Hypolipidemic and anti‐atherogenic activities of crude polysaccharides from abalone viscera

Food Science and Nutrition - Tập 8 Số 5 - Trang 2524-2534 - 2020
Binxiong Liu1, Zhen Jia1, Changcheng Li1,2, Jinquan Chen1, Ting Fang1,2
1College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China
2Engineering Research Center of Ministry of Education: Fujian-Taiwan Featured Marine Food Processing and Nutritional Health, Fuzhou, China

Tóm tắt

AbstractThis study was performed to evaluate the hypolipidemic and anti‐atherogenic activities of the crude polysaccharides extracted from abalone viscera (AVCP). The major functional groups of purified polysaccharides were analyzed by infrared spectroscopy (IR). Male Kunming mice (SPF) were divided into six groups and were treated with normal diet or high‐fat diet with AVCP or Xuezhikang (hypotensive drug) for 5 weeks. Physicochemnical analysis of AVCP showed the presence of 60.4% polysaccharides, 17.9% protein, 6.0% fat and 10.9% moisture. The IR analysis of AVP showed the presence of functional groups of sugar moiety and sulfate groups. The results demonstrated that AVCP not only led to significant reduction of total cholesterol (TC), triglycerides (TG), low‐density lipoprotein cholesterol (LDL‐C), and increase of high‐density lipoprotein cholesterol (HDL‐C) in plasma, but also to significant increments of malondialdehyde (MDA) and superoxide dismutase (SOD) activities. However, AVCP played no role in mice weight. Furthermore, the results of the photomicrograph of liver tissue showed that AVCP reduced lipid droplets and prevented the disordered structure of the liver. The results suggested that AVCP exhibited significantly hypolipidemic and anti‐atherogenic activities.

Từ khóa


Tài liệu tham khảo

10.1016/j.ejphar.2015.05.044

10.1016/0300-483X(95)03156-A

Bai D. S., 2011, Study and comparison of two derivatization methods of polysaccharides by GC, Science and Technology of Food Industry, 32, 322

10.1016/j.foodres.2012.02.002

10.1007/BF02712151

10.1016/j.jnutbio.2011.02.001

10.1016/S1875-5364(14)60123-0

10.1016/j.foodchem.2010.12.143

10.1161/01.HYP.35.4.1009

10.1016/j.carbpol.2015.08.089

10.1016/j.foodres.2010.09.035

GB5009.3‐2016, 2016, National Food Safety Standard ‐ Determination of moisture in foods, 1

GB5009.6‐2016, 2016, National Food Safety Standard‐Determination of fat in foods, 1

Guo L. L., 2011, Antithrombotic and antifatigue activities of polysaccharide conjugates extracted from abalone gonad, Journal of Dalian Polytechnic University, 30, 250

10.3177/jnsv.39.Supplement_S43

10.1016/j.enzmictec.2004.03.001

10.1023/A:1024742907379

10.1155/2013/925804

10.1016/j.nut.2009.06.009

Liu N., 2011, Antioxidant activity of polysaccharide extracted from abalone gonad, Journal of Dalian Polytechnic University, 30, 177

10.1016/j.carbpol.2012.07.047

10.1038/35025203

10.1016/S0031-9422(00)84542-2

10.1016/0003-2697(79)90738-3

10.1016/j.lfs.2005.11.005

10.1016/j.peptides.2009.11.007

10.1016/j.etap.2014.01.004

SAC, 2016, National food safety standard determination of protein in foods

Su Y. C., 2010, Extraction of polysaccharides from abalone viscera and its antioxidant activity, Jilin Agricultural, 10, 170

10.1016/j.ijbiomac.2013.03.048

Wang T., 2007, Study on the hypoglycemic and hypolipidemic effect of Laminaria japonica polysaccharide, Acta Nutrimenta Sinica, 29, 99

Wang Z. Q., 2015, Extraction of polysaccharides from Haliotis discus hanai Ino gonad and immunomodulating activity in vivo of polysaccharides, Chinese Journal of Marine Drugs, 34, 34

10.1016/j.fct.2009.05.041

Wu H. L., 2007, Introduction of dyslipidemia and its harm to health, China Practical Medicine, 2, 67

10.1016/j.carbpol.2013.02.037

10.1007/s10811-007-9282-4

10.1016/j.fbp.2011.02.002

10.1016/j.jbiotec.2008.07.1376

Thông tin
Thông tin xuất bản

Food Science and Nutrition

Tập 8 Số 5

2524-2534

Thông tin tác giả