High-dose methotrexate for non-AIDS primary central nervous system lymphoma

Journal of Neurosurgery - Tập 70 Số 2 - Trang 190-194 - 1989
Alberto A. Gabbai1, Fred H. Hochberg, Rita M. Linggood, Rifaat Bashir, Kathleen Holteman
1Department of Neurology, Massachusetts General Hospital, Boston

Tóm tắt

✓ Thirteen patients with primary lymphoma of the central nervous system (CNS) were treated with high-dose intravenous methotrexate (MTX), 3.5 gm/sq m, followed by calcium leucovorin rescue, at 3-week intervals, for three cycles. Eleven patients subsequently received radiation therapy to the whole brain, 30 to 44 Gy. Before radiation therapy, eight patients responded completely and four partially; there was one nonresponder. The median Karnofsky score before high-dose MTX therapy was 60 and increased to 90 after treatment. Five of the eight complete responders reached a Karnofsky rating of 100. The three longest responders (one of whom received MTX only) were without recurrence of their disease at 29+, 32, and 32+ months posttherapy. The median response period is 9+ months. The median survival time from the date of the first MTX treatment is 9+ months, and the three longest survival times are 29+, 32+, and 54+ months. All patients received corticosteroids in either unchanging or diminishing dosages during therapy. It is concluded that primary CNS lymphoma is sensitive to high-dose MTX, which provides a safe and easily administered adjuvant to radiation therapy for this neoplasm.

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Journal of Neurosurgery

Tập 70 Số 2

190-194

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