How Free Fatty Acids Inhibit Glucose Utilization in Human Skeletal Muscle

Physiology - Tập 19 Số 3 - Trang 92-96 - 2004
Michael Roden1
1First Medical Department, Hanusch Hospital, A-1140 Vienna, Austria

Tóm tắt

Rat muscle studies suggest competition between free fatty acids (FFA) and glucose for oxidation, resulting in glucose-6-phosphate accumulation. However, FFA decrease glucose-6-phosphate in human skeletal muscle, indicating direct inhibition of glucose transport/phosphorylation. This mechanism could redirect glucose from muscle to brain during fasting and explain the insulin resistance associated with high-lipid diets and obesity.

Từ khóa


Tài liệu tham khảo

10.2337/diab.6.6.475

10.1172/JCI117252

10.1172/JCI115399

10.1152/ajpendo.1998.275.4.E665

10.1172/JCI5001

10.2337/diabetes.51.7.2005

10.1042/cs0820219

10.2337/diabetes.49.5.677

Krebs M, Krssak M, Nowotny P, Weghuber D, Gruber S, Mlynarik V, Bischof M, Stingl H, Furnsinn C, Waldhausl W, and Roden M. Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 86: 2153–2160, 2001.

10.1210/jcem.87.1.8187

10.1210/rp.56.1.265

10.1002/(SICI)1099-0895(199812)14:4<263::AID-DMR233>3.0.CO;2-C

Randle PJ, Garland PB, Hales CN, and Newsholme EA. The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet: 785–789, 1963.

10.1097/00075197-200107000-00003

10.2337/diabetes.48.2.358

10.1172/JCI118742

10.1146/annurev.med.50.1.277

10.2337/diabetes.49.5.701

10.1152/ajpendo.1993.264.4.E599

10.1172/JCI10583

10.2337/diabetes.49.11.1761

10.1172/JCI115432

10.1038/sj.ijo.0802005

Thông tin
Thông tin xuất bản

Physiology

Tập 19 Số 3

92-96

Thông tin tác giả