Immunol, 12, 180, 10.1038/nri3156
Zhang, 1998, Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15, Immunity, 8, 591, 10.1016/S1074-7613(00)80564-6
Sandau, 2010, IL-15 regulates both quantitative and qualitative features of the memory CD8 T cell pool, J Immunol, 184, 35, 10.4049/jimmunol.0803355
Saligrama, 2014, IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3, Cell Death Differ, 21, 904, 10.1038/cdd.2014.10
Klebanoff, 2004, IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells, Proc Natl Acad Sci USA, 101, 1969, 10.1073/pnas.0307298101
Jonnalagadda, 2015, Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy, Mol Ther, 23, 757, 10.1038/mt.2014.208
Brown, 2016, Regression of glioblastoma after chimeric antigen receptor T-cell therapy, N Engl J Med, 375, 2561, 10.1056/NEJMoa1610497
Kaartinen, 2017, Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion, Cytotherapy, 19, 1130, 10.1016/j.jcyt.2017.06.003
Li, 2001, IL-15 and IL-2: a matter of life and death for T cells in vivo, Nat Med, 7, 114, 10.1038/83253
Marks-Konczalik, 2000, IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice, Proc Natl Acad Sci USA, 97, 11445, 10.1073/pnas.200363097
Kaur, 2011, T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules, Cytokine, 55, 307, 10.1016/j.cyto.2011.04.014
Long, 2015, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors, Nat Med, 21, 581, 10.1038/nm.3838
Crompton, 2015, Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics, Cancer Res, 75, 296, 10.1158/0008-5472.CAN-14-2277
Duvel, 2010, Activation of a metabolic gene regulatory network downstream of mTOR complex 1, Mol Cell, 39, 171, 10.1016/j.molcel.2010.06.022
Man, 2015, Synchronizing transcriptional control of T cell metabolism and function, Nat Rev Immunol, 15, 574, 10.1038/nri3874
Sukumar, 2016, Mitochondrial membrane potential identifies cells with enhanced stemness for cellular therapy, Cell Metab, 23, 63, 10.1016/j.cmet.2015.11.002
Zeng, 2005, Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function, J Exp Med, 201, 139, 10.1084/jem.20041057
Hurton, 2016, Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells, Proc Natl Acad Sci USA, 113, E7788, 10.1073/pnas.1610544113
Krenciute, 2017, Transgenic expression of IL15 improves antiglioma activity of IL13Ralpha2-CAR T cells but results in antigen loss variants, Cancer Immunol Res, 5, 571, 10.1158/2326-6066.CIR-16-0376
Chang, 2016, Emerging concepts of T cell metabolism as a target of immunotherapy, Nat Immunol, 17, 364, 10.1038/ni.3415
Teague, 2006, Interleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumors, Nat Med, 12, 335, 10.1038/nm1359
Purton, 2007, Antiviral CD4+ memory T cells are IL-15 dependent, J Exp Med, 204, 951, 10.1084/jem.20061805
Xu, 2011, IL-15 and dendritic cells induce proliferation of CD4+CD25+ regulatory T cells from peripheral blood, Immunol Lett, 140, 59, 10.1016/j.imlet.2011.06.005