Human atherosclerotic plaques express DC‐SIGN, a novel protein found on dendritic cells and macrophages

Journal of Pathology - Tập 198 Số 4 - Trang 511-516 - 2002
Elizabeth J. Soilleux1,2, LS Morris2, John Trowsdale1, Nicholas Coleman2, JJ Boyle3,2
1Department of Immunology, University of Cambridge, Cambridge, UK
2Medical Research Council Cancer Centre Unit, Hutchinson/MRC Research Centre, Cambridge, UK
3Department of Histopathology, The Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK.

Tóm tắt

AbstractThe association of autoimmune phenomena with atherosclerosis suggests that plaques may contain specialized antigen‐presenting cells, dendritic cells (DCs). DC‐SIGN is a C‐type lectin expressed by DCs. This study assessed whether human atherosclerotic plaques expressed DC‐SIGN and several other macrophage/DC markers. Plaques from human coronary and carotid arteries and aorta contained DC‐SIGN‐immunoreactive cells. Double‐labelling showed co‐expression of DC‐SIGN and macrophage/DC lineage markers CD14, CD68, HLA‐DR, and S100. There was no immunoreactivity for the DC activation markers CD83 or CMRF‐44. Since DC‐SIGN mediates adhesion to T‐lymphocytes and endocytosis, its expression in atherosclerotic plaques may have functional implications. Activated DCs migrate quickly from areas of inflammation to regional lymph nodes, possibly explaining the paucity of activated DCs in atherosclerotic plaques. In conclusion, this study has shown that DC‐SIGN is expressed in atherosclerosis. Copyright © 2002 John Wiley & Sons, Ltd.

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Journal of Pathology

Tập 198 Số 4

511-516

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