Hydrocortisone Treatment of Early SIRS in Acute Experimental Pancreatitis

Uhl W, Isenmann R, Curti G, Vogel R, Beger HG, Buchler MW: Influence of etiology on the course and outcome of acute pancreatitis. Pancreas 13:335–343, 1996

British Society of Gastroenterology: United Kingdom guidelines for the management of acute pancreatitis. Gut 42:S1–S13, 1998

Norman JG, Fink GW, Denham W, Yang J, Carter G, Sexton C, Falkner J, Gower WR, Franz MG: Tissue-specific cytokine production during experimental acute pancreatitis. A probable mechanism for distant organ dysfunction. Dig Dis Sci 42:1783–1788, 1997

Norman JG: New approaches to acute pancreatitis: Role of inflammatory mediators. Digestion 60:57–60, 1999

Gloor B, Reber HA: Effects of cytokines, and other inflammatory mediators on human acute pancreatitis. J Intens Care Med 13:305–312, 1998

Osman MO, Jensen SL. Acute pancreatitis: The pathophysiological role of cytokines and integrins. Dig Surg 16:347–362, 1999

Norman J, Franz M, Fink G, Messina J, Fabri P, Gower W, Carey L: Decreased mortality of severe acute pancreatitis after proximal cytokine blockade. Ann Surg 221:625–631, 1995

Gloor B. Todd KE, Lane JS, Lewis MPN, Reber HA: Hepatic Kupffer cell blockade reduces mortality in acute hemorrhagic pancreatitis in mice. J Gastrointest Surg 2:430–435, 1998

Leser HG, Gross V, Scheibenbogen C, Heinisch A, Salm R, Lausen M, Ruckauer K, Andreesen R, Farthmann EH, Scholmerich J: Elevation of serum interleukin-6 concentration precedes acute-phase response and reflects severity in acute pancreatitis. Gastroenterology 101:782–785, 1991

Heath DI, Cruickshank A, Gudgeon M, Jehanli A, Shenkin A, Imrie CW: Role of interleukin-6 in mediating the acute phase protein response and potential as an early means of severity assessment in acute pancreatitis. Gut 34:41–45, 1993

Gross V, Andreesen R, Leser H, Ceska M, Liehl E, Lausen M. Farthmann E, Schoelmerich J: Interleukin-8 and neutrophil activation in acute pancreatitis. Eur J Clin Invest 22:200–203, 1992

Gloor B, Todd KE, Lane JS, Rigberg DA, Reber HA: Mechanism of increased lung injury after acute pancreatitis in IL-10 knockout mice. J Surg Res 80:110–114, 1998

Hughes CB, Gaber LW, Kotb M, Mohey el-Din AB, Pabst M, Gaber AO: Induction of acute pancreatitis in germ-free rats: Evidence of a primary role for tumor necrosis factor-alpha. Surgery 117:201–205, 1995

Buchler M, Malfertheiner P, Schadlich H, Nevalainen TJ, Friess H, Beger HG: Role of phospholipase A2 in human acute pancreatitis. Gastroenterology 97:1521–1526, 1989

Uhl W, Schrag HJ, Schmitter N, Aufenanger J, Nevalainen TJ, Buchler MW: Experimental study of a novel phospholipase A2 inhibitor in acute pancreatitis. Br J Surg 85:618–623, 1998

Uhl W, Schrag HJ, Schmitter N, Nevalainen TJ, Aufenanger J, Wheatley AM, Buchler MW: Pathophysiological role of secre-tory type I and II phospholipase A2 in acute pancreatitis: An experimental study in rats. Gut 40:386–392, 1997

Zhou W, Levine BA, Olson MS: Lipid mediator production in acute and chronic pancreatitis in the rat. J Surg Res 56:37–44, 1994

Manabe T, Steer ML: Protective effects of PGE2 on dietinduced acute pancreatitis in mice. Gastroenterology 78:777–781, 1980

Yamanaka K, Saluja AK, Brown GE, Yamaguchi Y, Hofbauer B, Steer ML: Protective effects of prostaglandin E1 on acute lung injury of caerulein-induced acute pancreatitis in rats. Am J Physiol 272:G23–G30, 1997

Closa D, Rosello-Catafau J, Martrat A, Hotter G, Bulbena O, Fernandez-Cruz L, Gelpi E: Changes of systemic prostacyclin and thromboxane A2 in sodium taurocholate-and ceruleininduced acute pancreatitis in rats. Dig Dis Sci 38:33–38, 1993

Beutler B, Krochin N, Milsark IW, Luedke C, Cerami A: Control of cachectin (tumor necrosis factor) synthesis: mechanisms of endotoxin resistance. Science 232:977–980, 1986

Zanker B, Walz G, Wieder KJ, Strom TB: Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells. Transplantation 49:183–185, 1990

