High surface energy enhances cell response to titanium substrate microstructure

Journal of Biomedical Materials Research - Part A - Tập 74A Số 1 - Trang 49-58 - 2005
Gang Zhao1, Zvi Schwartz1,2, Marco Wieland3, Frank Rupp4, Jürgen Geis‐Gerstorfer4, David L. Cochran5, Barbara D. Boyan1
1Georgia Institute of Technology, Atlanta, Georgia, 30332
2Hebrew University Hadassah, Jerusalem, Israel
3Institut Straumann AG, Waldenburg, Switzerland
4Center of Dentistry, Oral Medicine and Maxillofacial Surgery, University Hospital Tübingen, Tübingen, Germany
5Department of Periodontics, University of Texas Health Science Center at San Antonio, San Antonio, Texas

Tóm tắt

Abstract

Titanium (Ti) is used for implantable devices because of its biocompatible oxide surface layer. TiO2 surfaces that have a complex microtopography increase bone‐to‐implant contact and removal torque forces in vivo and induce osteoblast differentiation in vitro. Studies examining osteoblast response to controlled surface chemistries indicate that hydrophilic surfaces are osteogenic, but TiO2 surfaces produced until now exhibit low surface energy because of adsorbed hydrocarbons and carbonates from the ambient atmosphere or roughness induced hydrophobicity. Novel hydroxylated/hydrated Ti surfaces were used to retain high surface energy of TiO2. Osteoblasts grown on this modified surface exhibited a more differentiated phenotype characterized by increased alkaline phosphatase activity and osteocalcin and generated an osteogenic microenvironment through higher production of PGE2 and TGF‐β1. Moreover, 1α,25(OH)2D3 increased these effects in a manner that was synergistic with high surface energy. This suggests that increased bone formation observed on modified Ti surfaces in vivo is due in part to stimulatory effects of high surface energy on osteoblasts. © 2005 Wiley Periodicals, Inc. J Biomed Mater Res, 2005

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Journal of Biomedical Materials Research - Part A

Tập 74A Số 1

49-58

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