ICU survival and need of renal replacement therapy with respect to AKI duration in critically ill patients

Annals of Intensive Care - Tập 8 Số 1 - Trang 1-11 - 2018
Truche, A. S.1,2,3, Ragey, S. Perinel4, Souweine, B.5, Bailly, S.1,2, Zafrani, L.6,7, Bouadma, L.8, Clec’h, C.9,10, Garrouste-Orgeas, M.11,12, Lacave, G.13, Schwebel, C.2, Guebre-Egziabher, F.3, Adrie, C.14, Dumenil, A. S.15, Zaoui, Ph.3, Argaud, L.16, Jamali, S.17, Goldran Toledano, D.18, Marcotte, G.19, Timsit, J. F.1,8, Darmon, M.6,7,20
1UMR 1137 - IAME Team 5 – DeSCID : Decision SCiences in Infectious Diseases, Control and Care, Inserm/Paris Diderot University, Sorbonne Paris Cité, Paris, France
2Medical Intensive Care Unit, Grenoble University Hospital, La Tronche, France
3Nephrology Dialysis Renal Transplantation, Grenoble University Hospital, La Tronche, France
4Medical Intensive Care Unit, Croix Rousse Hospital, Lyon University Hospital, Lyon, France
5Medical Intensive Care Unit, Gabriel Montpied University Hospital, Clermont-Ferrand, France
6Medical Intensive Care Unit, AP-HP, Saint Louis Hospital, Paris, France
7Medicine University, Paris 7 University, Paris, France
8Medical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat Hospital, Paris Diderot University, Paris, France
9Intensive Care Unit, AP-HP, Avicenne Hospital, Paris, France
10Medicine University, Paris 13 University, Bobigny, France
11Intensive Care Unit, Saint Joseph Hospital Network, Paris, France
12Medicine University, Paris Descartes University, Sorbonne Cite, Paris, France
13Medical Intensive Care Unit, André Mignot Hospital, Versailles, France
14Physiology Department, Cochin University Hospital, Assistance Publique, Hôpitaux de Paris (AP-HP), Paris Descartes University des, Sorbonne Cite, Paris, France
15Medical-Surgical Intensive Care Unit, AP-HP, Antoine Béclère University Hospital, Clamart, France
16Medical Intensive Care Unit, Edouard Herriot University Hospital, Lyon, France
17Critical Care Medicine Unit, Dourdan Hospital, Dourdan, France
18Intensive Care Unit, Gonesse Hospital, Gonesse, France
19Surgical ICU, Edouard Herriot University Hospital, Lyon, France
20ECSTRA team, Biostatistics and clinical epidemiology, UMR 1153 (center of epidemiology and biostatistics Sorbonne Paris Cité, CRESS), INSERM, Paris, France

Tóm tắt

Transient and persistent acute kidney injury (AKI) could share similar physiopathological mechanisms. The objective of our study was to assess prognostic impact of AKI duration on ICU mortality. Retrospective analysis of a prospective database via cause-specific model, with 28-day ICU mortality as primary end point, considering discharge alive as a competing event and taking into account time-dependent nature of renal recovery. Renal recovery was defined as a decrease of at least one KDIGO class compared to the previous day. 23 French ICUs. Patients of a French multicentric observational cohort were included if they suffered from AKI at ICU admission between 1996 and 2015. None. A total of 5242 patients were included. Initial severity according to KDIGO creatinine definition was AKI stage 1 for 2458 patients (46.89%), AKI stage 2 for 1181 (22.53%) and AKI stage 3 for 1603 (30.58%). Crude 28-day ICU mortality according to AKI severity was 22.74% (n = 559), 27.69% (n = 327) and 26.26% (n = 421), respectively. Renal recovery was experienced by 3085 patients (58.85%), and its rate was significantly different between AKI severity stages (P < 0.01). Twenty-eight-day ICU mortality was independently lower in patients experiencing renal recovery [CSHR 0.54 (95% CI 0.46–0.63), P < 0.01]. Lastly, RRT requirement was strongly associated with persistent AKI whichever threshold was chosen between day 2 and 7 to delineate transient from persistent AKI. Short-term renal recovery, according to several definitions, was independently associated with higher mortality and RRT requirement. Moreover, distinction between transient and persistent AKI is consequently a clinically relevant surrogate outcome variable for diagnostic testing in critically ill patients.

