IDENTIFICATION AND CHARACTERIZATION OF THE HUMAN HEPATIC ANDROGEN RECEPTOR

Clinical Endocrinology - Tập 23 Số 5 - Trang 495-502 - 1985
P. Bannister1, Peter J. Sheridan1, M S Losowsky1
1Department of Medicine, St. James's University Hospital, Leeds LS9 7TF UK

Tóm tắt

SUMMARYHuman liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) present in cytosol alone and a low molecular weight component (mol wt. 75 000) present in cytosol and nucleosol. Human liver contains the classical androgen receptor.

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