Histamine and prostaglandin E2 up‐regulate the production of Th2‐attracting chemokines (CCL17 and CCL22) and down‐regulate IFN‐γ‐induced CXCL10 production by immature human dendritic cells

Immunology - Tập 117 Số 4 - Trang 507-516 - 2006
Anne McIlroy1, Gersende Caron2, Simon Blanchard2,1, Isabelle Frémaux2, Dorothée Duluc2, Yves Delneste2, Alain Chevailler1, Pascale Jeannin2,1
1Immunology and Allergology Laboratory
2INSERM U564, Equipe Avenir, University Hospital of Angers, University of Angers, Angers, France

Tóm tắt

SummaryEffector memory T helper 2 (Th2) cells that accumulate in target organs (i.e. skin or bronchial mucosa) have a central role in the pathogenesis of allergic disorders. To date, the factors that selectively trigger local production of Th2‐attracting chemokines remain poorly understood. In mucosa, at the sites of allergen entry, immature dendritic cells (DC) are in close contact with mast cells. Histamine and prostaglandin E2 (PGE2) are two mediators released by allergen‐activated mast cells that favour the polarization of maturing DC into Th2‐polarizing cells. We analysed here the effects of histamine and PGE2 on the prototypic, Th2‐(CCL17, CCL22) versus Th1‐(CXCL10) chemokine production by human DC. We report that histamine and PGE2 dose‐dependently up‐regulate CCL17 and CCL22 by monocyte‐derived immature DC. These effects were potentiated by tumour necrosis factor‐α, still observed in the presence of the Th1‐cytokine interferon‐γ (IFN‐γ) and abolished by the immunomodulatory cytokine interleukin‐10. In addition, histamine and PGE2 down‐regulated IFN‐γ‐induced CXCL10 production by monocyte‐derived DC. These properties of histamine and PGE2 were observed at the transcriptional level and were mediated mainly through H2 receptors for histamine and through EP2 and EP4 receptors for PGE2. Finally, histamine and PGE2 also up‐regulated CCL17 and CCL22 and decreased IFN‐γ‐induced CXCL10 production by purified human myeloid DC. In conclusion, these data show that, in addition to polarizing DC into mature cells that promote naïve T‐cell differentiation into Th2 cells, histamine and PGE2 may act on immature DC to trigger local Th2 cell recruitment through a selective control of Th1/Th2‐attracting chemokine production, thereby contributing to maintain a microenvironment favourable to persistent immunoglobulin E synthesis.

Từ khóa


Tài liệu tham khảo

10.1038/35100503

10.1159/000083893

10.1067/mai.2003.1585

10.1016/j.it.2003.11.001

Gonzalo JA, 1999, Mouse monocyte‐derived chemokine is involved in airway hyperreactivity and lung inflammation, J Immunol, 163, 403, 10.4049/jimmunol.163.1.403

10.1067/mai.2002.126378

10.1093/intimm/dxf044

10.1046/j.1365-2249.2002.01727.x

10.1016/j.jaci.2003.12.007

10.1164/rccm.200405-681OC

10.4049/jimmunol.168.10.5278

10.1056/NEJM200102013440507

10.1016/j.coi.2004.09.004

10.1111/j.1365-2249.1994.tb06148.x

10.4049/jimmunol.166.6.4083

10.4049/jimmunol.166.10.6000

10.1189/jlb.0303116

10.1016/j.jaci.2004.08.041

Katamura K, 1995, Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN‐gamma and IL‐2, but not IL‐4 and IL‐5, J Immunol, 155, 4604, 10.4049/jimmunol.155.10.4604

10.1111/j.1398-9995.2005.00708.x

10.1038/nri1246

Soumelis V, 2002, Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP, Nat Immunol, 3, 605, 10.1038/ni805

10.4049/jimmunol.167.7.3682

10.4049/jimmunol.174.9.5224

10.1007/s004030000159

Kalinski P, 1997, IL‐12‐deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells, J Immunol, 159, 28, 10.4049/jimmunol.159.1.28

10.1002/1521-4141(200103)31:3<812::AID-IMMU812>3.0.CO;2-L

10.1124/jpet.103.062646

10.1084/jem.186.9.1603

10.1182/blood.V97.11.3466

10.1634/stemcells.20-5-448

10.1182/blood-2001-12-0360

10.4049/jimmunol.173.9.5458

10.1182/blood-2001-11-0017

10.1146/annurev.immunol.21.120601.141103

10.1016/S0952-7915(01)00285-0

10.4049/jimmunol.169.12.6673

10.1016/S1043-4666(03)00221-7

Andrew DP, 1998, STCP‐1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL‐4 and IL‐13, J Immunol, 161, 5027, 10.4049/jimmunol.161.9.5027

10.1172/JCI200113930

10.1002/jlb.52.1.27

10.4049/jimmunol.173.10.5952

10.4049/jimmunol.166.3.1650

10.1096/fj.04-1548fje

Hill SJ, 1997, International Union of Pharmacology. XIII. Classification of histamine receptors, Pharmacol Rev, 49, 253

Coleman RA, 1994, International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes, Pharmacol Rev, 46, 205

10.1016/j.jaci.2003.08.012

10.1034/j.1600-065X.2000.17717.x

10.1111/j.1440-1711.2005.01365.x

10.1038/nri746

10.1016/j.coi.2003.09.012

10.1016/S0140-6736(00)03206-2

10.1046/j.1523-1747.2003.12570.x

10.4049/jimmunol.173.8.5275

10.1016/j.coi.2003.09.003

10.1046/j.1365-2222.1999.00006.x-i2

10.1164/rccm.200311-1595OC

10.1016/S0165-2478(01)00184-5

Thông tin
Thông tin xuất bản

Immunology

Tập 117 Số 4

507-516

Thông tin tác giả