Tài liệu tham khảo

citation_journal_title=Intensive Care Med; citation_title=Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study; citation_author=EAJ Hoste, SM Bagshaw, R Bellomo, CM Cely, R Colman, DN Cruz; citation_volume=41; citation_publication_date=2015; citation_pages=1411-1423; citation_doi=10.1007/s00134-015-3934-7; citation_id=CR1 citation_journal_title=Crit Care; citation_title=Three-year risk of cardiovascular disease among intensive care patients with acute kidney injury: a population-based cohort study; citation_author=H Gammelager, CF Christiansen, MB Johansen, E Tønnesen, B Jespersen, HT Sørensen; citation_volume=18; citation_publication_date=2014; citation_pages=492; citation_doi=10.1186/s13054-014-0492-2; citation_id=CR2 citation_journal_title=Crit Care; citation_title=One-year mortality among Danish intensive care patients with acute kidney injury: a cohort study; citation_author=H Gammelager, CF Christiansen, MB Johansen, E Tønnesen, B Jespersen, HT Sørensen; citation_volume=16; citation_publication_date=2012; citation_pages=R124; citation_doi=10.1186/cc11420; citation_id=CR3 citation_journal_title=Crit Care; citation_title=Evolution of chronic renal impairment and long-term mortality after de novo acute kidney injury in the critically ill; a Swedish multi-centre cohort study; citation_author=C Rimes-Stigare, P Frumento, M Bottai, J Mårtensson, C-R Martling, SM Walther; citation_volume=19; citation_publication_date=2015; citation_pages=221; citation_doi=10.1186/s13054-015-0920-y; citation_id=CR4 citation_journal_title=Crit Care; citation_title=Acute Dialysis Quality Initiative workgroup. Acute renal failure—definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group; citation_author=R Bellomo, C Ronco, JA Kellum, RL Mehta, P Palevsky; citation_volume=8; citation_publication_date=2004; citation_pages=R204-R212; citation_doi=10.1186/cc2872; citation_id=CR5 citation_journal_title=Crit Care; citation_title=Acute kidney injury network: report of an initiative to improve outcomes in acute kidney injury; citation_author=RL Mehta, JA Kellum, SV Shah, BA Molitoris, C Ronco, DG Warnock; citation_volume=11; citation_publication_date=2007; citation_pages=R31; citation_doi=10.1186/cc5713; citation_id=CR6 citation_journal_title=Crit Care; citation_title=Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1); citation_author=JA Kellum, N Lameire; citation_volume=17; citation_publication_date=2013; citation_pages=204; citation_doi=10.1186/cc11454; citation_id=CR7 citation_journal_title=Nat Rev Nephrol.; citation_title=Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup; citation_author=LS Chawla, R Bellomo, A Bihorac, SL Goldstein, ED Siew, SM Bagshaw; citation_volume=13; citation_publication_date=2017; citation_pages=241-257; citation_doi=10.1038/nrneph.2017.2; citation_id=CR8 citation_journal_title=Nat Rev Nephrol.; citation_title=Acute kidney injury: defining prerenal azotemia in clinical practice and research; citation_author=CR Parikh, SG Coca; citation_volume=6; citation_publication_date=2010; citation_pages=641-642; citation_doi=10.1038/nrneph.2010.128; citation_id=CR9 citation_journal_title=Crit Care Med; citation_title=Renal histopathology during experimental septic acute kidney injury and recovery; citation_author=C Langenberg, G Gobe, S Hood, CN May, R Bellomo; citation_volume=42; citation_publication_date=2014; citation_pages=e58-e67; citation_doi=10.1097/CCM.0b013e3182a639da; citation_id=CR10 citation_journal_title=Crit Care; citation_title=Urinalysis and pre-renal acute kidney injury: time to move on; citation_author=AG Schneider, R Bellomo; citation_volume=17; citation_publication_date=2013; citation_pages=141; citation_doi=10.1186/cc12676; citation_id=CR11 citation_journal_title=Am