Honey Extracts Exhibit Cytoprotective Properties against UVB-Induced Photodamage in Human Experimental Skin Models

Farley, 2012, The anatomy and physiology of the locomotor system, Nurs. Stand., 27, 35, 10.7748/ns.27.9.35.s52

Kanitakis, 2002, Anatomy, histology and immunohistochemistry of normal human skin, Eur. J. Dermatol., 12, 390

Gallo, 2017, Human Skin Is the Largest Epithelial Surface for Interaction with Microbes, J. Investig. Dermatol., 137, 1213, 10.1016/j.jid.2016.11.045

Matsumura, 2004, Toxic effects of ultraviolet radiation on the skin, Toxicol. Appl. Pharmacol., 195, 298, 10.1016/j.taap.2003.08.019

Diffey, 2002, Sources and measurement of ultraviolet radiation, Methods, 28, 4, 10.1016/S1046-2023(02)00204-9

Gilchrest, 1996, A review of skin ageing and its medical therapy, Br. J. Dermatol., 135, 867, 10.1046/j.1365-2133.1996.d01-1088.x

Narayanan, 2010, Ultraviolet radiation and skin cancer, Int. J. Dermatol., 49, 978, 10.1111/j.1365-4632.2010.04474.x

McCallion, 1993, Dry and photo–aged skin:and manifestations management, J. Clin. Pharm. Ther., 18, 15, 10.1111/j.1365-2710.1993.tb00562.x

Chen, 2014, UV signaling pathways within the skin, J. Investig. Dermatol., 134, 2080, 10.1038/jid.2014.161

Park, J.M., and Kang, T.H. (2016). Transcriptional and posttranslational regulation of nucleotide excision repair: The guardian of the genome against ultraviolet radiation. Int. J. Mol. Sci., 17.

Xuan, 2017, The effect of dehydroglyasperin C on UVB-mediated MMPs expression in human HaCaT cells, Pharmacol. Rep., 69, 1224, 10.1016/j.pharep.2017.05.012

Verma, 2007, Matrix metalloproteinases (MMPs): Chemical-biological functions and (Q)SARs, Bioorganic Med. Chem., 15, 2223, 10.1016/j.bmc.2007.01.011

Rinnerthaler, 2015, Oxidative stress in aging human skin, Biomolecules, 5, 545, 10.3390/biom5020545

Sharma, 2012, Reactive Oxygen Species, Oxidative Damage, and Antioxidative Defense Mechanism in Plants under Stressful Conditions, J. Bot., 2012, 1, 10.1155/2012/217037

Siddiqui, 2017, Application of analytical methods in authentication and adulteration of honey, Food Chem., 217, 687, 10.1016/j.foodchem.2016.09.001

Premratanachai, 2014, Review of the anticancer activities of bee products, Asian Pac. J. Trop. Biomed., 4, 337, 10.12980/APJTB.4.2014C1262

Pichichero, 2009, Characterization of the phenolic and flavonoid fractions and antioxidant power of Italian honeys of different botanical origin, J. Sci. Food Agric., 89, 609, 10.1002/jsfa.3484

Rahman, 2014, Neurological effects of honey: Current and future prospects, Evid. Based Complement. Altern. Med., 2014, 958721, 10.1155/2014/958721

Cooper, 2016, Honey for wound care in the 21st century, J. Wound Care, 25, 544, 10.12968/jowc.2016.25.9.544

Molan, 2004, Clinical usage of honey as a wound dressing: An update, J. Wound Care, 13, 353, 10.12968/jowc.2004.13.9.26708

Israili, 2014, Antimicrobial properties of honey, Am. J. Ther., 21, 304, 10.1097/MJT.0b013e318293b09b

Erejuwa, 2014, Effects of honey and its mechanisms of action on the development and progression of cancer, Molecules, 19, 2497, 10.3390/molecules19022497

Erejuwa, 2012, Honey: A novel antioxidant, Molecules, 17, 4400, 10.3390/molecules17044400

2008, Functional properties of honey, propolis, and royal jelly, J. Food Sci., 73, R117

Mandal, 2011, Honey: Its medicinal property and antibacterial activity, Asian Pac. J. Trop. Biomed., 1, 154, 10.1016/S2221-1691(11)60016-6

Kasala, 2015, Chemopreventive and therapeutic potential of chrysin in cancer: Mechanistic perspectives, Toxicol. Lett., 233, 214, 10.1016/j.toxlet.2015.01.008

Ahmed, 2013, Honey as a potential natural anticancer agent: A review of its mechanisms, Evid. Based Complement. Altern. Med., 2013, 829070, 10.1155/2013/829070

Mandal, M., and Jaganathan, S.K. (2009). Antiproliferative effects of honey and of its polyphenols: A review. J. Biomed. Biotechnol., 2009.

