How receptor diffusion influences gradient sensing

Journal of the Royal Society Interface - Tập 12 Số 102 - Trang 20141097 - 2015
Huyen Nguyen1, Peter Dayan2, Geoffrey J. Goodhill1,3
1Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia
2Gatsby Computational Neuroscience Unit, UCL, London, UK
3School of Mathematics and Physics, The University of Queensland, St Lucia, Queensland, Australia

Tóm tắt

Chemotaxis, or directed motion in chemical gradients, is critical for various biological processes. Many eukaryotic cells perform spatial sensing, i.e. they detect gradients by comparing spatial differences in binding occupancy of chemosensory receptors across their membrane. In many theoretical models of spatial sensing, it is assumed, for the sake of simplicity, that the receptors concerned do not move. However, in reality, receptors undergo diverse modes of diffusion, and can traverse considerable distances in the time it takes such cells to turn in an external gradient. This sets a physical limit on the accuracy of spatial sensing, which we explore using a model in which receptors diffuse freely over the membrane. We find that the Fisher information carried in binding and unbinding events decreases monotonically with the diffusion constant of the receptors.

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Tài liệu tham khảo

10.1016/j.tins.2007.11.008

10.1038/nrm2679

10.1016/0952-7915(94)90042-6

10.1073/pnas.0703530104

10.1242/jcs.018077

10.1016/S0006-3495(77)85544-6

10.1073/pnas.0504321102

10.1529/biophysj.106.100263

10.1073/pnas.0900715106

10.1103/PhysRevLett.105.048104

10.1016/j.jtbi.2014.06.022

10.1146/annurev.biophys.34.040204.144637

10.1002/biot.201100360

10.1016/j.bbrc.2006.01.126

10.1016/j.jneumeth.2011.10.019

10.1242/jcs.129916

10.1007/978-1-60761-198-1_28

10.1016/j.immuni.2009.12.005

10.1016/j.physd.2009.09.009

10.1103/PhysRevE.86.060901

10.1073/pnas.0911178107

10.1103/PhysRevLett.103.158101

10.1103/PhysRevLett.104.248101

10.2967/jnumed.113.121814

Ljunquist-Hoddelius P, 1991, Lateral diffusion of PDGF beta-receptors in human fibroblasts, Biosci. Rep., 9, 63

10.1074/jbc.274.42.30169

10.1007/978-90-481-9864-1_1

10.1038/nsmb.2135

10.1529/biophysj.104.056192

10.1126/scisignal.2000980

10.1073/pnas.1406608111

10.1126/science.1063951

10.1242/jcs.063990

10.1073/pnas.0702536104

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Journal of the Royal Society Interface

Tập 12 Số 102

20141097

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