Honey as a Potential Natural Antioxidant Medicine: An Insight into Its Molecular Mechanisms of Action

Oxidative Medicine and Cellular Longevity - Tập 2018 Số 1 - 2018
Sarfraz Ahmed1,2, Siti Amrah Sulaiman3, Atif Amin Baig4, Muhammad Ibrahim1, Sana Liaqat1, Saira Fatima1, Sadia Jabeen1, Nighat Shamim1, Nor Hayati Othman2
1Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan
2Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150 Kelantan, Malaysia
3Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia
4Faculty of Medicine, Universiti Sultan Zainal Abidin, Darul Iman, Kuala Terengganu, 20400 Terengganu, Malaysia

Tóm tắt

Honey clasps several medicinal and health effects as a natural food supplement. It has been established as a potential therapeutic antioxidant agent for various biodiverse ailments. Data report that it exhibits strong wound healing, antibacterial, anti‐inflammatory, antifungal, antiviral, and antidiabetic effects. It also retains immunomodulatory, estrogenic regulatory, antimutagenic, anticancer, and numerous other vigor effects. Data also show that honey, as a conventional therapy, might be a novel antioxidant to abate many of the diseases directly or indirectly associated with oxidative stress. In this review, these wholesome effects have been thoroughly reviewed to underscore the mode of action of honey exploring various possible mechanisms. Evidence‐based research intends that honey acts through a modulatory road of multiple signaling pathways and molecular targets. This road contemplates through various pathways such as induction of caspases in apoptosis; stimulation of TNF‐α, IL‐1β, IFN‐γ, IFNGR1, and p53; inhibition of cell proliferation and cell cycle arrest; inhibition of lipoprotein oxidation, IL‐1, IL‐10, COX‐2, and LOXs; and modulation of other diverse targets. The review highlights the research done as well as the apertures to be investigated. The literature suggests that honey administered alone or as adjuvant therapy might be a potential natural antioxidant medicinal agent warranting further experimental and clinical research.

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Oxidative Medicine and Cellular Longevity

Tập 2018 Số 1

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