J Respir Crit Care Med; citation_title=Mechanisms of cardiac and renal dysfunction in patients dying of sepsis; citation_author=O Takasu, JP Gaut, E Watanabe, K To, RE Fagley, B Sato; citation_volume=187; citation_publication_date=2013; citation_pages=509-517; citation_doi=10.1164/rccm.201211-1983OC; citation_id=CR12 citation_journal_title=Crit Care; citation_title=Diagnostic performance of fractional excretion of urea in the evaluation of critically ill patients with acute kidney injury: a multicenter cohort study; citation_author=M Darmon, F Vincent, J Dellamonica, F Schortgen, F Gonzalez, V Das; citation_volume=15; citation_publication_date=2011; citation_pages=R178; citation_doi=10.1186/cc10327; citation_id=CR13 citation_journal_title=Crit Care Med; citation_title=Transient and persistent acute kidney injury and the risk of hospital mortality in critically ill patients: results of a multicenter cohort study; citation_author=S Perinel, F Vincent, A Lautrette, J Dellamonica, C Mariat, F Zeni; citation_volume=43; citation_publication_date=2015; citation_pages=e269-e275; citation_doi=10.1097/CCM.0000000000001077; citation_id=CR14 citation_journal_title=Crit Care Med; citation_title=Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysis; citation_author=C Clec’h, C Alberti, F Vincent, M Garrouste-Orgeas, A Lassence, D Toledano; citation_volume=35; citation_publication_date=2007; citation_pages=132-138; citation_doi=10.1097/01.CCM.0000251134.96055.A6; citation_id=CR15 citation_journal_title=JAMA; citation_title=A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study; citation_author=JR Gall, S Lemeshow, F Saulnier; citation_volume=270; citation_publication_date=1993; citation_pages=2957-2963; citation_doi=10.1001/jama.1993.03510240069035; citation_id=CR16 citation_journal_title=Intensive Care Med; citation_title=The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine; citation_author=JL Vincent, R Moreno, J Takala, S Willatts, A Mendonça, H Bruining; citation_volume=22; citation_publication_date=1996; citation_pages=707-710; citation_doi=10.1007/BF01709751; citation_id=CR17 citation_journal_title=JAMA; citation_title=The third international consensus definitions for sepsis and septic shock (Sepsis-3); citation_author=M Singer, CS Deutschman, CW Seymour, M Shankar-Hari, D Annane, M Bauer; citation_volume=315; citation_publication_date=2016; citation_pages=801-810; citation_doi=10.1001/jama.2016.0287; citation_id=CR18 citation_journal_title=Kidney Int; citation_title=Clinical practice guideline for the evaluation and management of chronic kidney disease; citation_author=; citation_volume=2013; citation_issue=3; citation_publication_date=2012; citation_pages=1-150; citation_id=CR19 citation_journal_title=Stat Med; citation_title=Competing risks analysis of patients with osteosarcoma: a comparison of four different approaches; citation_author=BC Tai, D Machin, I White, V Gebski; citation_volume=20; citation_publication_date=2001; citation_pages=661-684; citation_doi=10.1002/sim.711; citation_id=CR20 citation_journal_title=Crit Care; citation_title=Risk factors for the development of nosocomial pneumonia and mortality on intensive care units: application of competing risks models; citation_author=M Wolkewitz, RP Vonberg, H Grundmann, J Beyersmann, P Gastmeier, S Bärwolff; citation_volume=12; citation_publication_date=2008; citation_pages=R44; citation_doi=10.1186/cc6852; citation_id=CR21 citation_journal_title=Intensive Care Med; citation_title=Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study; citation_author=S Nisula, K-M Kaukonen, ST Vaara, A-M Korhonen, M Poukkanen, S Karlsson; citation_volume=39; citation_publication_date=2013; citation_pages=420-428; citation_doi=10.1007/s00134-012-2796-5; citation_id=CR22 