High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells

Genomics, Proteomics & Bioinformatics - Tập 20 - Trang 657-669 - 2022
Songbiao Zhu1, Wenxi Ding1, Yuling Chen1, Weixuan Wang2, Renhua Xu3, Chongdong Liu4, Xiaohui Liu1, Haiteng Deng1
1MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systematic Biology, School of Life Sciences, Tsinghua University, Beijing 100084, China
2Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
3School of Nursing, Binzhou Medical University, Yantai 264003, China
4Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China

Tài liệu tham khảo

Ericsson, 1966, Comparative light and electron microscopic observations of cytoplasmic matrix in renal carcinomas, Virchows Arch Pathol Anat Physiol Klin Med, 341, 204, 10.1007/BF00961071 Jonasch, 2014, Renal cell carcinoma, BMJ, 349, 10.1136/bmj.g4797 Zarrabi, 2017, New treatment options for metastatic renal cell carcinoma with prior anti-angiogenesis therapy, J Hematol Oncol, 10, 1, 10.1186/s13045-016-0374-y Barata, 2017, Treatment of renal cell carcinoma: current status and future directions, CA Cancer J Clin, 67, 507, 10.3322/caac.21411 Motzer, 1996, Renal cell carcinoma, N Engl J Med, 335, 865, 10.1056/NEJM199609193351207 Cancer Genome Atlas Research Network, 2013, Comprehensive molecular characterization of clear cell renal cell carcinoma, Nature, 499, 43, 10.1038/nature12222 Kaelin, 2008, The von Hippel-Lindau tumour suppressor protein: O2 sensing and cancer, Nat Rev Cancer, 8, 865, 10.1038/nrc2502 Kaelin, 2018, The von Hippel-Lindau tumour suppressor protein, Annu Rev Cancer Biol, 2, 91, 10.1146/annurev-cancerbio-030617-050527 Courtney, 2018, Isotope tracing of human clear cell renal cell carcinomas demonstrates suppressed glucose oxidation in vivo, Cell Metab, 28, 793, 10.1016/j.cmet.2018.07.020 Jo, 2011, Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and trc8, Proc Natl Acad Sci U S A, 108, 20503, 10.1073/pnas.1112831108 Drabkin, 2012, Cholesterol and the development of clear cell renal carcinoma, Curr Opin Pharmacol, 12, 742, 10.1016/j.coph.2012.08.002 Dagher, 2016, Wild-type VHL clear cell renal cell carcinomas are a distinct clinical and histologic entity: a 10-year follow-up, Eur Urol Focus, 3, 284, 10.1016/j.euf.2015.06.001 Kammerer Jacquet, 2017, Independent association of PD-L1 expression with noninactivated VHL clear cell renal cell carcinoma-a finding with therapeutic potential, Int J Cancer, 140, 142, 10.1002/ijc.30429 Batavia, 2019, Clear cell renal cell carcinoma with wild-type von Hippel-Lindau gene: a non-existent or new tumour entity?, Histopathology, 74, 60, 10.1111/his.13749 Guo, 2011, Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma, Nat Genet, 44, 17, 10.1038/ng.1014 Sato, 2013, Integrated molecular analysis of clear cell renal cell carcinoma, Nat Genet, 45, 860, 10.1038/ng.2699 Gerlinger, 2014, Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing, Nat Genet, 46, 225, 10.1038/ng.2891 Cerami, 2012, The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data, Cancer Discov, 2, 401, 10.1158/2159-8290.CD-12-0095 Gao, 2013, Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal, Sci Signal, 6, pl1, 10.1126/scisignal.2004088 Turajlic, 2015, SnapShot: renal cell carcinoma, Cell, 163, 1556, 10.1016/j.cell.2015.11.026 Lee, 2017, RNF20 suppresses tumorigenesis by inhibiting the SREBP1c-PTTG1 axis in kidney cancer, Mol