Histological diagnosis of interstitial lung diseases by cryo‐transbronchial biopsy

Respirology - Tập 19 Số 5 - Trang 683-688 - 2014
Oren Fruchter1,2, Ludmila Fridel3, Bayya Abed El Raouf1, Nader Abdel‐Rahman1, Dror Rosengarten1, Mordechai R. Kramer1,2
1Institute of Pulmonary Rabin Medical Center Petah Tiqwa Israel
2The Sackler School of Medicine; Tel-Aviv University; Tel Aviv Israel
3Department of Pathology, Rabin Medical Center, Petah Tiqwa, Israel

Tóm tắt

AbstractBackground and objectiveThe gold standard for the histological diagnosis of interstitial lung diseases (ILD) is an open lung biopsy (OLB). Tissue samples obtained by forceps transbronchial lung biopsies (TBB) are usually too small. We aim to evaluate the efficacy and safety of cryo‐TBB for the diagnosis of ILD and to explore its role as substitute for OLB.MethodsSeventy‐five patients (mean age 56.2 years) with clinical and radiological features suggestive of ILD underwent cryo‐TBB under moderate sedation. The diagnostic contribution on the work‐up of suspected ILD was assessed.ResultsNo major complications occurred during cryo‐TBB procedures. The mean cross‐sectional area of the biopsy specimen obtained was 9 mm2 with an average of 70% alveolated tissue. The most common pathological diagnoses were idiopathic nonspecific interstitial pneumonitis (n = 22), cryptogenic organizing pneumonia (n = 11) and usual interstitial pneumonitis (n = 7). There were three patients of pulmonary Langerhans cell histiocytosis and one patient of pulmonary lymphangioleiomyomatosis. A definite and probable clinicopathological consensus diagnosis was possible in 70% and 28% of patients, respectively. In only 2% of patients' diagnosis could not be established.ConclusionsCryo‐TBB is a safe and effective minimally invasive modality for the diagnosis of ILD. No OLB is needed in the majority of patients.

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Respirology

Tập 19 Số 5

683-688

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