Abe R, Shimosegawa T, Kimura K, Abe T, Kashimura J, Koizumi M, Toyota T: The role of endogenous glucocorticoids in rat experimental models of acute pancreatitis. Gastroenterology 109:933–943, 1995

Kimura K, Shimosegawa T, Sasano H, Abe R, Satoh A, Masamune A, Koizumi M, Nagura H, Toyota T: Endogenous glucocorticoids decrease the acinar cell sensitivity to apoptosis during cerulein pancreatitis in rats. Gastroenterology 114:372–381, 1998

Briegel J, Kellermann W, Forst H, Haller M, Bittl M, Hoffmann GE, Buchler M, Uhl W, Peter K: Low-dose hydrocortisone infusion attenuates the systemic inflammatory response syndrome. Clin Invest 72:782–787, 1994

Aufenanger J, Zimmer W, Kattermann R: Characteristics and clinical application of a radiometric Escherichia coli-based phospholipase A2 assay modified for serum analysis. Clin Chem 39:605–613, 1993

Rongione AJ, Kusske AM, Kwan K, Ashley SW, Reber HA, McFadden DW: Interleukin 10 reduces the severity of acute pancreatitis in rats. Gastroenterology 112:960–967, 1997

Spormann H, Sokolowski A, Letko G: Experimental acute pancreatitis-a quantification of dynamics at enzymic and histomorphologic levels. Pathol Res Pract 185:358–362, 1989

van Ooijen B, Kort WJ, Tinga CJ, Wilson JH: Significance of thromboxane A2 and prostaglandin I2 in acute necrotizing pancreatitis in rats. Dig Dis Sci 35:1078–1084, 1990

van Ooijen B, Ouwendijk RJ, Kort WJ, Zijlstra FJ, Vincent JE, Wilson JH, Westbroek DL: Raised plasma thromboxane B2 levels in experimental acute necrotizing pancreatitis in rats. The effects of flunarizine, dazoxiben, and indomethacin, Scand J Gastroenterol 23:188–92, 1988

Folch E, Prats N, Hotter G, Lopez S, Gelpi E, Rosello-Catafau J, Closa D: P-selectin expression and Kupffer cell activation in rat acute pancreatitis. Dig Dis Sci 45:1535–1544, 2000

de Dios I, San Roman JI, Manso M, Calvo JJ, Lopez MA: Glucocorticoids effects on exocrine pancreatic secretion in caerulein-induced acute pancreatitis in the rat. Arch Int Physiol Biochim 98:361–369, 1990

Abe R, Shimosegawa T, Kikuchi Y, Kimura K, Nagasaki Y, Koizumi M, Toyota T: The role of pituitary-adrenal counterregulation of inflammation in cerulein-induced pancreatitis: A comparison between Fischer and Lewis rats. Pancreas 12:280–285, 1996

Norman J: The role of cytokines in the pathogenesis of acute pancreatitis. Am J Surg 175:76–83, 1998

Osman MO, Jacobsen NO, Kristensen JU, Larsen CG, Jensen SL: Beneficial Effects of Hydrocortisone in a model of experimental acute pancreatitis. Dig Surg 16:214–221, 1999

Tcholakov O, Uhl W, Gloor B, Bischofberger H, Müller CA, Büchler MW: Role of arachidonic acid metabolism and its inhibition by hydrocortisone in experimental acute pancreatitis. Eur Surg Res 31:79–80, 1999

Bone RC, Fisher CJ, Clemmer TP, Slotman GJ, Metz CA, Balk RA: A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med 317:653–658, 1987

Manso MA, Rebollo A, Pescador R, de Dios I. Action of CCK on CDE diet-induced acute pancreatitis in rats treated with hydrocortisone. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 111:257–263, 1995

Gomez G, Townsend CMJ, Green D, Rajaraman S, Uchida T, Thompson JC: Involvement of cholecystokinin receptors in the adverse effect of glucocorticoids on diet-induced necrotizing pancreatitis. Surgery 106:230–238, 1989

Guice KS, Oldham KT, Remick DG, Kunkel SL, Ward PA: Anti-tumor necrosis factor antibody augments edema formation in caerulein-induced acute pancreatitis. J Surg Res 51:495–499, 1991

Lazar G Jr, Varga J, Lazar G, Duda E, Takacs T, Balogh A, Lonovics J: The effects of glucocorticoids and a glucocorticoid antagonist (RU 38486) on experimental acute pancreatitis in rat. Acta Chir Hung 36:190–191, 1997

van den Bosch H, Schalkwijk C, Pfeilschifter J, Märki F: The induction of cellular group II phospholipase A2 by cytokines and its prevention by dexamethasone. Adv Exp Med Biol 318:1–10, 1992

Dinarello CA, Wolff SM: Pathogenesis of fever. In Infectious Diseases. GL Mandell, RG Douglas, JA Bennett (eds). New York, Churchill Livingstone, 1990, pp 462–467