Hypertension Is a Major Contributor to 20-Hydroxyeicosatetraenoic Acid–Mediated Kidney Injury in Diabetic Nephropathy

Journal of the American Society of Nephrology : JASN - Tập 26 Số 3 - Trang 597-610 - 2015
Mahesha Gangadhariah1, James M. Luther2, Víctor García3, Paisit Paueksakon4, Ming Zhi Zhang1, Simon W. Hayward5, Harold D. Love5, John R. Falck6, Vijaya L. Manthati6, John D. Imig7, Michal L. Schwartzman3, Roy Zent8, Jorge H. Capdevila1, Ambra Pozzi8
1Divisions of *Nephrology and
2Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, Tennessee;
3Department of Pharmacology, New York Medical College, Valhalla, New York.
4Departments of §Pathology Immunology and Microbiology and
5‖Urologic Surgery; Vanderbilt University, Nashville, Tennessee;
6Division of Chemistry, University of Texas Southwestern Medical Center, Dallas, Texas;
7Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin; and.
8††Department of Medicine, Veterans Affairs Hospitals, Nashville, Tennessee

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Whiting, 2011, IDF diabetes atlas: Global estimates of the prevalence of diabetes for 2011 and 2030., Diabetes Res Clin Pract, 94, 311, 10.1016/j.diabres.2011.10.029

Craig, 2009, Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to type 1 diabetes., Diabet Med, 26, 1090, 10.1111/j.1464-5491.2009.02846.x

Sandholm, 2012, New susceptibility loci associated with kidney disease in type 1 diabetes., PLoS Genet, 8, e1002921, 10.1371/journal.pgen.1002921

Sun, 2013, Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy., Biochem Biophys Res Commun, 433, 359, 10.1016/j.bbrc.2013.02.120

Pirkle, 2013, Hypertension and chronic kidney disease: Controversies in pathogenesis and treatment., Minerva Urol Nefrol, 65, 37

Volpe, 2013, The dual role of free fatty acid signaling in inflammation and therapeutics., Recent Pat Endocr Metab Immune Drug Discov, 7, 189, 10.2174/18715303113139990041

Powell, 1998, Metabolism of arachidonic acid to 20-hydroxy-5,8,11, 14-eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11., J Pharmacol Exp Ther, 285, 1327

Capdevila, 2002, Microsomal cytochrome P450 and eicosanoid metabolism., Cell Mol Life Sci, 59, 780, 10.1007/s00018-002-8466-y

Lasker, 2000, Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11., J Biol Chem, 275, 4118, 10.1074/jbc.275.6.4118

Wu, 2014, 20-HETE and blood pressure regulation: Clinical implications., Cardiol Rev, 22, 1, 10.1097/CRD.0b013e3182961659

Ward, 2004, Urinary 20-hydroxyeicosatetraenoic acid is associated with endothelial dysfunction in humans., Circulation, 110, 438, 10.1161/01.CIR.0000136808.72912.D9

Nowicki, 1997, 20-Hydroxyeicosa-tetraenoic acid (20 HETE) activates protein kinase C. Role in regulation of rat renal Na+,K+-ATPase., J Clin Invest, 99, 1224, 10.1172/JCI119279

Yu, 2007, Effects of 20-HETE on Na+ transport and Na+ -K+ -ATPase activity in the thick ascending loop of Henle., Am J Physiol Regul Integr Comp Physiol, 292, R2400, 10.1152/ajpregu.00791.2006

Ominato, 1996, Regulation of Na-K-ATPase activity in the proximal tubule: Role of the protein kinase C pathway and of eicosanoids., J Membr Biol, 152, 235, 10.1007/s002329900101

Eid, 2009, Mechanisms of podocyte injury in diabetes: Role of cytochrome P450 and NADPH oxidases., Diabetes, 58, 1201, 10.2337/db08-1536

Muller, 2007, Mouse Cyp4a isoforms: Enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation., Biochem J, 403, 109, 10.1042/BJ20061328

Holla, 2001, Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension., Proc Natl Acad Sci U S A, 98, 5211, 10.1073/pnas.081627898

Wu, 2013, Androgen-sensitive hypertension associates with upregulated vascular CYP4A12-20-HETE synthase., J Am Soc Nephrol, 24, 1288, 10.1681/ASN.2012070714

Van Buren, 2013, The pathogenesis and management of hypertension in diabetic kidney disease., Med Clin North Am, 97, 31, 10.1016/j.mcna.2012.10.003

Weil, 2012, Podocyte detachment and reduced glomerular capillary endothelial fenestration promote kidney disease in type 2 diabetic nephropathy., Kidney Int, 82, 1010, 10.1038/ki.2012.234

Sodhi, 2010, CYP4A2-induced hypertension is 20-hydroxyeicosatetraenoic acid- and angiotensin II-dependent., Hypertension, 56, 871, 10.1161/HYPERTENSIONAHA.110.154559

Cheng, 2012, Induction of angiotensin-converting enzyme and activation of the renin-angiotensin system contribute to 20-hydroxyeicosatetraenoic acid-mediated endothelial dysfunction., Arterioscler Thromb Vasc Biol, 32, 1917, 10.1161/ATVBAHA.112.248344

Park, 2009, Chronic blockade of 20-HETE synthesis reduces polycystic kidney disease in an orthologous rat model of ARPKD., Am J Physiol Renal Physiol, 296, F575, 10.1152/ajprenal.90705.2008

Nilakantan, 2008, 20-HETE-mediated cytotoxicity and apoptosis in ischemic kidney epithelial cells., Am J Physiol Renal Physiol, 294, F562, 10.1152/ajprenal.00387.2007

Eid, 2013, 20-HETE and EETs in diabetic nephropathy: A novel mechanistic pathway., PLoS ONE, 8, e70029, 10.1371/journal.pone.0070029

Ma, 1993, 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries., Circ Res, 72, 126, 10.1161/01.RES.72.1.126

Quigley, 2009, Increased renal proximal convoluted tubule transport contributes to hypertension in Cyp4a14 knockout mice., Nephron, Physiol, 113, 23, 10.1159/000235774

Fidelis, 2010, Renal function and vasomotor activity in mice lacking the Cyp4a14 gene., Exp Biol Med (Maywood, 235, 1365, 10.1258/ebm.2010.009233

Ogawa, 2013, Identification of the stages of diabetic nephropathy at which angiotensin II receptor blockers most effectively suppress albuminuria., Am J Hypertens, 26, 1064, 10.1093/ajh/hpt085

Argyrakopoulou, 2013, Antihypertensive treatment in diabetic patients. Review of current data., Maturitas, 75, 142, 10.1016/j.maturitas.2013.03.012

Capdevila, 1990, Cytochrome P-450 arachidonate oxygenase., Methods Enzymol, 187, 385, 10.1016/0076-6879(90)87045-5

Ito, 1995, Regulation of blood pressure by the type 1A angiotensin II receptor gene., Proc Natl Acad Sci U S A, 92, 3521, 10.1073/pnas.92.8.3521

Chen, 2004, Lack of integrin alpha1beta1 leads to severe glomerulosclerosis after glomerular injury., Am J Pathol, 165, 617, 10.1016/S0002-9440(10)63326-3

Mundel, 1997, Induction of differentiation in cultured rat and human podocytes., J Am Soc Nephrol, 8, 697, 10.1681/ASN.V85697

Prakash, 1992, 20-Hydroxyeicosatetraenoic acid is excreted as a glucuronide conjugate in human urine., Biochem Biophys Res Commun, 185, 728, 10.1016/0006-291X(92)91686-K