Gauche, 2016, Honey: Chemical composition, stability and authenticity, Food Chem., 196, 309, 10.1016/j.foodchem.2015.09.051

Saikaly, 2017, Honey and Wound Healing: An Update, Am. J. Clin. Dermatol., 18, 237, 10.1007/s40257-016-0247-8

Ahmed, 2018, Honey as a potential natural antioxidant medicine: An insight into its molecular mechanisms of action, Oxid. Med. Cell Longev., 2018, 8367846, 10.1155/2018/8367846

Bucekova, M., Jardekova, L., Juricova, V., Bugarova, V., Di Marco, G., Gismondi, A., Leonardi, D., Farkasovska, J., Godocikova, J., and Laho, M. (2019). Antibacterial Activity of Different Blossom Honeys: New Findings. Molecules, 24.

Wu, 2011, Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage, J. Agric. Food Chem., 59, 8391, 10.1021/jf200931t

Leduc, 2012, UV, stress and aging, Dermatoendocrinol, 4, 236, 10.4161/derm.23652

Jarrett, 2013, UV radiation and the skin, Int. J. Mol. Sci., 14, 12222, 10.3390/ijms140612222

Ohe, 2004, Harmonized methods of melissopalynology, Apidologie, 35, 18, 10.1051/apido:2004050

Ouchemoukh, 2017, Characterisation of phenolic compounds in Algerian honeys by RP-HPLC coupled to electrospray time-of-flight mass spectrometry, LWT Food Sci. Technol., 85, 460, 10.1016/j.lwt.2016.11.084

Hoff, 1977, A method for determination of tannis in foods by means of immobilized protein, J. Food Sci., 42, 1566, 10.1111/j.1365-2621.1977.tb08427.x

Miliauskas, 2004, Screening of radical scavenging activity of some medicinal and aromatic plant extracts, Food Chem., 85, 231, 10.1016/j.foodchem.2003.05.007

Karapetsas, A., Voulgaridou, G.P., Konialis, M., Tsochantaridis, I., Kynigopoulos, S., Lambropoulou, M., Stavropoulou, M.I., Stathopoulou, K., Aligiannis, N., and Bozidis, P. (2019). Propolis extracts inhibit UV-induced photodamage in human experimental in vitro skin models. Antioxidants, 8.

Chatatikun, 2013, Phytochemical screening and free radical scavenging activities of orange baby carrot and carrot (Daucus carota Linn.) root crude extracts, J. Chem. Pharm. Res., 5, 97

Re, 1999, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Radic. Biol. Med., 26, 1231, 10.1016/S0891-5849(98)00315-3

Pellegrini, 1998, Screening of dietary carotenoids and carotenoid-rich fruit extracts for antioxidant activities applying 2,2′-azinobis(3-ethylenebenzothiazoline-6- sulfonic acid radical cation decolorization assay, Methods Enzymol., 299, 379, 10.1016/S0076-6879(99)99037-7

Lee, 1998, Evaluation of the antioxidant potential of natural products, Comb. Chem. High Throughput Screen., 1, 35, 10.2174/138620730101220118151526

Olive, 2006, The comet assay: A method to measure DNA damage in individual cells, Nat. Protoc., 1, 23, 10.1038/nprot.2006.5

Afaq, 2009, Protective effect of pomegranate-derived products on UVB-mediated damage in human reconstituted skin, Exp. Dermatol., 18, 553, 10.1111/j.1600-0625.2008.00829.x

Yan, 2014, Ultraviolet radiation, aging and the skin: Prevention of damage by topical cAMP manipulation, Molecules, 19, 6202, 10.3390/molecules19056202

Awad, 2018, Photoaging and skin cancer: Is the inflammasome the missing link?, Mech. Ageing Dev., 172, 131, 10.1016/j.mad.2018.03.003

Han, 2018, Black rice (Oryza sativa L.) extract modulates ultraviolet-induced expression of matrix metalloproteinases and procollagen in a skin cell model, Int. J. Mol. Med., 41, 3073

Barbosa, 2014, CAM use in dermatology. Is there a potential role for honey, green tea, and vitamin C?, Complement. Ther. Clin. Pract., 20, 11, 10.1016/j.ctcp.2013.11.003

Mendoza, 2012, Quality parameters and antioxidant and antibacterial properties of some Mexican honeys, J. Food Sci., 77, C121

Chua, 2013, Antioxidant activity of three honey samples in relation with their biochemical components, J. Anal. Methods Chem., 2013, 313798, 10.1155/2013/313798

Islam, 2017, Physicochemical and Antioxidant Properties of Honeys from the Sundarbans Mangrove Forest of Bangladesh, Prev. Nutr. Food Sci., 22, 335, 10.3746/pnf.2017.22.4.335

Zalibera, 2008, Antioxidant and radical-scavenging activities of Slovak honeys—An electron paramagnetic resonance study, Food Chem., 110, 512, 10.1016/j.foodchem.2008.02.015

Habib, 2014, Bioactive components, antioxidant and DNA damage inhibitory activities of honeys from arid regions, Food Chem., 153, 28, 10.1016/j.foodchem.2013.12.044

Kolayli, 2016, A comparative study of the antihyaluronidase, antiurease, antioxidant, antimicrobial and physicochemical properties of different unifloral degrees of chestnut (Castanea sativa Mill.) honeys, J. Enzym. Inhib. Med. Chem., 31, 96, 10.1080/14756366.2016.1209494

Jerković, I., Marijanović, Z., Zekić, M., and Tuberoso, C.I.G. (2017). First Report on Rare Unifloral Honey of Endemic Moltkia petraea (Tratt.) Griseb. from Croatia: Detailed Chemical Screening and Antioxidant Capacity. Chem. Biodivers., 14.

