Sự biến đổi Histone: Từ bản đồ toàn bộ bộ gen đến những hiểu biết chức năng

Genome Biology - Tập 6 - Trang 1-6 - 2005
Fred van Leeuwen1, Bas van Steensel1
1Netherlands Cancer Institute, Amsterdam, The Netherlands

Tóm tắt

Một số lượng lớn các biến đổi histone đã được liên kết với việc điều chỉnh biểu hiện gen. Tất cả những biến đổi này có tiềm năng hình thành một mã quy định kết hợp phức tạp. Các phương pháp lập bản đồ toàn bộ genome cung cấp những cơ hội mới để giải mã mã này, nhưng chúng có thể gặp phải những thiên lệch hệ thống. Sự tích hợp các tập dữ liệu và các công nghệ cải tiến sẽ mở ra con đường phía trước.

Từ khóa

#biến đổi histone #biểu hiện gen #mã quy định #bản đồ toàn bộ bộ gen #công nghệ sinh học

Tài liệu tham khảo

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