Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases

EMBO Journal - Tập 17 Số 21 - Trang 6124-6134 - 1998
Marja Jäättelä1, Dorte Wissing1, Klaus Kokholm1, Tuula Kallunki1, Mikala Egeblad1
1Apoptosis Laboratory, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK-2100, Copenhagen, Denmark

Tóm tắt

Từ khóa


Tài liệu tham khảo

Beyaer, 1997, Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor, J Biol Chem, 272, 11694, 10.1074/jbc.272.18.11694

Boise, 1993, Bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death, Cell, 744, 597, 10.1016/0092-8674(93)90508-N

Bossy-Wetzel, 1998, Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization, EMBO J, 17, 37, 10.1093/emboj/17.1.37

Cardone, 1997, The regulation of anoikis: MEKK-1 activation requires cleavage by caspases, Cell, 90, 315, 10.1016/S0092-8674(00)80339-6

Ciocca, 1993, Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications, J Natl Cancer Inst, 85, 570, 10.1093/jnci/85.7.570

Deveraux, 1997, X-linked IAP is a direct inhibitor of cell-death proteases, Nature, 388, 300, 10.1038/40901

Ferrarini, 1993, Unusual expression and localization of heat-shock proteins in human tumor cells, Int J Cancer, 51, 613, 10.1002/ijc.2910510418

Ghayur, 1996, Proteolytic activation of protein kinase C δ by ICE/CED 3-like protease induces characteristics of apoptosis, J Exp Med, 184, 2399, 10.1084/jem.184.6.2399

Graves, 1998, Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1, EMBO J, 17, 2224, 10.1093/emboj/17.8.2224

Hibi, 1993, Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain, Genes Dev, 7, 2135, 10.1101/gad.7.11.2135

Jäättelä, 1993, Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2, J Immunol, 151, 4286, 10.4049/jimmunol.151.8.4286

Jäättelä, 1995, Overexpression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells, Int J Cancer, 60, 689, 10.1002/ijc.2910600520

Jäättelä, 1993, Heat shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection, J Exp Med, 177, 231, 10.1084/jem.177.1.231

Jäättelä, 1989, Heat shock protects WEHI-164 target cells from the cytolysis by tumor necrosis factors α and β, Eur J Immunol, 19, 1413, 10.1002/eji.1830190810

Jäättelä, 1992, Major heat shock protein hsp70 protects tumor cells from tumor necrosis factor cytotoxicity, EMBO J, 11, 3507, 10.1002/j.1460-2075.1992.tb05433.x

Jäättelä, 1995, Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells, Oncogene, 10, 2297

Jonston, 1988, Competitive inhibition of hsp70 gene expression causes thermosensitivity, Science, 242, 1551, 10.1126/science.3201244

Kallunki, 1994, JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation, Genes Dev, 8, 2996, 10.1101/gad.8.24.2996

Karlseder, 1996, Hsp70 overexpression mediates the escape of a doxorubicin induced G2 cell cycle arrest, Biochem Biophys Res Commun, 220, 153, 10.1006/bbrc.1996.0373

Kaur, 1995, Differential expression of 70-kDa heat shock protein in human oral tumorigenesis, Int J Cancer, 63, 774, 10.1002/ijc.2910630604

Kerr, 1972, Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics, Br J Cancer, 26, 239, 10.1038/bjc.1972.33

Kerr, 1994, Apoptosis. Its significance in cancer and cancer therapy, Cancer, 73, 2013, 10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J

Kluck, 1997, The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis, Science, 275, 1132, 10.1126/science.275.5303.1132

Lazebnik, 1994, Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE, Nature, 371, 346, 10.1038/371346a0

Lee, 1997, Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis, Proc Natl Acad Sci USA, 94, 13642, 10.1073/pnas.94.25.13642

Li, 1982, Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts, Proc Natl Acad Sci USA, 79, 3218, 10.1073/pnas.79.10.3218

Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1

Liu, 1996, Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9

Liu, 1997, DFF, a heteromeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis, Cell, 89, 175, 10.1016/S0092-8674(00)80197-X

Liu, 1996, Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kB activation prevents cell death, Cell, 87, 565, 10.1016/S0092-8674(00)81375-6

Milarski, 1986, Expression of human HSP70 during synthetic phase of the cell cycle, Proc Natl Acad Sci USA, 83, 9517, 10.1073/pnas.83.24.9517

Mivechi, 1990, Use of polymerase chain reaction to detect the expression of the Mr 70,000 heat shock genes in control or heat shock leukemic cells as correlated to their heat response, Cancer Res, 50, 2877

Mosser, 1997, Role of human heat shock protein hsp70 in protection against stress-induced apoptosis, Mol Cell Biol, 17, 5317, 10.1128/MCB.17.9.5317

Nagata, 1997, Apoptosis by death factor, Cell, 88, 355, 10.1016/S0092-8674(00)81874-7

Natoli, 1997, Activation of SAPK/JNK by TNF receptor through a noncytotoxic TRAF2-dependent pathway, Science, 275, 200, 10.1126/science.275.5297.200

Polla, 1996, Mitochondria are selective targets for the protective effects of heat shock against oxidative injury, Proc Natl Acad Sci USA, 93, 6458, 10.1073/pnas.93.13.6458

Riabolow, 1988, Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70, Science, 242, 433, 10.1126/science.3175665

Rothe, 1995, The TNFR2-TRAF signaling complex contains two novel proteins related to baculovirus inhibitor of apoptosis proteins, Cell, 83, 1243, 10.1016/0092-8674(95)90149-3

Saksela, 1993, Negative regulation of immunoglobulin kappa light-chain gene transcription by a short sequence homologous to the murine B1 repetitive element, Mol Cell Biol, 13, 3698, 10.1128/MCB.13.6.3698

Seo, 1996, T cell lymphoma in transgenic mice expressing the human hsp70 gene, Biochem Biophys Res Commun, 218, 582, 10.1006/bbrc.1996.0103

Shimizu, 1996, Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act at a different step during inhibition of death induced by respiratory chain inhibitors, Oncogene, 13, 21

Simon, 1995, Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release, J Clin Invest, 95, 926, 10.1172/JCI117800

Susin, 1997, The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis, J Exp Med, 186, 25, 10.1084/jem.186.1.25

Tewari, 1995, Fas- and tumor necrosis factor-induced apoptosis is inhibited by poxvirus crmA gene product, J Biol Chem, 270, 3255, 10.1074/jbc.270.7.3255

Tewari, 1995, Yama/CPP32β, a mammalian homolog of CED-3, is a crmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase, Cell, 81, 801, 10.1016/0092-8674(95)90541-3

Vaux, 1988, Bcl-2 gene promotes haemopoetic cell survival and cooperates with c-myc to immortalize pre-B cells, Nature, 335, 440, 10.1038/335440a0

Verheij, 1996, Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis, Nature, 380, 75, 10.1038/380075a0

White, 1996, Life, death and the pursuit of apoptosis, Genes Dev, 10, 1, 10.1101/gad.10.1.1

Wissing, 1997, Involvement of caspase-dependent activation of cytosolic phospholipase A2 in tumor necrosis factor-induced apoptosis, Proc Natl Acad Sci USA, 94, 5073, 10.1073/pnas.94.10.5073

Wissing, 1998, TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20, Free Radical Biol Med, 25, 57, 10.1016/S0891-5849(98)00043-4

Woo, 1998, Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes, Genes Dev, 12, 806, 10.1101/gad.12.6.806

Xia, 1995, Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science, 270, 1326, 10.1126/science.270.5240.1326

Yang, 1997, Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria is blocked, Science, 275, 1129, 10.1126/science.275.5303.1129

Zamzami, 1995, Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death, J Exp Med, 182, 367, 10.1084/jem.182.2.367