Jubri, 2013, Manuka honey protects middle-aged rats from oxidative damage, Clinics, 68, 1446, 10.6061/clinics/2013(11)11

Alzahrani, 2012, Evaluation of the antioxidant activity of three varieties of honey from different botanical and geographical origins, Glob. J. Health Sci., 4, 191, 10.5539/gjhs.v4n6p191

Baek, 2015, Total phenolic contents and antioxidant activities of Korean domestic honey from different floral sources, Food Sci. Biotechnol., 24, 1453, 10.1007/s10068-015-0187-8

Battino, M., Giampieri, F., Cianciosi, D., Ansary, J., Chen, X., Zhang, D., Gil, E., and Forbes-Hernández, T. (2020). The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation. Phytomedicine.

Cianciosi, D., Forbes-Hernández, T.Y., Afrin, S., Gasparrini, M., Reboredo-Rodriguez, P., Manna, P.P., Zhang, J., Lamas, L.B., Flórez, S.M., and Agudo Toyos, P.A. (2020). Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules, 23.

Giampieri, 2016, Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing, J. Funct. Foods, 25, 38, 10.1016/j.jff.2016.05.008

Ahmad, 2013, Gelam honey protects against gamma-irradiation damage to antioxidant enzymes in human diploid fibroblasts, Molecules, 18, 2200, 10.3390/molecules18022200

Mothana, 2013, Attenuation of CCl4-induced oxidative stress and hepatonephrotoxicity by Saudi sidr honey in rats, Evid. Based Complement. Altern. Med., 2013, 569037

Cheng, 2015, Buckwheat honey attenuates carbon tetrachloride-induced liver and DNA damage in mice, Evid. Based Complement. Altern. Med., 2015, 987385, 10.1155/2015/987385

Almasaudi, 2016, Antioxidant, anti-inflammatory, and antiulcer potential of Manuka honey against gastric ulcer in rats, Oxid. Med. Cell Longev., 2016, 3643824, 10.1155/2016/3643824

Almasaudi, 2017, Manuka honey exerts antioxidant and anti-inflammatory activities that promote healing of acetic acid-induced gastric ulcer in rats, Evid. Based Complement. Altern. Med., 2017, 5413917, 10.1155/2017/5413917

Cheng, 2017, The Protective Effect of Whole Honey and Phenolic Extract on Oxidative DNA Damage in Mice Lymphocytes Using Comet Assay, Plant. Foods Hum. Nutr., 72, 388, 10.1007/s11130-017-0634-1

Alleva, 2016, Organic honey supplementation reverses pesticide-induced genotoxicity by modulating DNA damage response, Mol. Nutr. Food Res., 60, 2243, 10.1002/mnfr.201600005

Afroz, 2016, DNA Damage Inhibition Properties of Sundarban Honey and its Phenolic Composition, J. Food Biochem., 40, 436, 10.1111/jfbc.12240

Sahhugi, 2014, Protective effects of gelam honey against oxidative damage in young and aged rats, Oxid. Med. Cell Longev., 2014, 673628, 10.1155/2014/673628

Ahmad, 2012, Tualang honey protects keratinocytes from ultraviolet radiation-induced inflammation and DNA damage, Photochem. Photobiol., 88, 1198, 10.1111/j.1751-1097.2012.01100.x

Haza, 2013, Spanish honeys protect against food mutagen-induced DNA damage, J. Sci. Food Agric., 93, 2995, 10.1002/jsfa.6129

Dekanski, 2018, Manuka honey attenuates oxidative damage induced by H2O2 in human whole blood in vitro, Food Chem. Toxicol., 119, 61, 10.1016/j.fct.2018.05.034

Pittayapruek, P., Meephansan, J., Prapapan, O., Komine, M., and Ohtsuki, M. (2016). Role of matrix metalloproteinases in Photoaging and photocarcinogenesis. Int. J. Mol. Sci., 17.

Majtan, 2013, Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: A new action of honey in wound healing, Arch. Dermatol. Res., 305, 619, 10.1007/s00403-013-1385-y

Moskwa, J., Borawska, M.H., Markiewicz-Zukowska, R., Puscion-Jakubik, A., Naliwajko, S.K., Socha, K., and Soroczynska, J. (2014). Polish Natural Bee Honeys Are Anti-Proliferative and Anti-Metastatic Agents in Human Glioblastoma multiforme U87MG Cell Line. PLoS ONE, 9.