Cell Biol, 37, e00265, 10.1128/MCB.00265-17 Brown, 1997, The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor, Cell, 89, 331, 10.1016/S0092-8674(00)80213-5 Gan, 2006, Technical, experimental and biological variations in isobaric tags for relative and absolute quantitation (iTRAQ), J Proteome Res, 6, 821, 10.1021/pr060474i Subramanian, 2005, Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles, Proc Natl Acad Sci U S A, 102, 15545, 10.1073/pnas.0506580102 Zhang, 2011, Interferon-stimulated gene 15 and the protein ISGylation system, J Interferon Cytokine Res, 31, 119, 10.1089/jir.2010.0110 Bogunovic, 2013, ISG15: leading a double life as a secreted molecule, Exp Mol Med, 45, e18, 10.1038/emm.2013.36 Cheon, 2013, IFNβ-dependent increases in STAT1, STAT2 and IRF9 mediate resistance to viruses and DNA damage, EMBO J, 32, 2751, 10.1038/emboj.2013.203 Szelag, 2013, In silico simulations of STAT1 and STAT3 inhibitors predict SH2 domain cross-binding specificity, Eur J Pharmacol, 720, 38, 10.1016/j.ejphar.2013.10.055 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 5, 646, 10.1016/j.cell.2011.02.013 Hakimi, 2016, An integrated metabolic atlas of clear cell renal cell carcinoma, Cancer Cell, 29, 104, 10.1016/j.ccell.2015.12.004 Tissier, 2005, Mutations of beta-catenin in adrenocortical tumours: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors, Cancer Res, 65, 7622, 10.1158/0008-5472.CAN-05-0593 Zheng, 2016, Comprehensive pan-genomic characterization of adrenocortical carcinoma, Cancer Cell, 5, 723, 10.1016/j.ccell.2016.04.002 Guichard, 2012, Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma, Nat Genet, 44, 694, 10.1038/ng.2256 Bensaad, 2014, Fatty acid uptake and lipid storage induced by HIF-1alpha contribute to cell growth and survival after hypoxia-reoxygenation, Cell Rep, 9, 349, 10.1016/j.celrep.2014.08.056 Qiu, 2015, HIF2alpha-dependent lipid storage promotes endoplasmic reticulum homeostasis in clear cell renal cell carcinoma, Cancer Discov, 5, 652, 10.1158/2159-8290.CD-14-1507 Du, 2017, HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism, Nat Commun, 8, e1769, 10.1038/s41467-017-01965-8 Hu, 2014, Overexpression of CD38 decreases cellular NAD levels and alters the expression of proteins involved in energy metabolism and antioxidant defense, J Proteome Res, 13, 786, 10.1021/pr4010597 Giandomenico, 2003, Coactivator-dependent acetylation stabilizes members of the SREBP Family of transcription factors, Mol Cell Bio, 23, 2587, 10.1128/MCB.23.7.2587-2599.2003 Sanjana, 2014, Improved vectors and genome-wide libraries for CRISPR screening, Nat Methods, 11, 783, 10.1038/nmeth.3047 Ran, 2013, Genome engineering using the CRISPR-Cas9 system, Nat Protoc, 8, 2281, 10.1038/nprot.2013.143 Bligh, 1959, A rapid method of total lipid extraction and purification, Can J Biochem Physiol, 37, 911, 10.1139/y59-099 Tang, 2016, Down-regulation of HSP60 suppresses the proliferation of glioblastoma cells via the ROS/AMPK/mTOR pathway, Sci Rep, 6, e28388, 10.1038/srep28388 Shechter, 2007, Extraction, purification and analysis of histones, Nat Protoc, 2, 1445, 10.1038/nprot.2007.202 Tang, 2017, GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses, Nucleic Acids Res, 45, W98, 10.1093/nar/gkx247 Yu, 2012, ClusterProfiler: an R package for comparing biological themes among gene clusters, OMICS, 16, 284, 10.1089/omi.2011.0118