citation_journal_title=Chest; citation_title=Severity of acute kidney injury and 2-year outcomes in critically ill patients; citation_author=L Fuchs, J Lee, V Novack, Y Baumfeld, D Scott, L Celi; citation_volume=144; citation_publication_date=2013; citation_pages=866-875; citation_doi=10.1378/chest.12-2967; citation_id=CR23 citation_journal_title=Crit Care; citation_title=Multiple-center evaluation of mortality associated with acute kidney injury in critically ill patients: a competing risks analysis; citation_author=C Clec’h, F Gonzalez, A Lautrette, M Nguile-Makao, M Garrouste-Orgeas, S Jamali; citation_volume=15; citation_publication_date=2011; citation_pages=R128; citation_doi=10.1186/cc10241; citation_id=CR24 citation_journal_title=Crit Care Med; citation_title=Acute kidney injury in the intensive care unit according to RIFLE; citation_author=M Ostermann, RWS Chang; citation_volume=35; citation_publication_date=2007; citation_pages=1837-1843; citation_doi=10.1097/01.CCM.0000277041.13090.0A; citation_id=CR25 citation_journal_title=Kidney Int; citation_title=Some biomarkers of acute kidney injury are increased in pre-renal acute injury; citation_author=M Nejat, JW Pickering, P Devarajan, JV Bonventre, CL Edelstein, RJ Walker; citation_volume=81; citation_publication_date=2012; citation_pages=1254-1262; citation_doi=10.1038/ki.2012.23; citation_id=CR26 citation_journal_title=J Am Soc Nephrol; citation_title=Classifying AKI by urine output versus serum creatinine level; citation_author=JA Kellum, FE Sileanu, R Murugan, N Lucko, AD Shaw, G Clermont; citation_volume=26; citation_publication_date=2015; citation_pages=2231-2238; citation_doi=10.1681/ASN.2014070724; citation_id=CR27 citation_journal_title=Crit Care; citation_title=Diagnostic accuracy of early urinary index changes in differentiating transient from persistent acute kidney injury in critically ill patients: multicenter cohort study; citation_author=B Pons, A Lautrette, J Oziel, J Dellamonica, R Vermesch, E Ezingeard; citation_volume=17; citation_publication_date=2013; citation_pages=R56; citation_doi=10.1186/cc12582; citation_id=CR28 citation_journal_title=Contrib Nephrol; citation_title=Pre-renal azotemia: A flawed paradigm in critically ill septic patients?; citation_author=R Bellomo, S Bagshaw, C Langenberg, C Ronco; citation_volume=156; citation_publication_date=2007; citation_pages=1-9; citation_id=CR29 citation_journal_title=Nephrol Dial Transpl; citation_title=Transient azotaemia is associated with a high risk of death in hospitalized patients; citation_author=S Uchino, R Bellomo, SM Bagshaw, D Goldsmith; citation_volume=25; citation_publication_date=2010; citation_pages=1833-1839; citation_doi=10.1093/ndt/gfp624; citation_id=CR30 citation_journal_title=Ann Thorac Surg; citation_title=Duration of acute kidney injury impacts long-term survival after cardiac surgery; citation_author=JR Brown, RS Kramer, SG Coca, CR Parikh; citation_volume=90; citation_publication_date=2010; citation_pages=1142-1148; citation_doi=10.1016/j.athoracsur.2010.04.039; citation_id=CR31 citation_journal_title=Kidney Int; citation_title=The duration of postoperative acute kidney injury is an additional parameter predicting long-term survival in diabetic veterans; citation_author=SG Coca, JT King, RA Rosenthal, MF Perkal, CR Parikh; citation_volume=78; citation_publication_date=2010; citation_pages=926-933; citation_doi=10.1038/ki.2010.259; citation_id=CR32 citation_journal_title=Ren Fail; citation_title=The association between the duration of postoperative acute kidney injury and in-hospital mortality in critically ill patients after non-cardiac surgery: an observational cohort study; citation_author=H-C Wu, W-J Wang, Y-W Chen, H-H