Human defensins
Tóm tắt
Từ khóa
Tài liệu tham khảo
Müller F-MC, Lyman CA, Walsh TJ (1999) Antimicrobial peptides as potential new antifungals. Mycoses 42 [Suppl 2]:77–82
Weinberg A, Krisanaprakornkit S, Dale BA (1998) Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 9:399–414
Schröder J-M (1999) Epithelial antimicrobial peptides: innate local host response elements. Cell Mol Life Sci 56:32–46
De Lucca AJ, Walsh TJ (1999) Antifungal peptides: novel therapeutic compounds against emerging pathogens. Antimicrob Agents Chemother 43:1–11
Lehrer RI, Ganz T (1999) Antimicrobial peptides in mammalian and insect host defence. Curr Opin Immunol 11:23–27
Huttner KM, Bevins CL (1999) Antimicrobial peptides as mediators of epithelial host defense. Pediatr Res 45:785–794
Sparkes RS, Kronenberg M, Heinzmann C, Daher KA, Klisak I, Ganz T, Mohandas T (1989) Assignment of defensin genes to human chromosome 8p23. Genomics 5:240–244
Bevins CL, Jones DE, Dutra A, Schaffzin J, Muenke MM (1996) Human enteric defensin genes: chromosomal map position and a model of possible evolutionary relationships. Genomics 31:95–106
Liu L, Zhao C, Heng HH, Ganz T (1997) The human beta-defensin-1 and alpha-defensins are encoded by adjacent genes: two peptide families with differing disulfide topology share a common ancestry. Genomics 43:316–320
Harder J, Siebert R, Zhang Y, Matthiesen P, Christophers E, Schlegelberger B, Schroder JM (1997) Mapping of the gene encoding human beta-defensin-2 (DEFB2) to chromosome region 8p22-p 23:1. Genomics 46:472–475
Park CH, Valore EV, Waring AJ, Ganz T (2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806–7810
Tang YQ, Yuan J, Osapay G, Osapay K, Tran D, Miller CJ, Ouellette AJ, Selsted ME (1999) A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alpha-defensins. Science 286:489–502
Ganz T (2003) Angiogenin: an antimicrobial ribonuclease. Nat Immunol 5:836–843
Hornef MW, Pütsep K, Karlsson J, Refai E, Andersson M (2004) Increased diversity of intestinal antimicrobial peptides by covalent dimmer formation. Nat Immunol 5:836–843
Zanetti M, Gennaro R, Romeo D (1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett 374:1–5
Kagan BL, Ganz T, Lehrer RI (1994) Defensins: a family of antimicrobial and cytotoxic peptides. Toxicology 87:131–149
Hill CP, Yee J, Selsted ME, Eisenberg D (1991) Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization. Science 251:1481–1485
Bauer F, Schweimer K, Klüver E, Conejo-Garcia JR, Forssmann WG, Rösch P, Adermann K, Sticht H (2001) Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. Protein Sci 10:2470–2479
Zimmermann GR, Legault P, Selsted ME, Pardi A (1995) Solution structure of bovine neutrophil beta-defensin-2: the peptide fold of the beta-defensins is identical to that of the classical defensins. Biochemistry 34:13663–13671
Lehrer RI, Ganz T (1992) Defensins: endogeneous antibiotic peptides from human leukocytes. Ciba Found Symp 171:276–290
Selsted ME, Harwig SS (1989) Determination of the disulfide array in the human defensin HNP-2: a covalently cyclized peptide. J Biol Chem 264:4003–4007
Skalicky JJ, Selsted ME, Pardi A (1994) Structure and dynamics of the neutrophil defensins NP-2, NP-5, and HNP-1: NMR studies of amide hydrogen exchange kinetics. Proteins 20:52–67
Mallow EB, Harris A, Salzman N, Russell JP, DeBerardinis JR, Ruchelli E, Bevins CL (1996) Human enteric defensins: gene structure and developmental expression. J Biol Chem 271:4038–4045
Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI (1985) Defensins: natural peptide antibiotics of human neutrophils. J Clin Invest 76:1427–1435
Wilde CG, Griffith JE, Marra NN, Snable JL, Scott RW (1989) Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family. J Biol Chem 264:11200–11203
