Histocompatibility antigen frequencies in patients with chronic lymphocytic leukaemia: Possible identification of a subgroup with relatively benign disease

Wiley - Tập 33 Số 4 - Trang 391-396 - 1984
D. C. Kilpatrick1, A E Dewar2, G. Stockdill3, Melissa S. Maginnis1, Alexander Jordan1, Graham W. Neill1, K. Gelsthorpe4, P.L. Yap1
1Regional Blood Transfusion Centre, Royal Infirmary, Lauriston Place, Edinburgh, Scotland
2Department of Pathology, University of Edinburgh Scotland
3Department of Clinical and Laboratory Haematology, Western General Hospital, Crewe Road, Edinburgh, Scotland
4Regional Blood Transfusion Centre, Longley Lane, Sheffield, UK

Tóm tắt

A series of 57 patients with chronic lymphocytic leukaemia was typed for HLA‐A, B and DR antigens and compared with a control population of equal size. There was an increased frequency of HLA‐A1 and B8 in the patient group, although it was not statistically significant after allowance for the number of specificities tested. A subgroup of patients lacking both Al and B8 differed from the others in sex ratio, degree of lymphocytosis and incidence of hypogammaglobulinaemia at presentation. This subgroup also had less need for treatment within 6 months of presentation. While these findings must be considered preliminary, it is possible that tissue typing may help to identify patients with a relatively benign form of the disease.—

Từ khóa


Tài liệu tham khảo

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Wiley

Tập 33 Số 4

391-396

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