Hippocampal brain‐derived neurotrophic factor gene regulation by exercise and the medial septum

Journal of Neuroscience Research - Tập 68 Số 5 - Trang 511-521 - 2002
Nicole C. Berchtold1,2, J. Patrick Kesslak3,2, Carl W. Cotman1,3,2
1Department of Neurobiology and Behavior, University of California, Irvine, California
2Institute for Brain Aging and Dementia, University of California, Irvine, California
3Department of Neurology, University of California, Irvine, Califorinia

Tóm tắt

AbstractBrain‐derived neurotrophic factor (BDNF) enhances synaptic plasticity and neuron function. We have reported that voluntary exercise increases BDNF mRNA levels in the hippocampus; however, mechanisms underlying this regulation have not been defined. We hypothesized that medial septal cholinergic and/or gamma amino butyric acid (GABA)ergic neurons, which provide a major input to the hippocampus, may regulate the baseline gene expression and exercise‐dependent gene upregulation of this neurotrophin. Focal lesions were produced by medial septal infusion of the saporin‐linked immunotoxins 192‐IgG‐saporin or OX7‐saporin. 192‐IgG‐saporin produced a selective and complete loss of medial septal cholinergic neurons with no accompanying GABA loss. Baseline BDNF mRNA was reduced in the hippocampus of sedentary animals, but exercise‐induced gene upregulation was not impaired, despite complete loss of septo‐hippocampal cholinergic afferents. OX7‐saporin produced a graded lesion of the medial septum characterized by predominant GABA neuron loss with less reduction in the number of cholinergic cells. OX7‐saporin lesion reduced baseline hippocampal BDNF mRNA and attenuated exercise‐induced gene upregulation, in a dose‐dependent manner. These results suggest that combined loss of septal GABAergic and cholinergic input to the hippocampus may be important for exercise‐dependent BDNF gene regulation, while cholinergic activity on its own is not sufficient. These results are discussed in relation to their implications for aging and Alzheimer's disease. © 2002 Wiley‐Liss, Inc.

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Journal of Neuroscience Research

Tập 68 Số 5

511-521

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