Hristova K, Selsted ME, White SH (1996) Interactions of monomeric rabbit neutrophil defensins with bilayers: comparison with dimeric human defensin HNP-2. Biochemistry 35:11888–11894
Soong LB, Ganz T, Ellison A, Caughey GH (1997) Purification and characterization of defensins from cystic fibrosis sputum. Inflamm Res 46:98–102
Ghosh D, Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL (2002) Paneth cell trypsin is the processing enzyme or human defensin-5. Nat Immunol 3:583–590
Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL (2003) Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature 422:522–526
Wilson CL, Ouellette AJ, Satchell DP, Ayabe T, López-Boado YS, Stratman JL, Hultgren SJ, Matrisian LM, Parks WC (1999) Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286:113–117
Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ (2000) Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria. Nat Immunol 1:113–118
Quayle AJ, Porter E, Nussbaum AA, Wang YM, Brabec C, Yip K-P, Mok SC (1998) Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. Am J Pathol 152:1247–1258
Svinarich DM, Gomez R, Romero R (1997) Detection of human defensins in the placenta. Am J Reprod Immunol 38:252–255
Lehrer RI, Lichtenstein AK, Ganz T (1993) Defensins: antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 11:105–128
Daher KA, Selsted ME, Lehrer RI (1986) Direct inactivation of viruses by human granulocyte defensins. J Virol 60:1068–1074
Lehrer RI, Ganz T, Szklarek D, Selsted ME (1988) Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations. J Clin Invest 81:1829–1835
Couto MA, Liu L, Lehrer RI, Ganz T (1994) Inhibition of intracellular Histoplasma capsulatum replication by murine macrophages that produce human defensin. Infect Immun 62:2375–2378
Porter EM, Van Dam E, Valore EV, Ganz T (1997) Broad-spectrum antimicrobial activity of human intestinal defensin 5. Infect Immun 65:2396–2601
Tang YQ, Selsted ME (1993) Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils. J Biol Chem 268:6649–6653
Diamond G, Zasloff M, Eck H, Brasseur M, Maloy WL, Bevins CL (1991) Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. Proc Natl Acad Sci USA 88:3952–3956
Schonwetter BS, Stolzenberg ED, Zasloff MA (1995) Epithelial antibiotics induced at sites of inflammation. Science 267:1645–1648
Mathews M, Jia HP, Guthmiller JM, Losh G, Graham S, Johnson GK, Tack BF, McCray PB Jr (1999) Production of β-defensin antimicrobial peptides by the oral mucosa and salivary glands. Infect Immun 67:2740–2745
Bensch KW, Raida M, Mägert HJ, Schulz-Knappe P, Forssmann WG (1995) hBD-1: a novel β-defensin from human plasma. FEBS Lett 368:331–335
Fulton C, Anderson GM, Zasloff M, Bull R, Quinn AG (1997) Expression of natural peptide antibiotics in human skin. Lancet 350:1750–1751
Zhao C, Wang I, Lehrer RI (1996) Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells. FEBS Lett 396:319–322
McCray PB Jr, Bentley L (1997) Human airway epithelia express a beta-defensin. Am J Respir Cell Mol Biol 16:343–349
Krisanaprakornkit S, Weinberg A, Perez CN, Dale BA (1998) Expression of the peptide antibiotic human β-defensin 1 in cultured gingival epithelial cells and gingival tissue. Infect Immun 66:4222–4228
Valore EV, Park CH, Quayle AJ, Wiles KR, McCray PB Jr, Ganz T (1998) Human β-defensin-1: an antimicrobial peptide of urogenital tissues. J Clin Invest 101:1633–1642
Goldman MJ, Anderson GM, Stolzenberg ED, Kart UP, Zasloff M, Wilson JM (1997) Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553–580
Knowles MR, Robinson JM, Wood RE, Pue CA, Mentz WM, Wager GC, Gatzy JT, Boucher RC (1997) Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease control subjects. J Clin Invest 100:2588–2595
Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW, Boucher RC (1998) Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95:1005–1015
Harder J, Bartels J, Christophers E, Schröder J-M (1997) A peptide antibiotic from human skin. Nature 387:861
Bals R, Wang X, Wu Z, Freeman T, Bafna V, Zasloff M, Wilson JM (1998) Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest 102:874–880
Hiratsuka T, Nakazato M, Date Y, Ashitani J, Minematsu T, Chino N, Matsukura S (1998) Identification of human beta-defensin-2 in respiratory tract and plasma and its increase in bacterial pneumonia. Biochem Biophys Res Commun 249:943–947
Chadebech P, Goidin D, Jacquet C, Viac J, Schmitt D, Staquet MJ (2003) Use of human reconstructed epidermis to analyze the regulation of beta-defensin hBD-1, hBD-2, and hBD-3 expression in response to LPS. Cell Biol Toxicol 19:313–324
Donnarumma G, Paoletti I, Buommino E, Orlando M, Tufano MA, Baroni A (2004) Malassezia furfur induces the expression of β-defensin-2 in human keratinocytes in a protein kinase C-dependent manner. Arch Dermatol Res 295:474–481
Singh PK, Jia HP, Wiles K, Hesselberth J, Liu L, Conway B-AD, Greenberg EP, Valore EV, Welsh MJ, Ganz T, Tack BF, McCray PB Jr (1998) Production of β-defensins by human airway epithelia. Proc Natl Acad Sci USA 95:14961–14966
Chung WO, Hansen SR, Rao D, Dale BA (2004) Protease-activated receptor signaling increases epithelial antimicrobial peptide expression. J Immunol 173:5165–5170
Harder J, Bartels J, Christophers E, Schröder JM (2001) Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotic. J Biol Chem 276:5707–5713
Garcia JR, Jaumann F, Schulz S, Krause A, Rodriguez-Jimenez J, Forssmann U, Adermann K, Klüver E, Vogelmeier C, Becker D, Hedrich R, Forssmann W-G, Bals R (2001) Identification of a novel, multifunctional β-defensin (hBD-3) with specific antimicrobial activity: its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res 306:257–264
Diamond G, Kaiser V, Rhodes J, Russell JP, Bevins CL (2000) Transcriptional regulation of β-defensin gene expression in tracheal epithelial cells. Infect Immun 68:113–119
Jia HP, Schutte BC, Schudy A, Linzmeier R, Guthmiller JM, Johnson GK, Tack BF, Mitros JP, Rosenthal A, Ganz T, McCray PB Jr (2001) Discovery of new human beta-defensins using a genomics-based approach. Gene 263:211–218
Garcia JR, Krause A, Schulz S, Rodriguez-Jimenez F-J, Klüver E, Adermann K, Forssmann U, Frimpong-Boateng A, Bals R, Forssmann W-G (2001) Human β-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J 15:1819–1821
Peschel A, Otto M, Jack RW, Kalbacher H, Jung G, Gotz F (1999) Inactivation of the dlt operon in Staphylococcus aureus confers sensitivity to defensins, protegrins, and other antimicrobial peptides. J Biol Chem 274:8405–8410
Lehrer RI, Barton A, Daher K, Harwig SS, Ganz T, Selsted ME (1989) Interaction of human defensins with Escherichia coli: mechanism of bactericidal activity. J Clin Invest 84:553–561
Kagan BL, Selsted ME, Ganz T, Lehrer RI (1990) Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes. Proc Natl Acad Sci USA 87:210–214
Fujii G, Selsted ME, Eisenberg D (1993) Defensins promote fusion and lysis of negatively charged membranes. Protein Sci 2:1301–1312
Wimley WC, Selsted ME, White SH (1994) Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores. Protein Sci 3:1362–1373
Lohner K, Latal A, Lehrer RI, Ganz T (1997) Differential scanning microcalorimetry indicates that human defensin, HNP-2, interacts specifically with biomembrane mimetic systems. Biochemistry 36:1525–1531
Cociancich S, Ghazi A, Hetru C, Hoffmann JA, Letellier L (1993) Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J Biol Chem 268:19239–19245
