Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

American Association for the Advancement of Science (AAAS) - Tập 179 Số 4068 - Trang 77-79 - 1973
Paul Brazeau1, Wylie Vale1, Roger Burgus1, Nicholas Ling1, Madalyn Butcher1, Jean Rivier1, Roger Guillemin1
1Salk Institute, La Jolla, California, 92037

Tóm tắt

A peptide has been isolated from ovine hypothalamus which, at 1 × 10 -9 M , inhibits secretion in vitro of immunoreactive rat or human growth hormones and is similarly active in vivo in rats. Its structure is H-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH. The synthetic replicate is biologically active.

Từ khóa


Tài liệu tham khảo

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10.1126/science.176.4037.933