Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

Conlon, I. & Raff, M. Size control in animal development. Cell 96, 235–244 (1999).

Green, D.R. & Evan, G.I. A matter of life and death. Cancer Cell 1, 19–30 (2002).

Dan, I., Watanabe, N.M. & Kusumi, A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol. 11, 220–230 (2001).

Justice, R.W., Zilian, O., Woods, D.F., Noll, M. & Bryant, P.J. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev. 9, 534–546 (1995).

Xu, T., Wang, W., Zhang, S., Stewart, R.A. & Yu, W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 121, 1053–1063 (1995).

Kango-Singh, M. et al. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129, 5719–5730 (2002).

Tapon, N. et al. salvador promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110, 468–478 (2002).

Newsome, T.P., Asling, B. & Dickson, B.J. Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics. Development 127, 851–860 (2000).

Baker, N.E. Cell proliferation, survival, and death in the Drosophila eye. Semin. Cell Dev. Biol. 12, 499–507 (2001).

Neufeld, T.P., de la Cruz, A.F., Johnston, L.A. & Edgar, B.A. Coordination of growth and cell division in the Drosophila wing. Cell 93, 1183–1193 (1998).

Grether, M.E., Abrams, J.M., Agapite, J., White, K. & Steller, H. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9, 1694–1708 (1995).

White, K., Tahaoglu, E. & Steller, H. Cell killing by the Drosophila gene reaper. Science 271, 805–807 (1996).

Chen, P., Nordstrom, W., Gish, B. & Abrams, J.M. grim, a novel cell death gene in Drosophila. Genes Dev. 10, 1773–1782 (1996).

Christich, A. et al. The damage-responsive Drosophila gene sickle encodes a novel IAP binding protein similar to but distinct from reaper, grim, and hid. Curr. Biol. 12, 137–140 (2002).

Wing, J.P. et al. Drosophila sickle is a novel grim-reaper cell death activator. Curr. Biol. 12, 131–135 (2002).

Srinivasula, S.M. et al. sickle, a novel Drosophila death gene in the reaper/hid/grim region, encodes an IAP-inhibitory protein. Curr. Biol. 12, 125–130 (2002).

Tenev, T., Zachariou, A., Wilson, R., Paul, A. & Meier, P. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. EMBO J. 21, 5118–5129 (2002).

Yoo, S.J. et al. Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms. Nature Cell Biol. 4, 416–424 (2002).

Wang, S.L., Hawkins, C.J., Yoo, S.J., Muller, H.A. & Hay, B.A. The Drosophila caspase inhibitor DIAP1 is essential for cell survival and is negatively regulated by HID. Cell 98, 453–463 (1999).

Lisi, S., Mazzon, I. & White, K. Diverse domains of THREAD/DIAP1 are required to inhibit apoptosis induced by REAPER and HID in Drosophila. Genetics 154, 669–678 (2000).

Goyal, L., McCall, K., Agapite, J., Hartwieg, E. & Steller, H. Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function. EMBO J. 19, 589–597 (2000).

Berger, J. et al. Genetic mapping with SNP markers in Drosophila. Nature Genet. 29, 475–481 (2001).

Cheung, W.L. et al. Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113, 507–517 (2003).

Graves, J.D. et al. Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J. 17, 2224–2234 (1998).

Lee, K.K., Ohyama, T., Yajima, N., Tsubuki, S. & Yonehara, S. MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276, 19276–19285 (2001).

Creasy, C.L., Ambrose, D.M. & Chernoff, J. The Ste20-like protein kinase, Mst1, dimerizes and contains an inhibitory domain. J. Biol. Chem. 271, 21049–21053 (1996).

Kurada, P. & White, K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319–329 (1998).

Bergmann, A., Agapite, J., McCall, K. & Steller, H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331–341 (1998).

Yang, L. & Baker, N.E. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev. Cell 4, 359–369 (2003).

Deng, Y., Pang, A. & Wang, J.H. Regulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis. J. Biol. Chem. 278, 11760–11767 (2003).

Johnston, L.A. & Gallant, P. Control of growth and organ size in Drosophila. BioEssays 24, 54–64 (2002).

Oldham, S. & Hafen, E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 13, 79–85 (2003).

Turenchalk, G.S., St John, M.A., Tao, W. & Xu, T. The role of LATS in cell cycle regulation and tumorigenesis. Biochim. Biophys. Acta 1424, M9–M16 (1999).

Brand, A.H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401–415 (1993).