Raj PA, Antonyraj KJ, Karuna S, Karan T (2000) Large-scale synthesis and functional elements for the antimicrobial activity of defensins. Biochem J 347:633–641
Oren Z, Shai Y (1997) Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study. Biochemistry 36:1826–1835
Hancock REW, Diamond G (2000) The role of cationic antimicrobial peptides in innate host defenses. Trends Microbiol 8:402–410
Shimoda M, Ohki K, Shimamoto Y, Kohashi O (1995) Morphology of defensin-treated Staphylococcus aureus. Infect Immun 63:2886–2891
Oren Z, Shai Y (1996) A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus. Eur J Biochem 237:303–310
Chan SC, Yau WL, Wang W, Smith DK, Sheu FS, Chen HM (1998) Microscopic observations of the different morphological changes caused by anti-bacterial peptides on Klebsiella pneumoniae and HL-60 leukemia cells. J Pept Sci 4:413–425
Matsuzaki K, Shioyama T, Okamura E, Umemura J, Takenaka T, Takaishi Y, Fujita T, Miyajima K (1991) A comparative study on interactions of alpha-aminoisobutyric acid containing antibiotic peptides, trichopolyn I and hypelcin A with phosphatidylcholine bilayers. Biochim Biophys Acta 1070:419–428
Sieprawska-Lupa M, Mydel P, Krawczyk K, Wojcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J (2004) Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases. Antimicrob Agents Chemother 48:4673–4679
Campos MA, Vargas MA, Regueiro V, Llompart CM, Alberti S, Bengoechea JA (2004) Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides. Infect Immun 72:7107–7114
Fedtke I, Gotz F, Peschel A (2004) Bacterial evasion of innate host defenses—the Staphylococcus aureus lesson. Int J Med Microbiol 294:189–194
Yang D, Chertov O, Oppenheim JJ (2001) Participation of mammalian defensins and cathelicidins in anti-microbial immunity: receptors and activities of human defensins and cathelicidin (LL-37). J Leukoc Biol 69:691–697
Yang D, Chertov O, Oppenheim JJ (2001) The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity. Cell Mol Life Sci 58:978–989
Biragyn A, Surenhu M, Yang D, Ruffini PA, Haines BA, Klyushnenkova E, Oppenheim JJ, Kwak LW (2001) Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. J Immunol 167:6644–6653
Hancock REW (2000) Cationic antimicrobial peptides: towards clinical applications. Expert Opin Investig Drugs 9:1723–1729
Hancock REW (1999) Host defense (cationic) peptides: what is their future clinical potential? Drugs 57:469–473
De Lucca AJ, Bland JM, Grimm C, Jacks TJ, Cary JW, Jaynes JM, Cleveland TE, Walsh TJ (1998) Fungicidal properties, sterol binding, and proteolytic resistance of the synthetic peptide D4E1. Can J Microbiol 44:514–520
Maloy WL, Kari UP (1995) Structure-activity studies on magainins and other host defense peptides. Biopolymers 37:105–122
Cirioni O, Giacometti A, Ghiselli R, Mocchegiani F, Fineo A, Orlando F, Del Prete MS, Rocci M, Saba V, Scalise G (2002) Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model. Antimicrob Agents Chemother 46:101–104
Chen J, Falla TJ, Liu H, Hurst MA, Fujii CA, Mosca DA, Embree JR, Loury DJ, Radel PA, Cheng Chang C, Gu L, Fiddes JC (2000) Development of protegrins for the treatment and prevention of oral mucositis: structure-activity relationships of synthetic protegrin analogues. Biopolymers 55:88–98
Osusky M, Zhou G, Osuska L, Hancock RE, Kay WW, Misra S (2000) Transgenic plants expressing cationic peptide chimeras exhibit broad-spectrum resistance to phytopathogens. Nat Biotechnol 18:1162–1166
Hancock REW, Lehrer R (1998) Cationic peptides: a new source of antibiotics. Trends Biotechnol 16:82–88
Simon C, Stille W (2000) Antibiotika-Therapie in Klinik und Praxis. Schattauer, Stuttgart, pp 205–212