Chen; citation_volume=37; citation_publication_date=2015; citation_pages=985-993; citation_doi=10.3109/0886022X.2015.1044755; citation_id=CR33 citation_journal_title=J Crit Care; citation_title=Early reversible acute kidney injury is associated with improved survival in septic shock; citation_author=MM Sood, LA Shafer, J Ho, M Reslerova, G Martinka, S Keenan; citation_volume=29; citation_publication_date=2014; citation_pages=711-717; citation_doi=10.1016/j.jcrc.2014.04.003; citation_id=CR34 citation_journal_title=BMC Nephrol; citation_title=Duration of acute kidney injury and mortality in critically ill patients: a retrospective observational study; citation_author=SS Han, S Kim, SY Ahn, J Lee, DK Kim, HJ Chin; citation_volume=14; citation_publication_date=2013; citation_pages=133; citation_doi=10.1186/1471-2369-14-133; citation_id=CR35 citation_journal_title=Crit Care; citation_title=Evaluating mortality in intensive care units: contribution of competing risks analyses; citation_author=M Resche-Rigon, E Azoulay, S Chevret; citation_volume=10; citation_publication_date=2006; citation_pages=R5; citation_doi=10.1186/cc3921; citation_id=CR36 citation_journal_title=J Clin Epidemiol; citation_title=Time-dependent bias was common in survival analyses published in leading clinical journals; citation_author=C Walraven, D Davis, AJ Forster, GA Wells; citation_volume=57; citation_publication_date=2004; citation_pages=672-682; citation_doi=10.1016/j.jclinepi.2003.12.008; citation_id=CR37 citation_journal_title=Am J Respir Crit Care Med; citation_title=The effects of alternative resuscitation strategies on acute kidney injury in patients with septic shock; citation_author=JA Kellum, LS Chawla, C Keener, K Singbartl, PM Palevsky, FL Pike; citation_volume=193; citation_publication_date=2016; citation_pages=281-287; citation_doi=10.1164/rccm.201505-0995OC; citation_id=CR38 citation_journal_title=Am J Respir Crit Care Med; citation_title=Recovery after acute kidney injury; citation_author=JA Kellum, FE Sileanu, A Bihorac, EAJ Hoste, LS Chawla; citation_volume=195; citation_publication_date=2017; citation_pages=784-791; citation_doi=10.1164/rccm.201604-0799OC; citation_id=CR39 citation_journal_title=Intensive Care Med; citation_title=Defining renal recovery: pitfalls to be avoided; citation_author=F Schortgen; citation_volume=41; citation_publication_date=2015; citation_pages=1993-1995; citation_doi=10.1007/s00134-015-4033-5; citation_id=CR40 citation_journal_title=Intensive Care Med; citation_title=Recovery from AKI in the critically ill: potential confounders in the evaluation; citation_author=M Schetz, J Gunst, G Vlieger, G Berghe; citation_volume=41; citation_publication_date=2015; citation_pages=1648-1657; citation_doi=10.1007/s00134-015-3946-3; citation_id=CR41 citation_journal_title=Nephron Clin Pract; citation_title=How can we define recovery after acute kidney injury? Considerations from epidemiology and clinical trial design; citation_author=JA Kellum; citation_volume=127; citation_publication_date=2014; citation_pages=81-88; citation_doi=10.1159/000363681; citation_id=CR42 citation_journal_title=J Am Soc Nephrol; citation_title=Creatinine kinetics and the definition of acute kidney injury; citation_author=SS Waikar, JV Bonventre; citation_volume=20; citation_publication_date=2009; citation_pages=672-679; citation_doi=10.1681/ASN.2008070669; citation_id=CR43 citation_journal_title=Nephron; citation_title=Choice of reference serum creatinine in defining acute kidney injury; citation_author=ED Siew, ME Matheny; citation_volume=131; citation_publication_date=2015; citation_pages=107-112; citation_doi=10.1159/000439144; citation_id=CR44
Thông tin
Thông tin xuất bản

Annals of Intensive Care

Tập 8 Số 1

1-11

Thông tin tác giả