Home pesticide exposures and risk of childhood leukemia: Findings from the childhood leukemia international consortium

International Journal of Cancer - Tập 137 Số 11 - Trang 2644-2663 - 2015
Helen D. Bailey1, Claire Infante‐Rivard2, Catherine Metayer3, Jacqueline Clavel4,5,6, Tracy Lightfoot7, Peter Kaatsch8, Eve Roman7, Corrado Magnani9, Logan G. Spector10,11, Eleni Petridou12, Elizabeth Milne13, John D. Dockerty14, Lucia Miligi15, Bruce K. Armstrong16,17, Jérémie Rudant4,5,6, Lin Fritschi18, Jill Simpson7, Luoping Zhang3, Roberto Rondelli19, Margarita Baka20, Laurent Orsi4,5, Maria Moschovi21, Alice Y. Kang3, Joachim Schüz1
1International Agency for Research on Cancer (IARC), Section of Environment and Radiation, Lyon, France
2Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Canada
3University of California, Berkeley, School of Public Health, Berkeley, CA
4Inserm U1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Epidemiology of childhood and adolescent cancers team (EPICEA), Villejuif, France
5Paris‐Descartes University UMRS‐1153, Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS) Paris France
6RNCE – National Registry of Childhood Cancers Villejuif France
7Department of Health Sciences, University of York, York, United Kingdom
8German Childhood Cancer Registry (GCCR), The Institute for Medical Biostatistics, Epidemiology and Informatics, University Medical Centre, Johannes Gutenberg University Mainz, Mainz, Germany
9Dipartimento di Medicina Traslazionale, Universita` del Piemonte Orientale, AOU Maggiore della Carita` e CPO, Novara, Italy
10Department of Pediatrics and Masonic Cancer Center, University of Minnesota, Minneapolis, MN
11Division of Epidemiology Clinical Research, University of Minnesota, Minneapolis, MN
12Department of Hygiene, Epidemiology and Medical Statistics, National and Kapodistrian University of Athens Medical School, Athens, Greece
13Telethon Kids Institute, University of Western Australia, Perth, Australia
14Dean’s Department and Department of Preventive and Social Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
15ISPO-Cancer Prevention and Research Institute, Occupational and Environmental Epidemiology Unit, Florence, Italy
16Sax Institute, Ultimo, NSW, Australia
17Sydney School of Public Health, University of Sydney, NSW, Australia
18Curtin University School of Public Health, Perth, Australia
19Department of Paediatric Haematology‐Oncology Lalla Seràgnoli, Policlinico Sant'Orsola Malpighi Bologna Italy
20Department of Pediatric Hematology‐Oncology “Pan.&Agl. Kyriakou” Children's Hospital Athens Greece
21Hematology-Oncology Unit, First Department of Pediatrics, Athens University Medical School, “Aghia Sophia” General Children’s Hospital, Athens, Greece

Tóm tắt

Some previous studies have suggested that home pesticide exposure before birth and during a child's early years may increase the risk of childhood leukemia. To further investigate this, we pooled individual level data from 12 case–control studies in the Childhood Leukemia International Consortium. Exposure data were harmonized into compatible formats. Pooled analyses were undertaken using multivariable unconditional logistic regression. The odds ratio (ORs) for acute lymphoblastic leukemia (ALL) associated with any pesticide exposure shortly before conception, during pregnancy and after birth were 1.39 (95% confidence interval [CI]: 1.25, 1.55) (using 2,785 cases and 3,635 controls), 1.43 (95% CI: 1.32, 1.54) (5,055 cases and 7,370 controls) and 1.36 (95% CI: 1.23, 1.51) (4,162 cases and 5,179 controls), respectively. Corresponding ORs for risk of acute myeloid leukemia (AML) were 1.49 (95% CI: 1.02, 2.16) (173 cases and 1,789 controls), 1.55 (95% CI: 1.21, 1.99) (344 cases and 4,666 controls) and 1.08 (95% CI: 0.76, 1.53) (198 cases and 2,655 controls), respectively. There was little difference by type of pesticide used. The relative similarity in ORs between leukemia types, time periods and pesticide types may be explained by similar exposure patterns and effects across the time periods in ALL and AML, participants' exposure to multiple pesticides, or recall bias. Although some recall bias is likely, until a better study design can be found to investigate the associations between home pesticide use and childhood leukemia in an equally large sample, it would appear prudent to limit the use of home pesticides before and during pregnancy, and during childhood.

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International Journal of Cancer

Tập 137 Số 11

2644-2663

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